Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025106893> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2025106893 endingPage "5462" @default.
- W2025106893 startingPage "5459" @default.
- W2025106893 abstract "Abstract. Agouti related peptide (Agrp), the endogenous antagonist of the melanocortin 3 and 4 receptors (MC3-R and MC4-R), is expressed at high levels in the arcuate nucleus. Agrp immunoreactive terminals are found in the medial preoptic area (MPO), an area that also contains luteinizing hormone releasing hormone (LHRH) neurons. This study was designed to examine the action of Agrp and αMSH on gonadotropin release in vivo following intracerebroventricular (ICV) injection and on LHRH and luteinizing hormone (LH) release in vitro in male rats. We report that ICV administration of Agrp (83–132) significantly increased plasma LH at 40 min post-injection (Agrp (83–132) 2 nmol 0.6 ± 0.1 vs. saline 0.4 ± 0.02 ng/ml, p < 0.05). Plasma follicle stimulating hormone (FSH) was also significantly increased by Agrp (83–132) at 40 min post-injection (Agrp (83–132) 2 nmol 15.6 ± 2.1 ng/ml vs. saline 9.6 ± 1.1 ng/ml, p < 0.05). Agrp (83–132) significantly stimulated the release of LHRH from medial basal hypothalamic explants (Agrp (83–132) 100 nM 170 ± 23% vs. control 100 ± 20%, p < 0.05). In contrast, Agrp (83–132) (0.1–100 nM) had no effect on either basal or LHRH-stimulated LH release from dispersed anterior pituitary cells (Agrp (83–132) 100 nM 10 ± 0.4 ng/ml vs. control 12 ± 1.3 ng/ml, p = ns; LHRH 10 nM + Agrp (83–132) 100 nM 28 ± 1.5 ng/ml vs. LHRH 10 nM 28 ± 1.2 ng/ml, p = ns). We have demonstrated that Agrp (83–132), which blocks melanocortin receptors, significantly increases plasma LH and FSH following ICV administration and stimulates LHRH release from hypothalamic explants but has no direct effect on LH release from dispersed anterior pituitary cells. These results suggest that the melanocortin system plays a role in the control of the hypothalamo-pituitary gonadal axis and may act as a link between the control of appetite and reproductive function." @default.
- W2025106893 created "2016-06-24" @default.
- W2025106893 creator A5011196462 @default.
- W2025106893 creator A5014580425 @default.
- W2025106893 creator A5024304668 @default.
- W2025106893 creator A5061881474 @default.
- W2025106893 creator A5068514336 @default.
- W2025106893 creator A5070020246 @default.
- W2025106893 creator A5073713208 @default.
- W2025106893 creator A5074018233 @default.
- W2025106893 date "1999-11-01" @default.
- W2025106893 modified "2023-09-25" @default.
- W2025106893 title "Agouti Related Peptide (Agrp) Stimulates the Hypothalamo Pituitary Gonadal Axis in Vivo & in Vitro in Male Rats" @default.
- W2025106893 doi "https://doi.org/10.1210/endo.140.11.7248" @default.
- W2025106893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10537182" @default.
- W2025106893 hasPublicationYear "1999" @default.
- W2025106893 type Work @default.
- W2025106893 sameAs 2025106893 @default.
- W2025106893 citedByCount "64" @default.
- W2025106893 countsByYear W20251068932012 @default.
- W2025106893 countsByYear W20251068932013 @default.
- W2025106893 countsByYear W20251068932014 @default.
- W2025106893 countsByYear W20251068932015 @default.
- W2025106893 countsByYear W20251068932017 @default.
- W2025106893 countsByYear W20251068932020 @default.
- W2025106893 countsByYear W20251068932021 @default.
- W2025106893 countsByYear W20251068932022 @default.
- W2025106893 crossrefType "journal-article" @default.
- W2025106893 hasAuthorship W2025106893A5011196462 @default.
- W2025106893 hasAuthorship W2025106893A5014580425 @default.
- W2025106893 hasAuthorship W2025106893A5024304668 @default.
- W2025106893 hasAuthorship W2025106893A5061881474 @default.
- W2025106893 hasAuthorship W2025106893A5068514336 @default.
- W2025106893 hasAuthorship W2025106893A5070020246 @default.
- W2025106893 hasAuthorship W2025106893A5073713208 @default.
- W2025106893 hasAuthorship W2025106893A5074018233 @default.
- W2025106893 hasBestOaLocation W20251068931 @default.
- W2025106893 hasConcept C126322002 @default.
- W2025106893 hasConcept C134018914 @default.
- W2025106893 hasConcept C150903083 @default.
- W2025106893 hasConcept C185592680 @default.
- W2025106893 hasConcept C207001950 @default.
- W2025106893 hasConcept C2777003273 @default.
- W2025106893 hasConcept C2777397205 @default.
- W2025106893 hasConcept C2778024521 @default.
- W2025106893 hasConcept C2778575703 @default.
- W2025106893 hasConcept C2778894405 @default.
- W2025106893 hasConcept C2779306644 @default.
- W2025106893 hasConcept C71315377 @default.
- W2025106893 hasConcept C71924100 @default.
- W2025106893 hasConcept C86803240 @default.
- W2025106893 hasConceptScore W2025106893C126322002 @default.
- W2025106893 hasConceptScore W2025106893C134018914 @default.
- W2025106893 hasConceptScore W2025106893C150903083 @default.
- W2025106893 hasConceptScore W2025106893C185592680 @default.
- W2025106893 hasConceptScore W2025106893C207001950 @default.
- W2025106893 hasConceptScore W2025106893C2777003273 @default.
- W2025106893 hasConceptScore W2025106893C2777397205 @default.
- W2025106893 hasConceptScore W2025106893C2778024521 @default.
- W2025106893 hasConceptScore W2025106893C2778575703 @default.
- W2025106893 hasConceptScore W2025106893C2778894405 @default.
- W2025106893 hasConceptScore W2025106893C2779306644 @default.
- W2025106893 hasConceptScore W2025106893C71315377 @default.
- W2025106893 hasConceptScore W2025106893C71924100 @default.
- W2025106893 hasConceptScore W2025106893C86803240 @default.
- W2025106893 hasIssue "11" @default.
- W2025106893 hasLocation W20251068931 @default.
- W2025106893 hasLocation W20251068932 @default.
- W2025106893 hasOpenAccess W2025106893 @default.
- W2025106893 hasPrimaryLocation W20251068931 @default.
- W2025106893 hasRelatedWork W1953592402 @default.
- W2025106893 hasRelatedWork W1977948924 @default.
- W2025106893 hasRelatedWork W1983047987 @default.
- W2025106893 hasRelatedWork W2036239614 @default.
- W2025106893 hasRelatedWork W2054119993 @default.
- W2025106893 hasRelatedWork W2056116732 @default.
- W2025106893 hasRelatedWork W2057304712 @default.
- W2025106893 hasRelatedWork W2070279303 @default.
- W2025106893 hasRelatedWork W2118001750 @default.
- W2025106893 hasRelatedWork W2411332413 @default.
- W2025106893 hasVolume "140" @default.
- W2025106893 isParatext "false" @default.
- W2025106893 isRetracted "false" @default.
- W2025106893 magId "2025106893" @default.
- W2025106893 workType "article" @default.