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- W2025054983 abstract "Objective The recent introduction of glyceryl trinitrate ointment (GTN) has greatly changed the management of chronic fissure-in-ano. We have investigated the results obtained from this new treatment and the consequent alterations to surgical practice. Patients and methods All patients who presented with chronic fissure-in-ano from March 1997 to March 1998 were treated with GTN ointment and prospectively evaluated until healing or lateral internal sphincterotomy. Long-term follow up was obtained using a telephone questionnaire. Results Forty-five patients were treated with GTN ointment. Twenty-two (49%) were healed initially, but 10/22 (45%) recurred within 36 weeks. Twelve (27%) patients were healed for the duration of this study. Twenty-six (58%) patients complained of headache, of whom five (11%) were forced to abandon treatment. In comparison with the previous year, rates of lateral internal sphincterotomy reduced by 24%. Conclusion GTN is a useful adjunct to the treatment of chronic anal fissure, but sphincterotomy remains the mainstay of treatment." @default.
- W2025054983 created "2016-06-24" @default.
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- W2025054983 date "1999-07-01" @default.
- W2025054983 modified "2023-09-28" @default.
- W2025054983 title "Disappointing results of glyceryl trinitrate ointment in the treatment of chronic fissure-in-ano in a district general hospital" @default.
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- W2025054983 doi "https://doi.org/10.1046/j.1463-1318.1999.00042.x" @default.
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