FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025066818> ?p ?o ?g. }

• W2025066818 endingPage "3288" @default.
• W2025066818 startingPage "3282" @default.
• W2025066818 abstract "By means of liquid chromatography-tandem mass spectrometry we showed recently, that the chromosomal deletion or inactivation of the methylthioadenosine phosphorylase (MTAP) gene led to the accumulation of 5'-deoxy-5'-(methylthio)adenosine (MTA) in cancer cells. Here, we expanded the method to other key intermediates of the methionine and polyamine pathways to further elucidate the molecular consequences of a lack of MTAP activity. Employing multiple-reaction monitoring, limits of detection and lower limits of quantification in the range of 2.5-100 and 5.0-500 nM, respectively, were achieved according to the guidelines of the FDA, thus enabling the direct measurement of the metabolites in biological samples without prior enrichment and derivatization with an analytical repeatability of 1-3%. Relative standards deviations for quadruplicate 80% methanol extractions of metabolites from cultured tumor cells ranged from 1.1 to 25.5%, while the combined methodological and biological variability in metabolite concentrations in 10 liver biopsies was 11.8-51.4%. The method enabled the demonstration of changes in the concentration of intermediates of the methionine and polyamine metabolism other than MTA in hepatocellular carcinoma specimens lacking the enzyme MTAP compared to normal liver tissue." @default.
• W2025066818 created "2016-06-24" @default.
• W2025066818 creator A5022275810 @default.
• W2025066818 creator A5042444056 @default.
• W2025066818 creator A5050903496 @default.
• W2025066818 creator A5059091265 @default.
• W2025066818 creator A5060264183 @default.
• W2025066818 creator A5081082077 @default.
• W2025066818 creator A5081742830 @default.
• W2025066818 date "2010-05-01" @default.
• W2025066818 modified "2023-10-17" @default.
• W2025066818 title "Quantification of intermediates of the methionine and polyamine metabolism by liquid chromatography–tandem mass spectrometry in cultured tumor cells and liver biopsies" @default.
• W2025066818 cites W1603847643 @default.
• W2025066818 cites W1970419068 @default.
• W2025066818 cites W1974918688 @default.
• W2025066818 cites W1980601429 @default.
• W2025066818 cites W1993550860 @default.
• W2025066818 cites W1994313286 @default.
• W2025066818 cites W2004572792 @default.
• W2025066818 cites W2004959159 @default.
• W2025066818 cites W2017738832 @default.
• W2025066818 cites W2023152559 @default.
• W2025066818 cites W2030791204 @default.
• W2025066818 cites W2037520415 @default.
• W2025066818 cites W2038454425 @default.
• W2025066818 cites W2057844885 @default.
• W2025066818 cites W2070454905 @default.
• W2025066818 cites W2074854597 @default.
• W2025066818 cites W2080738906 @default.
• W2025066818 cites W2089370234 @default.
• W2025066818 cites W2099817964 @default.
• W2025066818 cites W2101463846 @default.
• W2025066818 cites W2110851571 @default.
• W2025066818 cites W2127173080 @default.
• W2025066818 cites W2137201533 @default.
• W2025066818 cites W2151667576 @default.
• W2025066818 cites W1983577021 @default.
• W2025066818 doi "https://doi.org/10.1016/j.chroma.2010.01.025" @default.
• W2025066818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20117790" @default.
• W2025066818 hasPublicationYear "2010" @default.
• W2025066818 type Work @default.
• W2025066818 sameAs 2025066818 @default.
• W2025066818 citedByCount "40" @default.
• W2025066818 countsByYear W20250668182012 @default.
• W2025066818 countsByYear W20250668182013 @default.
• W2025066818 countsByYear W20250668182014 @default.
• W2025066818 countsByYear W20250668182015 @default.
• W2025066818 countsByYear W20250668182016 @default.
• W2025066818 countsByYear W20250668182017 @default.
• W2025066818 countsByYear W20250668182018 @default.
• W2025066818 countsByYear W20250668182019 @default.
• W2025066818 countsByYear W20250668182020 @default.
• W2025066818 countsByYear W20250668182021 @default.
• W2025066818 countsByYear W20250668182022 @default.
• W2025066818 crossrefType "journal-article" @default.
• W2025066818 hasAuthorship W2025066818A5022275810 @default.
• W2025066818 hasAuthorship W2025066818A5042444056 @default.
• W2025066818 hasAuthorship W2025066818A5050903496 @default.
• W2025066818 hasAuthorship W2025066818A5059091265 @default.
• W2025066818 hasAuthorship W2025066818A5060264183 @default.
• W2025066818 hasAuthorship W2025066818A5081082077 @default.
• W2025066818 hasAuthorship W2025066818A5081742830 @default.
• W2025066818 hasConcept C162356407 @default.
• W2025066818 hasConcept C181199279 @default.
• W2025066818 hasConcept C185592680 @default.
• W2025066818 hasConcept C21565614 @default.
• W2025066818 hasConcept C2776923573 @default.
• W2025066818 hasConcept C2777477808 @default.
• W2025066818 hasConcept C2777497464 @default.
• W2025066818 hasConcept C2780115381 @default.
• W2025066818 hasConcept C2780912031 @default.
• W2025066818 hasConcept C2781188418 @default.
• W2025066818 hasConcept C31827203 @default.
• W2025066818 hasConcept C43617362 @default.
• W2025066818 hasConcept C515207424 @default.
• W2025066818 hasConcept C55493867 @default.
• W2025066818 hasConcept C62231903 @default.
• W2025066818 hasConcept C64489805 @default.
• W2025066818 hasConceptScore W2025066818C162356407 @default.
• W2025066818 hasConceptScore W2025066818C181199279 @default.
• W2025066818 hasConceptScore W2025066818C185592680 @default.
• W2025066818 hasConceptScore W2025066818C21565614 @default.
• W2025066818 hasConceptScore W2025066818C2776923573 @default.
• W2025066818 hasConceptScore W2025066818C2777477808 @default.
• W2025066818 hasConceptScore W2025066818C2777497464 @default.
• W2025066818 hasConceptScore W2025066818C2780115381 @default.
• W2025066818 hasConceptScore W2025066818C2780912031 @default.
• W2025066818 hasConceptScore W2025066818C2781188418 @default.
• W2025066818 hasConceptScore W2025066818C31827203 @default.
• W2025066818 hasConceptScore W2025066818C43617362 @default.
• W2025066818 hasConceptScore W2025066818C515207424 @default.
• W2025066818 hasConceptScore W2025066818C55493867 @default.
• W2025066818 hasConceptScore W2025066818C62231903 @default.
• W2025066818 hasConceptScore W2025066818C64489805 @default.
• W2025066818 hasIssue "19" @default.
• W2025066818 hasLocation W20250668181 @default.
• W2025066818 hasLocation W20250668182 @default.
• W2025066818 hasOpenAccess W2025066818 @default.

• next