FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025031844> ?p ?o ?g. }

• W2025031844 endingPage "228" @default.
• W2025031844 startingPage "219" @default.
• W2025031844 abstract "Free-energy simulations have been used to estimate the change in the conformational stability of short polyalanine α-helices when one of the alanines is replaced by a proline residue. For substituting proline in the middle of the helix the change in free energy of folding (ΔΔG°) was calculated as 14 kJ/mol (3.4 kcal/mol), in excellent agreement with the one available experimental value. The helix containing proline was found to be strongly kinked; the free energy for reducing the angle of the kink from 40° to 15° was calculated, and found to be small. A tendency to alternate hydrogen bonding schemes was observed in the proline-containing helix. These observations for the oligopeptide agree well with the observation of a range of kink angles (18–35°) and variety of hydrogen bonding schemes, in the rare instances where proline occurs in helices in globular proteins. For substituting proline at the N-terminus of the helix the change in free energy of folding (ΔΔG°) was calculated as −4 kJ/mol in the first helical position (N1) and +6 kJ/mol in the second helical position (N2). The observed frequent occurrence of proline in position N1 in α-helices in proteins therefore has its origin in stability differences of secondary structure. The conclusion reached here that proline may be a better helix former in position N1 than (even) alanine, and thus be a helix initiator may be testable experimentally by measurements of fraction helical conformation of individual residues in oligopeptides of appropriate sequence. The relevance of these results in regards to the frequent occurrence of proline-containing helices in certain membrane proteins is discussed." @default.
• W2025031844 created "2016-06-24" @default.
• W2025031844 creator A5008376231 @default.
• W2025031844 creator A5014143393 @default.
• W2025031844 creator A5045210285 @default.
• W2025031844 date "1991-03-01" @default.
• W2025031844 modified "2023-10-16" @default.
• W2025031844 title "Proline in α-helix: Stability and conformation studied by dynamics simulation" @default.
• W2025031844 cites W1491824558 @default.
• W2025031844 cites W1512775211 @default.
• W2025031844 cites W1522259447 @default.
• W2025031844 cites W1547689858 @default.
• W2025031844 cites W1581111389 @default.
• W2025031844 cites W1968489137 @default.
• W2025031844 cites W1968673134 @default.
• W2025031844 cites W1972501748 @default.
• W2025031844 cites W1981368863 @default.
• W2025031844 cites W1988867706 @default.
• W2025031844 cites W1995938191 @default.
• W2025031844 cites W1999993654 @default.
• W2025031844 cites W2007415752 @default.
• W2025031844 cites W2035266068 @default.
• W2025031844 cites W2036519312 @default.
• W2025031844 cites W2056770911 @default.
• W2025031844 cites W2073962404 @default.
• W2025031844 cites W2075468840 @default.
• W2025031844 cites W2081359387 @default.
• W2025031844 cites W2081431207 @default.
• W2025031844 cites W2087313973 @default.
• W2025031844 cites W2095338319 @default.
• W2025031844 cites W2099047634 @default.
• W2025031844 cites W2106140689 @default.
• W2025031844 cites W2110810808 @default.
• W2025031844 cites W2119773680 @default.
• W2025031844 cites W2317136561 @default.
• W2025031844 doi "https://doi.org/10.1002/prot.340100306" @default.
• W2025031844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1881878" @default.
• W2025031844 hasPublicationYear "1991" @default.
• W2025031844 type Work @default.
• W2025031844 sameAs 2025031844 @default.
• W2025031844 citedByCount "128" @default.
• W2025031844 countsByYear W20250318442012 @default.
• W2025031844 countsByYear W20250318442013 @default.
• W2025031844 countsByYear W20250318442014 @default.
• W2025031844 countsByYear W20250318442015 @default.
• W2025031844 countsByYear W20250318442016 @default.
• W2025031844 countsByYear W20250318442017 @default.
• W2025031844 countsByYear W20250318442018 @default.
• W2025031844 countsByYear W20250318442019 @default.
• W2025031844 countsByYear W20250318442020 @default.
• W2025031844 countsByYear W20250318442021 @default.
• W2025031844 countsByYear W20250318442022 @default.
• W2025031844 countsByYear W20250318442023 @default.
• W2025031844 crossrefType "journal-article" @default.
• W2025031844 hasAuthorship W2025031844A5008376231 @default.
• W2025031844 hasAuthorship W2025031844A5014143393 @default.
• W2025031844 hasAuthorship W2025031844A5045210285 @default.
• W2025031844 hasConcept C105168689 @default.
• W2025031844 hasConcept C109300003 @default.
• W2025031844 hasConcept C112887158 @default.
• W2025031844 hasConcept C119599485 @default.
• W2025031844 hasConcept C127413603 @default.
• W2025031844 hasConcept C13935069 @default.
• W2025031844 hasConcept C147597530 @default.
• W2025031844 hasConcept C178790620 @default.
• W2025031844 hasConcept C185592680 @default.
• W2025031844 hasConcept C18903297 @default.
• W2025031844 hasConcept C204328495 @default.
• W2025031844 hasConcept C2776545253 @default.
• W2025031844 hasConcept C2778530040 @default.
• W2025031844 hasConcept C2779281246 @default.
• W2025031844 hasConcept C2779815552 @default.
• W2025031844 hasConcept C2779856020 @default.
• W2025031844 hasConcept C2779965526 @default.
• W2025031844 hasConcept C32909587 @default.
• W2025031844 hasConcept C47701112 @default.
• W2025031844 hasConcept C515207424 @default.
• W2025031844 hasConcept C55493867 @default.
• W2025031844 hasConcept C59593255 @default.
• W2025031844 hasConcept C62614982 @default.
• W2025031844 hasConcept C71240020 @default.
• W2025031844 hasConcept C8010536 @default.
• W2025031844 hasConcept C86803240 @default.
• W2025031844 hasConceptScore W2025031844C105168689 @default.
• W2025031844 hasConceptScore W2025031844C109300003 @default.
• W2025031844 hasConceptScore W2025031844C112887158 @default.
• W2025031844 hasConceptScore W2025031844C119599485 @default.
• W2025031844 hasConceptScore W2025031844C127413603 @default.
• W2025031844 hasConceptScore W2025031844C13935069 @default.
• W2025031844 hasConceptScore W2025031844C147597530 @default.
• W2025031844 hasConceptScore W2025031844C178790620 @default.
• W2025031844 hasConceptScore W2025031844C185592680 @default.
• W2025031844 hasConceptScore W2025031844C18903297 @default.
• W2025031844 hasConceptScore W2025031844C204328495 @default.
• W2025031844 hasConceptScore W2025031844C2776545253 @default.
• W2025031844 hasConceptScore W2025031844C2778530040 @default.
• W2025031844 hasConceptScore W2025031844C2779281246 @default.
• W2025031844 hasConceptScore W2025031844C2779815552 @default.

• next