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- W2025093756 abstract "We have recently reported a connection between the expression of the Werner syndrome gene (WRN), whose loss of function has been implicated in a human progeroid syndrome (WS), and the Myc oncoprotein. Myc overexpression directly elevates trancription of the WRN gene, whose presence is required to avoid senescence during Myc proliferative stimuli. Here we discuss several hypotheses to explain why WRN might be required to support oncogenic proliferation in light of the known function of WRNprotein and Myc in genomic instability and transcriptional modulation. In addition, we address the apparent paradox of why patients with WS, lacking WRN function, have increased incidence of certain cancers." @default.
- W2025093756 created "2016-06-24" @default.
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- W2025093756 date "2004-01-01" @default.
- W2025093756 modified "2023-09-25" @default.
- W2025093756 title "Functional Link Between Myc and the Werner Gene in Tumorigenesis" @default.
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- W2025093756 doi "https://doi.org/10.4161/cc.3.1.630" @default.
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