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- W2025098483 startingPage "218" @default.
- W2025098483 abstract "<h3>ABSTRACT</h3> The microorganisms that inhabit human skin, collectively termed the skin microbiome, must overcome numerous challenges that typically impede microbial growth, including low pH, osmotic pressure, and low nutrient availability. Yet, the skin microbiota thrive on the skin and have adapted to these stressful conditions. Limited skin nutrients are available for microbial use in this unique niche, including those from host-derived sweat, sebum, and corneocytes. Here, we have developed physiologically-relevant, skin-like growth media that is composed of compounds present in human sweat and sebum. We find that skin-associated bacterial species exhibit unique growth profiles in different concentrations of sweat and sebum. The majority of strains evaluated demonstrate a preference for high sweat concentrations, while sebum preference is highly variable, suggesting that the capacity for sebum utilization may be an important driver of skin microbial community structure. Furthermore, these findings provide experimental rationale for why different skin microenvironments harbor distinct microbiome communities. In all, our study further emphasizes the importance of studying microorganisms in an ecologically-relevant context, which is critical for our understanding of their physiology, ecology, and function on the skin." @default.
- W2025098483 created "2016-06-24" @default.
- W2025098483 creator A5075982815 @default.
- W2025098483 date "1976-01-24" @default.
- W2025098483 modified "2023-09-25" @default.
- W2025098483 title "Letter: Aetiology of anencephaly and spina bifida." @default.
- W2025098483 cites W1991270103 @default.
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- W2025098483 doi "https://doi.org/10.1136/bmj.1.6003.218-a" @default.
- W2025098483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1638442" @default.
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