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• W2025001077 startingPage "3352" @default.
• W2025001077 abstract "Abstract Chronic lymphocytic leukemia (CLL) cells are thought to have diminished cell-cycling capacity, a view challenged by their phenotypic resemblance to activated human B lymphocytes. The present study addresses the cell-cycling status of CLL cells, focusing on those leukemic cells expressing CD38, a molecule involved in signaling and activation that also serves as a prognostic marker in this disease. CD38+ and CD38− members of individual CLL clones were analyzed for coexpression of molecules associated with cellular activation (CD27, CD62L, and CD69), cell-cycle entry (Ki-67), signaling (ZAP-70), and protection from apoptosis (telomerase and Bcl-2). Regardless of the size of the CD38+ fraction within a CLL clone, CD38+ subclones are markedly enriched for expression of Ki-67, ZAP-70, human telomerase reverse transcriptase, and telomerase activity. Although the percentage of cells (approximately 2%) entering the cell cycle as defined by Ki-67 expression is small, the absolute number within a clone can be sizeable and is contained primarily within the CD38+ fraction. Despite these activation/proliferation differences, both CD38+ and CD38− fractions have similar telomere lengths, suggesting that CD38 expression is dynamic and transient. These findings may help explain why high percentages of CD38+ cells within clones are associated with poor clinical outcome." @default.
• W2025001077 created "2016-06-24" @default.
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• W2025001077 creator A5085611202 @default.
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• W2025001077 date "2007-11-01" @default.
• W2025001077 modified "2023-09-27" @default.
• W2025001077 title "CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells" @default.
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• W2025001077 doi "https://doi.org/10.1182/blood-2007-04-083832" @default.
• W2025001077 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2200908" @default.
• W2025001077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17684154" @default.
• W2025001077 hasPublicationYear "2007" @default.
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