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• W2025018429 startingPage "e73294" @default.
• W2025018429 abstract "Systemic hypertension increases cardiac workload and subsequently induces signaling networks in heart that underlie myocyte growth (hypertrophic response) through expansion of sarcomeres with the aim to increase contractility. However, conditions of increased workload can induce both adaptive and maladaptive growth of heart muscle. Previous studies implicate two members of the AP-1 transcription factor family, junD and fra-1, in regulation of heart growth during hypertrophic response. In this study, we investigate the function of the AP-1 transcription factors, c-jun and c-fos, in heart growth. Using pressure overload-induced cardiac hypertrophy in mice and targeted deletion of Jun or Fos in cardiomyocytes, we show that c-jun is required for adaptive cardiac hypertrophy, while c-fos is dispensable in this context. c-jun promotes expression of sarcomere proteins and suppresses expression of extracellular matrix proteins. Capacity of cardiac muscle to contract depends on organization of principal thick and thin filaments, myosin and actin, within the sarcomere. In line with decreased expression of sarcomere-associated proteins, Jun-deficient cardiomyocytes present disarrangement of filaments in sarcomeres and actin cytoskeleton disorganization. Moreover, Jun-deficient hearts subjected to pressure overload display pronounced fibrosis and increased myocyte apoptosis finally resulting in dilated cardiomyopathy. In conclusion, c-jun but not c-fos is required to induce a transcriptional program aimed at adapting heart growth upon increased workload." @default.
• W2025018429 created "2016-06-24" @default.
• W2025018429 creator A5004832527 @default.
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• W2025018429 creator A5077886543 @default.
• W2025018429 creator A5086100763 @default.
• W2025018429 date "2013-09-10" @default.
• W2025018429 modified "2023-10-12" @default.
• W2025018429 title "The AP-1 Transcription Factor c-Jun Prevents Stress-Imposed Maladaptive Remodeling of the Heart" @default.
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• W2025018429 doi "https://doi.org/10.1371/journal.pone.0073294" @default.
• W2025018429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3769267" @default.
• W2025018429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24039904" @default.
• W2025018429 hasPublicationYear "2013" @default.
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