FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025078412> ?p ?o ?g. }

• W2025078412 endingPage "57" @default.
• W2025078412 startingPage "50" @default.
• W2025078412 abstract "Successful treatment of hepatitis C virus (HCV) infection is necessary for the survival of HIV-infected patients. This review covers the outcomes of current therapy, first-generation HCV direct-acting antivirals (DAAs) and their drug-to-drug interactions (DDIs). Understanding DDIs between HIV antiretroviral therapy (ART) and the DAAs in development is important to assure the best management of the HIV/HCV coinfected individuals.The two first-in-class DAAs were approved for clinical use in 2011. The first trials with boceprevir or telaprevir added to standard therapy in HIV/HCV coinfected patients revealed triple therapy to be efficacious with significantly improved sustained virological response rates. However, these DAAs were associated with more and worse adverse effects, as well as with significant DDIs with multiple drugs, including ART. Early data on DAAs in development suggest improved efficacy and safety and the potential for lesser DDIs.Anti-HCV therapy is fundamental in coinfected patients, but the approved therapies are suboptimal. The first-generation of approved HCV DAAs improved efficacy of therapy in coinfected patients, but have multiple safety concerns, including potentially serious drug interactions with ART. Early results from newer DAAs are promising." @default.
• W2025078412 created "2016-06-24" @default.
• W2025078412 creator A5054070286 @default.
• W2025078412 date "2013-02-01" @default.
• W2025078412 modified "2023-10-18" @default.
• W2025078412 title "Focus on drug interactions" @default.
• W2025078412 cites W1967977640 @default.
• W2025078412 cites W1976462318 @default.
• W2025078412 cites W1984556946 @default.
• W2025078412 cites W1993484328 @default.
• W2025078412 cites W1993607717 @default.
• W2025078412 cites W1995414702 @default.
• W2025078412 cites W1996434966 @default.
• W2025078412 cites W2002099217 @default.
• W2025078412 cites W2020159261 @default.
• W2025078412 cites W2023629303 @default.
• W2025078412 cites W2026051181 @default.
• W2025078412 cites W2036313720 @default.
• W2025078412 cites W2038647399 @default.
• W2025078412 cites W2045592358 @default.
• W2025078412 cites W2046658390 @default.
• W2025078412 cites W2052042782 @default.
• W2025078412 cites W2054470549 @default.
• W2025078412 cites W2062563125 @default.
• W2025078412 cites W2062868571 @default.
• W2025078412 cites W2085652845 @default.
• W2025078412 cites W2097073538 @default.
• W2025078412 cites W2099843722 @default.
• W2025078412 cites W2103638317 @default.
• W2025078412 cites W2116614776 @default.
• W2025078412 cites W2116705947 @default.
• W2025078412 cites W2118771356 @default.
• W2025078412 cites W2119168386 @default.
• W2025078412 cites W2121595515 @default.
• W2025078412 cites W2122764811 @default.
• W2025078412 cites W2124151787 @default.
• W2025078412 cites W2125963799 @default.
• W2025078412 cites W2130867228 @default.
• W2025078412 cites W2141214317 @default.
• W2025078412 cites W2142014128 @default.
• W2025078412 cites W2143559032 @default.
• W2025078412 cites W2157961528 @default.
• W2025078412 cites W2163606686 @default.
• W2025078412 cites W2164437680 @default.
• W2025078412 cites W2165305306 @default.
• W2025078412 cites W2165374230 @default.
• W2025078412 cites W2166962970 @default.
• W2025078412 cites W2167290108 @default.
• W2025078412 cites W2171945301 @default.
• W2025078412 doi "https://doi.org/10.1097/qco.0b013e32835c2027" @default.
• W2025078412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23242341" @default.
• W2025078412 hasPublicationYear "2013" @default.
• W2025078412 type Work @default.
• W2025078412 sameAs 2025078412 @default.
• W2025078412 citedByCount "12" @default.
• W2025078412 countsByYear W20250784122013 @default.
• W2025078412 countsByYear W20250784122014 @default.
• W2025078412 countsByYear W20250784122015 @default.
• W2025078412 countsByYear W20250784122016 @default.
• W2025078412 crossrefType "journal-article" @default.
• W2025078412 hasAuthorship W2025078412A5054070286 @default.
• W2025078412 hasBestOaLocation W20250784121 @default.
• W2025078412 hasConcept C126322002 @default.
• W2025078412 hasConcept C142462285 @default.
• W2025078412 hasConcept C159047783 @default.
• W2025078412 hasConcept C177713679 @default.
• W2025078412 hasConcept C197934379 @default.
• W2025078412 hasConcept C2522874641 @default.
• W2025078412 hasConcept C2776408679 @default.
• W2025078412 hasConcept C2776455275 @default.
• W2025078412 hasConcept C2776999253 @default.
• W2025078412 hasConcept C2777159539 @default.
• W2025078412 hasConcept C2778159067 @default.
• W2025078412 hasConcept C2780035454 @default.
• W2025078412 hasConcept C2780040827 @default.
• W2025078412 hasConcept C2993143319 @default.
• W2025078412 hasConcept C3013748606 @default.
• W2025078412 hasConcept C535046627 @default.
• W2025078412 hasConcept C71924100 @default.
• W2025078412 hasConcept C98274493 @default.
• W2025078412 hasConceptScore W2025078412C126322002 @default.
• W2025078412 hasConceptScore W2025078412C142462285 @default.
• W2025078412 hasConceptScore W2025078412C159047783 @default.
• W2025078412 hasConceptScore W2025078412C177713679 @default.
• W2025078412 hasConceptScore W2025078412C197934379 @default.
• W2025078412 hasConceptScore W2025078412C2522874641 @default.
• W2025078412 hasConceptScore W2025078412C2776408679 @default.
• W2025078412 hasConceptScore W2025078412C2776455275 @default.
• W2025078412 hasConceptScore W2025078412C2776999253 @default.
• W2025078412 hasConceptScore W2025078412C2777159539 @default.
• W2025078412 hasConceptScore W2025078412C2778159067 @default.
• W2025078412 hasConceptScore W2025078412C2780035454 @default.
• W2025078412 hasConceptScore W2025078412C2780040827 @default.
• W2025078412 hasConceptScore W2025078412C2993143319 @default.
• W2025078412 hasConceptScore W2025078412C3013748606 @default.
• W2025078412 hasConceptScore W2025078412C535046627 @default.
• W2025078412 hasConceptScore W2025078412C71924100 @default.
• W2025078412 hasConceptScore W2025078412C98274493 @default.

• next