Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025055898> ?p ?o ?g. }
- W2025055898 endingPage "474" @default.
- W2025055898 startingPage "466" @default.
- W2025055898 abstract "Hsp70s are molecular chaperones involved in the folding and assembly of proteins. They recognize hydrophobic amino acid stretches in their substrate binding groove. However, a detailed understanding of substrate specificity is still missing. Here, we use the endoplasmic reticulum-resident Hsp70 BiP to identify binding sites in a natural client protein. Two sites are mutually recognized and form stable Hsp70–substrate complexes. In silico and in vitro analyses revealed an extended substrate conformation as a crucial factor for interaction and show an unexpected plasticity of the substrate binding groove. The basic binding mechanism is conserved among different Hsp70s." @default.
- W2025055898 created "2016-06-24" @default.
- W2025055898 creator A5034868453 @default.
- W2025055898 creator A5037294253 @default.
- W2025055898 creator A5040631487 @default.
- W2025055898 creator A5066973874 @default.
- W2025055898 creator A5074839515 @default.
- W2025055898 creator A5078384835 @default.
- W2025055898 creator A5079981447 @default.
- W2025055898 creator A5081948104 @default.
- W2025055898 creator A5088881667 @default.
- W2025055898 date "2013-02-01" @default.
- W2025055898 modified "2023-10-03" @default.
- W2025055898 title "Conformational Selection in Substrate Recognition by Hsp70 Chaperones" @default.
- W2025055898 cites W1556340556 @default.
- W2025055898 cites W1579202592 @default.
- W2025055898 cites W1969419906 @default.
- W2025055898 cites W1971172729 @default.
- W2025055898 cites W1971526956 @default.
- W2025055898 cites W1977026532 @default.
- W2025055898 cites W1978014671 @default.
- W2025055898 cites W1978490927 @default.
- W2025055898 cites W1978600513 @default.
- W2025055898 cites W1983137299 @default.
- W2025055898 cites W1984183888 @default.
- W2025055898 cites W1997718936 @default.
- W2025055898 cites W1999719904 @default.
- W2025055898 cites W2002164494 @default.
- W2025055898 cites W2010209610 @default.
- W2025055898 cites W2014294043 @default.
- W2025055898 cites W2015899951 @default.
- W2025055898 cites W2020038750 @default.
- W2025055898 cites W2022358027 @default.
- W2025055898 cites W2028808317 @default.
- W2025055898 cites W2032536046 @default.
- W2025055898 cites W2042232940 @default.
- W2025055898 cites W2043825401 @default.
- W2025055898 cites W2046629597 @default.
- W2025055898 cites W2047476114 @default.
- W2025055898 cites W2051592058 @default.
- W2025055898 cites W2065283382 @default.
- W2025055898 cites W2075569593 @default.
- W2025055898 cites W2075609989 @default.
- W2025055898 cites W2075892193 @default.
- W2025055898 cites W2076945013 @default.
- W2025055898 cites W2088585606 @default.
- W2025055898 cites W2093572741 @default.
- W2025055898 cites W2095789860 @default.
- W2025055898 cites W2108376320 @default.
- W2025055898 cites W2115133023 @default.
- W2025055898 cites W2123018879 @default.
- W2025055898 cites W2123174753 @default.
- W2025055898 cites W2123357563 @default.
- W2025055898 cites W2137060895 @default.
- W2025055898 cites W2145766919 @default.
- W2025055898 cites W2146837416 @default.
- W2025055898 cites W2147564037 @default.
- W2025055898 cites W2150740284 @default.
- W2025055898 cites W2164179462 @default.
- W2025055898 cites W2168009822 @default.
- W2025055898 doi "https://doi.org/10.1016/j.jmb.2012.11.030" @default.
- W2025055898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23207294" @default.
- W2025055898 hasPublicationYear "2013" @default.
- W2025055898 type Work @default.
- W2025055898 sameAs 2025055898 @default.
- W2025055898 citedByCount "37" @default.
- W2025055898 countsByYear W20250558982013 @default.
- W2025055898 countsByYear W20250558982014 @default.
- W2025055898 countsByYear W20250558982015 @default.
- W2025055898 countsByYear W20250558982016 @default.
- W2025055898 countsByYear W20250558982017 @default.
- W2025055898 countsByYear W20250558982018 @default.
- W2025055898 countsByYear W20250558982019 @default.
- W2025055898 countsByYear W20250558982020 @default.
- W2025055898 countsByYear W20250558982021 @default.
- W2025055898 countsByYear W20250558982022 @default.
- W2025055898 countsByYear W20250558982023 @default.
- W2025055898 crossrefType "journal-article" @default.
- W2025055898 hasAuthorship W2025055898A5034868453 @default.
- W2025055898 hasAuthorship W2025055898A5037294253 @default.
- W2025055898 hasAuthorship W2025055898A5040631487 @default.
- W2025055898 hasAuthorship W2025055898A5066973874 @default.
- W2025055898 hasAuthorship W2025055898A5074839515 @default.
- W2025055898 hasAuthorship W2025055898A5078384835 @default.
- W2025055898 hasAuthorship W2025055898A5079981447 @default.
- W2025055898 hasAuthorship W2025055898A5081948104 @default.
- W2025055898 hasAuthorship W2025055898A5088881667 @default.
- W2025055898 hasConcept C104317684 @default.
- W2025055898 hasConcept C107824862 @default.
- W2025055898 hasConcept C119599485 @default.
- W2025055898 hasConcept C12554922 @default.
- W2025055898 hasConcept C127413603 @default.
- W2025055898 hasConcept C142724271 @default.
- W2025055898 hasConcept C158617107 @default.
- W2025055898 hasConcept C181199279 @default.
- W2025055898 hasConcept C185592680 @default.
- W2025055898 hasConcept C18903297 @default.
- W2025055898 hasConcept C204328495 @default.