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- W2025094865 abstract "The Dutch Parelsnoer Initiative (PI: www.Parelsnoer.org) is a unique collaboration between the eight Dutch University Medical Centers (UMCs) in which clinical data and biomaterials from patients suffering from one of nine chronic diseases are collected according to harmonized protocols. The aim of the PI is to set up a nationwide biobank infrastructure that will be used for scientific research related to early diagnostics, improvement of treatment and to encourage the development of new products. Neurodegenerative diseases form one of the nine disorders studied in PI. The Pearl Neurodegenerative Diseases (PND) focuses on the role of biomarkers in the early diagnosis and in monitoring the course of neurodegenerative diseases, in particular in AD. Here we describe the methods and the general set-up of the PND. The PND is a 2-year follow-up study of 800 patients. Inclusion criteria are: patients referred to a memory clinic of an UMC with cognitive complaints, a Clinical Dementia Rating (CDR) scale of 0, 0.5, or 1 and a Mini Mental State Examination (MMSE) of = 20. This implicates that most patients will be mentally competent. Patients with vascular dementia are excluded. At baseline, all patients will be subjected to a standardized examination, including: general information, medical history, MMSE, CDR, Neuropsychiatric Inventory, Geriatric Depression Scale, Disability Assessment for Dementia, Quality of life, an extensive neuropsychological test battery, blood samples, MRI and CSF (in case of informed consent). Clinical data are collected at 1 and 2-year follow-up. Blood, CSF and MRI will be repeated at the 2-year follow-up only. Data collection is still ongoing until the end of 2011. At this moment about 600 patients have been included and the 1-year follow-up has started. Specific research questions are being proposed and it is expected that issue of the first data will be in the summer of 2011. The PND is a large Dutch network collecting clinical data, MRI, blood and CSF of 800 patients with subjective and/or objective cognitive impairments. This unique dataset makes it possible to perform nationwide high quality research into neurodegenerative diseases." @default.
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- W2025094865 date "2011-07-01" @default.
- W2025094865 modified "2023-10-06" @default.
- W2025094865 title "P2-114: Biomarkers in neurodegenerative diseases: The Dutch Parelsnoer Initiative" @default.
- W2025094865 doi "https://doi.org/10.1016/j.jalz.2011.05.1002" @default.
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