FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025040610> ?p ?o ?g. }

• W2025040610 endingPage "806" @default.
• W2025040610 startingPage "799" @default.
• W2025040610 abstract "Abstract— At 25°C the accumulation of [ 3 H] dl ‐2,4‐diaminobutyric acid (DABA) into small rat cortical slices was linear with time and a tissue: medium ratio of 35:1 was attained after 60 min. At 37°C the uptake was no longer linear and the tissue: medium ratio at 60 min was 66:1. Uptake was unaffected by the addition of 10 μ m ‐AOAA and dependent on the presence of Na + in the incubation media. The uptake was shown to have a high affinity component with a K m of 20.7 μ m and a V max of 28.6 nmol/g/min. IC50's for the inhibition of [ 3 H]DABA uptake by dl ‐DABA, l ‐DABA and GABA were 80, 40 and 17 μ m respectively. Two m m β ‐alanine, however, caused less than 13% inhibition of [ 3 H]DABA uptake. Electron microscopic autoradiographs showed the [ 3 H]DABA to be accumulated by 22% of the identifiable nerve terminals and, after 14 days exposure, the density of silver grains over nerve terminals was 36–38 times higher than that over the rest of the electron micrograph. On the other hand, [ 3 H]DABA was not taken up into rat sensory ganglia and light level autoradiography showed the small amount of [ 3 H]DABA accumulated by the ganglia to be evenly distributed throughout the tissue. Both electrical stimulation for 30 s and exposure of the tissue to a medium containing 47 m m ‐K + for 2 min caused a marked increase in the efflux of [ 3 H]DABA from the tissue. Both these effects were abolished by a reduction in Ca 2+ concentration and an increase in the Mg 2+ concentration of the superfusing medium. These results suggest that l ‐DABA acts as a ‘false transmitter’ for the neuronal uptake, storage and release of GABA." @default.
• W2025040610 created "2016-06-24" @default.
• W2025040610 creator A5002501135 @default.
• W2025040610 creator A5027365948 @default.
• W2025040610 creator A5029024060 @default.
• W2025040610 date "1978-04-01" @default.
• W2025040610 modified "2023-10-09" @default.
• W2025040610 title "THE SELECTIVE NEURONAL UPTAKE AND RELEASE OF [³H]DL-2,4-DIAMINOBUTYRIC ACID BY RAT CEREBRAL CORTEX" @default.
• W2025040610 cites W1980088407 @default.
• W2025040610 cites W1985245394 @default.
• W2025040610 cites W1985868885 @default.
• W2025040610 cites W1991097268 @default.
• W2025040610 cites W1991738505 @default.
• W2025040610 cites W1997109993 @default.
• W2025040610 cites W2002865586 @default.
• W2025040610 cites W2015519332 @default.
• W2025040610 cites W2024365402 @default.
• W2025040610 cites W2029501548 @default.
• W2025040610 cites W2030027929 @default.
• W2025040610 cites W2030151757 @default.
• W2025040610 cites W2030578557 @default.
• W2025040610 cites W2031569584 @default.
• W2025040610 cites W2036427763 @default.
• W2025040610 cites W2037862268 @default.
• W2025040610 cites W2039122304 @default.
• W2025040610 cites W2042678909 @default.
• W2025040610 cites W2042765535 @default.
• W2025040610 cites W2054007216 @default.
• W2025040610 cites W2081275438 @default.
• W2025040610 cites W2084477404 @default.
• W2025040610 cites W2114835467 @default.
• W2025040610 doi "https://doi.org/10.1111/j.1471-4159.1978.tb10787.x" @default.
• W2025040610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/650221" @default.
• W2025040610 hasPublicationYear "1978" @default.
• W2025040610 type Work @default.
• W2025040610 sameAs 2025040610 @default.
• W2025040610 citedByCount "35" @default.
• W2025040610 countsByYear W20250406102019 @default.
• W2025040610 crossrefType "journal-article" @default.
• W2025040610 hasAuthorship W2025040610A5002501135 @default.
• W2025040610 hasAuthorship W2025040610A5027365948 @default.
• W2025040610 hasAuthorship W2025040610A5029024060 @default.
• W2025040610 hasConcept C12554922 @default.
• W2025040610 hasConcept C134018914 @default.
• W2025040610 hasConcept C185592680 @default.
• W2025040610 hasConcept C24998067 @default.
• W2025040610 hasConcept C25642318 @default.
• W2025040610 hasConcept C2781041448 @default.
• W2025040610 hasConcept C55493867 @default.
• W2025040610 hasConcept C86803240 @default.
• W2025040610 hasConceptScore W2025040610C12554922 @default.
• W2025040610 hasConceptScore W2025040610C134018914 @default.
• W2025040610 hasConceptScore W2025040610C185592680 @default.
• W2025040610 hasConceptScore W2025040610C24998067 @default.
• W2025040610 hasConceptScore W2025040610C25642318 @default.
• W2025040610 hasConceptScore W2025040610C2781041448 @default.
• W2025040610 hasConceptScore W2025040610C55493867 @default.
• W2025040610 hasConceptScore W2025040610C86803240 @default.
• W2025040610 hasIssue "4" @default.
• W2025040610 hasLocation W20250406101 @default.
• W2025040610 hasLocation W20250406102 @default.
• W2025040610 hasOpenAccess W2025040610 @default.
• W2025040610 hasPrimaryLocation W20250406101 @default.
• W2025040610 hasRelatedWork W2034442213 @default.
• W2025040610 hasRelatedWork W2093190478 @default.
• W2025040610 hasRelatedWork W2136134859 @default.
• W2025040610 hasRelatedWork W2157623399 @default.
• W2025040610 hasRelatedWork W2160875138 @default.
• W2025040610 hasRelatedWork W2357614251 @default.
• W2025040610 hasRelatedWork W2369633239 @default.
• W2025040610 hasRelatedWork W2392367091 @default.
• W2025040610 hasRelatedWork W140302342 @default.
• W2025040610 hasRelatedWork W2037029051 @default.
• W2025040610 hasVolume "30" @default.
• W2025040610 isParatext "false" @default.
• W2025040610 isRetracted "false" @default.
• W2025040610 magId "2025040610" @default.
• W2025040610 workType "article" @default.