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• W2025114242 abstract "Uterine natural killer (uNK) cells have roles for immune responses at the feto-maternal interface in mice. We studied the effects of β2-microglobulin (β2m) and perforin on proliferation and differentiation of uNK cells in pregnancy, using β2-microglobulin-deficient (β2m-/-) mice and perforin-deficient (P-/-) mice. The cell population of uNK cells in the metrial gland of P-/- mice was tended to be higher than the control B6 mice. The cell population of uNK cells in the metrial gland of β2m-/- mice was significantly increased at Day 12 of pregnancy comparing to B6 and P-/- mice. On the other hand, the cell population of uNK cells in the decidua basalis of β2m-/- mice was tended to be lower than B6 and P-/- mice. These results indicate that β2m may be involved in proliferation of uNK cells in the metrial gland, and that β2m may affect the maturation of uNK cells in the decidua basalis." @default.
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• W2025114242 date "2009-01-01" @default.
• W2025114242 modified "2023-10-18" @default.
• W2025114242 title "Uterine Natural Killer Cells in Perforin and .BETA.2-Microglobulin Deficient Mice" @default.
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• W2025114242 doi "https://doi.org/10.1292/jvms.71.251" @default.
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