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- W2025054274 abstract "We investigated the biochemical and growth properties of Schwann cells from the sciatic nerve of Tremble and unaffected mice in culture. Both Trembler and control cultures showed similar growth rates. The specific activity of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) and enzymes involved in lipid metabolism of cerebrosides and sulfatides were studied. UDP-galactose: ceramide galactosyltransferase was significantly decreased in Trembler cultures less than 21 days in vitro. No differences were found in the specific activities of cerebroside sulfotransferase, arylsulfatase A or CNP between Trembler and control cultures. Schwann cells from Trembler and control mice were labeled with [35S]methionine and the protein analyzed by two-dimensional gel electrophoresis. Our study revealed few but consistent differences in the protein pattern synthesized by the Trembler Schwann cells." @default.
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- W2025054274 date "1986-08-01" @default.
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- W2025054274 title "Trembler mouse Schwann cells in culture: Anomalies in the synthesis of lipids and proteins" @default.
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- W2025054274 doi "https://doi.org/10.1016/0006-8993(86)90693-1" @default.
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