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• W2025084949 startingPage "45" @default.
• W2025084949 abstract "Oropharyngeal candidiasis (OPC), caused primarily by Candida albicans, is the most common oral infection in HIV + persons. Although Th1-type CD4 + T cells are the predominant host defense mechanism against OPC, CD8 + T cells and epithelial cells become important when blood CD4 + T cells are reduced below a protective threshold during progression to AIDS. In an early cross-sectional study, OPC + tissue biopsied from HIV + persons had an accumulation of activated memory CD8 + T cells at the oral epithelial–lamina propria interface, with reduced expression of the adhesion molecule E-cadherin, suggesting a protective role for CD8 + T cells but a dysfunction in the mucosal migration of the cells. In a subsequent 1-year longitudinal study, OPC − patients with high oral Candida colonization (indicative of a preclinical OPC condition), had higher numbers of CD8 + T cells distributed throughout the tissue, with normal E-cadherin expression. In OPC + patients, where lack of CD8 + T cell migration was associated with reduced E-cadherin, subsequent evaluations following successful treatment of infection revealed normal E-cadherin expression and cellular distribution. Regarding epithelial cell responses, intact oral epithelial cells exhibit fungistatic activity via an acid-labile protein moiety. A proteomic analysis revealed that annexin A1 is a strong candidate for the effector moiety. The current hypothesis is that under reduced CD4 + T cells, HIV + persons protected from OPC have CD8 + T cells that migrate to the site of a preclinical infection under normal expression of E-cadherin, whereas those with OPC have a transient reduction in E-cadherin that prohibits CD8 + T cells from migrating for effector function. Oral epithelial cells concomitantly function through annexin A1 to keep Candida in a commensal state but can easily be overwhelmed, thereby contributing to susceptibility to OPC." @default.
• W2025084949 created "2016-06-24" @default.
• W2025084949 creator A5003012080 @default.
• W2025084949 date "2011-03-25" @default.
• W2025084949 modified "2023-10-01" @default.
• W2025084949 title "<i>Candida</i>-Host Interactions in HIV Disease" @default.
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• W2025084949 doi "https://doi.org/10.1177/0022034511399284" @default.
• W2025084949 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3144040" @default.
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