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- W2025100620 abstract "Abstract 1. 1. Pretreatment of chick-embryo liver cell cultures with inducers of the drug-metabolizing enzyme system markedly stimulates the accumulation of porphyrins after exposure to polyhalogenated hydrocarbons. 2. 2. Inhibition of hepatic drug metabolism or addition of compounds which are known to trap electrophiles or radicals protects against the porphyrinogenic action of polyhalogenated hydrocarbons in vitro . A reactive intermediate formed by metabolism of the polyhalogenated hydrocarbon is suggested to react with the catalytic SH-containing part of the uroporphyrinogen decarboxylating enzyme in the liver cytosol. 3. 3. The consequent inhibition of uroporphyrinogen decarboxylase, which leads to porphyrin accumulation, may be a very first indication of cellular damage caused by toxic metabolites of these compounds. 4. 4. The results of this work with the chick embryo liver cell system are in good agreement with the observations in animal experiments." @default.
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- W2025100620 date "1980-01-01" @default.
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- W2025100620 title "Metabolism as a prerequisite for the porphyrinogenic action of polyhalogenated aromatics, with special reference to hexachlorobenzene and polybrominated biphenyls (Firemaster BP-6)" @default.
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- W2025100620 doi "https://doi.org/10.1016/0020-711x(80)90205-0" @default.
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