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- W2025088099 abstract "Abstract The pilocarpine rat brain model is a well-studied model of temporal lobe epilepsy. The purposes of this study were: (1) to estimate the brain metabolite concentration changes in the hippocampus of pilocarpine rats by Magnetic Resonance Spectroscopy, 24 h (acute phase) and 2 months (chronic phase) after the onset of Status Epilepticus ; (2) to compare the metabolite concentration estimates to those obtained from healthy rats. In vivo short echo-time signals of epileptic and healthy rat brains were acquired at 7 T in the hippocampus. A statistically significant increase of lactate concentration was quantified 24 h after Status Epilepticus . The N -acetylaspartate concentrations slightly decreased in the acute phase, continuing to decrease in the chronic phase, resulting in a statistically significant loss compared to the healthy rat brains." @default.
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- W2025088099 date "2008-04-01" @default.
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- W2025088099 title "Brain metabolite concentration estimates using Magnetic Resonance Spectroscopy in a chronic model of temporal lobe epilepsy" @default.
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- W2025088099 doi "https://doi.org/10.1016/j.crci.2007.11.002" @default.
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