Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025086213> ?p ?o ?g. }
- W2025086213 endingPage "1189" @default.
- W2025086213 startingPage "1177" @default.
- W2025086213 abstract "The majority of evidence supports the conclusion that IgG-dependent effectors respond to antibodies which have been polymerized artificially or by polyvalent antigens, but not to monomeric IgG antibodies. Effectors can distinguish polymerized IgG antibodies from monomeric IgG because they contain multiple receptor units and can interact multivalently with polymerized IgG. However, monomeric IgG is present at very high concns in plasma and interstitial fluids and will inhibit multivalent interactions in vivo between polymerized antibody and effectors. Such inhibition raises the question of how IgG-mediated effector responses could function in vivo. In this review we present a mathematical model which quantitatively predicts how polyvalent ligands interact multivalently with receptors in the presence of excess monovalent ligand. We then show that results from experiments in vitro using such diverse systems as the binding and endocytosis of immune complexes by macrophages, complement-mediated lysis of antibody-coated target cells, and ADCC can be explained qualitatively by the model. We conclude that monomeric IgG does not totally inhibit IgG-mediated effector functions but, rather, raises the threshold of antibody binding which is required to elicit a response. We then consider how non-immune IgG may serve as a homeostatic regulator of IgG-dependent responses, in vivo, perhaps for the purpose of inhibiting responses to low levels of cell-bound IgG autoantibodies." @default.
- W2025086213 created "2016-06-24" @default.
- W2025086213 creator A5009580916 @default.
- W2025086213 creator A5016538596 @default.
- W2025086213 creator A5049777439 @default.
- W2025086213 date "1983-11-01" @default.
- W2025086213 modified "2023-10-16" @default.
- W2025086213 title "The role of non-immune IgG in controlling IgG-mediated effector functions" @default.
- W2025086213 cites W105028306 @default.
- W2025086213 cites W117141673 @default.
- W2025086213 cites W1430020543 @default.
- W2025086213 cites W1575019562 @default.
- W2025086213 cites W1587036935 @default.
- W2025086213 cites W1606393145 @default.
- W2025086213 cites W1795584448 @default.
- W2025086213 cites W180425777 @default.
- W2025086213 cites W1840837207 @default.
- W2025086213 cites W1969002000 @default.
- W2025086213 cites W1970739151 @default.
- W2025086213 cites W1980939469 @default.
- W2025086213 cites W1982224775 @default.
- W2025086213 cites W1983049753 @default.
- W2025086213 cites W1989404582 @default.
- W2025086213 cites W1992151461 @default.
- W2025086213 cites W1997250042 @default.
- W2025086213 cites W1999480704 @default.
- W2025086213 cites W2003921158 @default.
- W2025086213 cites W2006040039 @default.
- W2025086213 cites W2007232603 @default.
- W2025086213 cites W2007997507 @default.
- W2025086213 cites W2011500156 @default.
- W2025086213 cites W2014467278 @default.
- W2025086213 cites W2016097410 @default.
- W2025086213 cites W2033288571 @default.
- W2025086213 cites W2036362341 @default.
- W2025086213 cites W2040455422 @default.
- W2025086213 cites W2047184374 @default.
- W2025086213 cites W2047237671 @default.
- W2025086213 cites W2052192720 @default.
- W2025086213 cites W2054765306 @default.
- W2025086213 cites W2057141478 @default.
- W2025086213 cites W2057816117 @default.
- W2025086213 cites W2063305377 @default.
- W2025086213 cites W2066091036 @default.
- W2025086213 cites W2068378281 @default.
- W2025086213 cites W2068941192 @default.
- W2025086213 cites W2079687293 @default.
- W2025086213 cites W2084333808 @default.
- W2025086213 cites W2085369521 @default.
- W2025086213 cites W2086236357 @default.
- W2025086213 cites W208907758 @default.
- W2025086213 cites W2090338453 @default.
- W2025086213 cites W2109243910 @default.
- W2025086213 cites W2119198419 @default.
- W2025086213 cites W2127552260 @default.
- W2025086213 cites W2128184463 @default.
- W2025086213 cites W2166330681 @default.
- W2025086213 cites W2772215231 @default.
- W2025086213 cites W279470183 @default.
- W2025086213 cites W40510501 @default.
- W2025086213 cites W4231797090 @default.
- W2025086213 cites W4239088562 @default.
- W2025086213 cites W97674068 @default.
- W2025086213 cites W1986098772 @default.
- W2025086213 doi "https://doi.org/10.1016/0161-5890(83)90141-4" @default.
- W2025086213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6228721" @default.
- W2025086213 hasPublicationYear "1983" @default.
- W2025086213 type Work @default.
- W2025086213 sameAs 2025086213 @default.
- W2025086213 citedByCount "34" @default.
- W2025086213 crossrefType "journal-article" @default.
- W2025086213 hasAuthorship W2025086213A5009580916 @default.
- W2025086213 hasAuthorship W2025086213A5016538596 @default.
- W2025086213 hasAuthorship W2025086213A5049777439 @default.
- W2025086213 hasConcept C147483822 @default.
- W2025086213 hasConcept C150903083 @default.
- W2025086213 hasConcept C159654299 @default.
- W2025086213 hasConcept C163764329 @default.
- W2025086213 hasConcept C170493617 @default.
- W2025086213 hasConcept C185592680 @default.
- W2025086213 hasConcept C203014093 @default.
- W2025086213 hasConcept C207001950 @default.
- W2025086213 hasConcept C2780898057 @default.
- W2025086213 hasConcept C28005876 @default.
- W2025086213 hasConcept C40677261 @default.
- W2025086213 hasConcept C51785407 @default.
- W2025086213 hasConcept C542903549 @default.
- W2025086213 hasConcept C55493867 @default.
- W2025086213 hasConcept C86803240 @default.
- W2025086213 hasConcept C8891405 @default.
- W2025086213 hasConcept C95444343 @default.
- W2025086213 hasConceptScore W2025086213C147483822 @default.
- W2025086213 hasConceptScore W2025086213C150903083 @default.
- W2025086213 hasConceptScore W2025086213C159654299 @default.
- W2025086213 hasConceptScore W2025086213C163764329 @default.
- W2025086213 hasConceptScore W2025086213C170493617 @default.
- W2025086213 hasConceptScore W2025086213C185592680 @default.
- W2025086213 hasConceptScore W2025086213C203014093 @default.