Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025049088> ?p ?o ?g. }
- W2025049088 endingPage "28" @default.
- W2025049088 startingPage "23" @default.
- W2025049088 abstract "Major strides have been taken in the regulation of lead intoxication in the general population, but studies using genetic markers of susceptibility to environmental toxicants raise the question of whether genes can make certain individuals more vulnerable to environmental toxins such as lead. At least three polymorphic genes have been identified that potentially can influence the bioaccumulation and toxicokinetics of lead in humans. The first gene to be discussed in this review is the gene coding for delta-aminolevulinic acid dehydratase (ALAD), an enzyme of heme biosynthesis, that exists in two polymorphic forms. The resulting isozymes have been shown to affect the blood and bone lead levels in human populations. The effects of ALAD in lead intoxication have also been studied in laboratory mice that differ in the genetic dose for this enzyme. The second gene reviewed here is the vitamin D receptor (VDR) gene. The VDR is involved in calcium absorption through the gut and into calcium-rich tissues such as bone. Recent findings suggest that VDR polymorphism may influence the accumulation of lead in bone. Finally, the third gene to be discussed here that may influence the absorption of lead is the hemochromatosis gene coding for the HFE protein. The presence of mutations in the HFE gene leads to hemochromatosis in homozygotic individuals. Because of the associations between iron and lead transport, it is possible that polymorphisms in the HFE gene may also influence the absorption of lead, but this has not yet been studied. More studies will be needed to define the role of these genes in lead intoxication." @default.
- W2025049088 created "2016-06-24" @default.
- W2025049088 creator A5059420521 @default.
- W2025049088 creator A5071448016 @default.
- W2025049088 date "2000-03-01" @default.
- W2025049088 modified "2023-10-17" @default.
- W2025049088 title "Genetic susceptibility to lead poisoning." @default.
- W2025049088 cites W111140859 @default.
- W2025049088 cites W139215949 @default.
- W2025049088 cites W142495250 @default.
- W2025049088 cites W1511080365 @default.
- W2025049088 cites W151643130 @default.
- W2025049088 cites W1532646699 @default.
- W2025049088 cites W1547928236 @default.
- W2025049088 cites W1551428274 @default.
- W2025049088 cites W1605391144 @default.
- W2025049088 cites W1896778737 @default.
- W2025049088 cites W1963627938 @default.
- W2025049088 cites W1966411863 @default.
- W2025049088 cites W1968527776 @default.
- W2025049088 cites W1975431948 @default.
- W2025049088 cites W1984193507 @default.
- W2025049088 cites W1985461163 @default.
- W2025049088 cites W1985716134 @default.
- W2025049088 cites W1986860757 @default.
- W2025049088 cites W1986950290 @default.
- W2025049088 cites W1992418427 @default.
- W2025049088 cites W1993764166 @default.
- W2025049088 cites W1998350229 @default.
- W2025049088 cites W2000222427 @default.
- W2025049088 cites W2002605005 @default.
- W2025049088 cites W2003548861 @default.
- W2025049088 cites W2007797116 @default.
- W2025049088 cites W2009180025 @default.
- W2025049088 cites W2017252167 @default.
- W2025049088 cites W2019127918 @default.
- W2025049088 cites W2022977525 @default.
- W2025049088 cites W2031362994 @default.
- W2025049088 cites W2032628299 @default.
- W2025049088 cites W2036923291 @default.
- W2025049088 cites W2037494394 @default.
- W2025049088 cites W2040262552 @default.
- W2025049088 cites W2042632286 @default.
- W2025049088 cites W2045172877 @default.
- W2025049088 cites W2046987213 @default.
- W2025049088 cites W2047124343 @default.
- W2025049088 cites W2050189082 @default.
- W2025049088 cites W2051313316 @default.
- W2025049088 cites W2056187477 @default.
- W2025049088 cites W2057485731 @default.
- W2025049088 cites W2057870444 @default.
- W2025049088 cites W2060054451 @default.
- W2025049088 cites W2060177074 @default.
- W2025049088 cites W206128215 @default.
- W2025049088 cites W2063984548 @default.
- W2025049088 cites W2064961659 @default.
- W2025049088 cites W2065620978 @default.
- W2025049088 cites W2067027353 @default.
- W2025049088 cites W2068224930 @default.
- W2025049088 cites W2070311991 @default.
- W2025049088 cites W2070504970 @default.
- W2025049088 cites W2070541545 @default.
- W2025049088 cites W2071258482 @default.
- W2025049088 cites W2072573469 @default.
- W2025049088 cites W2077342896 @default.
- W2025049088 cites W2078923567 @default.
- W2025049088 cites W2080306972 @default.
- W2025049088 cites W2083076983 @default.
- W2025049088 cites W2086380711 @default.
- W2025049088 cites W2087921054 @default.
- W2025049088 cites W2089161230 @default.
- W2025049088 cites W2089731460 @default.
- W2025049088 cites W2090942619 @default.
- W2025049088 cites W2094366043 @default.
- W2025049088 cites W2094938155 @default.
- W2025049088 cites W2115526102 @default.
- W2025049088 cites W2140816381 @default.
- W2025049088 cites W2142695526 @default.
- W2025049088 cites W2142838364 @default.
- W2025049088 cites W2143476077 @default.
- W2025049088 cites W2150320532 @default.
- W2025049088 cites W2169927309 @default.
- W2025049088 cites W2281708637 @default.
- W2025049088 cites W2313017219 @default.
- W2025049088 cites W2395198130 @default.
- W2025049088 cites W2400708379 @default.
- W2025049088 cites W2403160842 @default.
- W2025049088 cites W2428222999 @default.
- W2025049088 cites W2891215035 @default.
- W2025049088 cites W4233320302 @default.
- W2025049088 cites W4236107211 @default.
- W2025049088 cites W4293546777 @default.
- W2025049088 cites W2092044610 @default.
- W2025049088 doi "https://doi.org/10.1289/ehp.00108s123" @default.
- W2025049088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1637782" @default.
- W2025049088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10698721" @default.
- W2025049088 hasPublicationYear "2000" @default.
- W2025049088 type Work @default.