FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025115429> ?p ?o ?g. }

• W2025115429 endingPage "303" @default.
• W2025115429 startingPage "298" @default.
• W2025115429 abstract "MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces parkinsonism in humans and animals. The effects of zonisamide on dopamine neurons were studied in MPTP-treated common marmosets (Callithrix jacchus). Groups of animals (n = 3) were treated with MPTP (2.5 mg/kg, every 24 h × 3); MPTP plus zonisamide (40 mg/kg administered 1 h before each MPTP dose); MPTP plus selegiline (a known MAO-B inhibitor) (2 mg/kg administered 1 h before each MPTP dose); and saline controls. An immunohistochemical study of the substantia nigra was performed 14 days after MPTP treatment in each group. MPTP reduced the mean number of tyrosine hydroxylase (TH)-positive neurons to 10% of the normal control group and mean cell size was significantly (P < 0.001) reduced from 424 to 159 μm2. In the group pre-treated with zonisamide, the mean number of TH-positive neurons was reduced to 26% of that in the normal control group and the mean neuron size was significantly (P < 0.05) increased from 159 to 273 μm2 compared with the group treated with MPTP alone. Moreover, in the group pre-treated with selegiline, the mean number of TH-positive neurons was 47% of that in the normal control group and the mean neuron size was increased significantly (P < 0.01) from159 to 319 μm2 compared to the group treated with MPTP alone. This observation suggests that zonisamide reduces MPTP toxicity." @default.
• W2025115429 created "2016-06-24" @default.
• W2025115429 creator A5012662508 @default.
• W2025115429 creator A5023952262 @default.
• W2025115429 creator A5027866038 @default.
• W2025115429 creator A5047410499 @default.
• W2025115429 creator A5049747372 @default.
• W2025115429 creator A5070763753 @default.
• W2025115429 creator A5071331057 @default.
• W2025115429 creator A5080278594 @default.
• W2025115429 date "2010-01-01" @default.
• W2025115429 modified "2023-10-18" @default.
• W2025115429 title "Zonisamide Attenuates MPTP Neurotoxicity in Marmosets" @default.
• W2025115429 cites W1991720146 @default.
• W2025115429 cites W2005102504 @default.
• W2025115429 cites W2018560973 @default.
• W2025115429 cites W2022264559 @default.
• W2025115429 cites W2026715162 @default.
• W2025115429 cites W2032144918 @default.
• W2025115429 cites W2045698358 @default.
• W2025115429 cites W2046051823 @default.
• W2025115429 cites W2048914375 @default.
• W2025115429 cites W2049083444 @default.
• W2025115429 cites W2052808719 @default.
• W2025115429 cites W2052946879 @default.
• W2025115429 cites W2053666892 @default.
• W2025115429 cites W2067075698 @default.
• W2025115429 cites W2067901223 @default.
• W2025115429 cites W2068361353 @default.
• W2025115429 cites W2076275030 @default.
• W2025115429 cites W2082773995 @default.
• W2025115429 cites W2091626910 @default.
• W2025115429 cites W2091846875 @default.
• W2025115429 cites W2149105763 @default.
• W2025115429 cites W4210948843 @default.
• W2025115429 doi "https://doi.org/10.1254/jphs.10120fp" @default.
• W2025115429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20948167" @default.
• W2025115429 hasPublicationYear "2010" @default.
• W2025115429 type Work @default.
• W2025115429 sameAs 2025115429 @default.
• W2025115429 citedByCount "13" @default.
• W2025115429 countsByYear W20251154292012 @default.
• W2025115429 countsByYear W20251154292013 @default.
• W2025115429 countsByYear W20251154292015 @default.
• W2025115429 countsByYear W20251154292017 @default.
• W2025115429 countsByYear W20251154292019 @default.
• W2025115429 countsByYear W20251154292020 @default.
• W2025115429 countsByYear W20251154292021 @default.
• W2025115429 countsByYear W20251154292022 @default.
• W2025115429 crossrefType "journal-article" @default.
• W2025115429 hasAuthorship W2025115429A5012662508 @default.
• W2025115429 hasAuthorship W2025115429A5023952262 @default.
• W2025115429 hasAuthorship W2025115429A5027866038 @default.
• W2025115429 hasAuthorship W2025115429A5047410499 @default.
• W2025115429 hasAuthorship W2025115429A5049747372 @default.
• W2025115429 hasAuthorship W2025115429A5070763753 @default.
• W2025115429 hasAuthorship W2025115429A5071331057 @default.
• W2025115429 hasAuthorship W2025115429A5080278594 @default.
• W2025115429 hasBestOaLocation W20251154291 @default.
• W2025115429 hasConcept C118552586 @default.
• W2025115429 hasConcept C126322002 @default.
• W2025115429 hasConcept C134018914 @default.
• W2025115429 hasConcept C137183658 @default.
• W2025115429 hasConcept C159167319 @default.
• W2025115429 hasConcept C181199279 @default.
• W2025115429 hasConcept C185592680 @default.
• W2025115429 hasConcept C2776024655 @default.
• W2025115429 hasConcept C2776134090 @default.
• W2025115429 hasConcept C2777138316 @default.
• W2025115429 hasConcept C2777683783 @default.
• W2025115429 hasConcept C2778186239 @default.
• W2025115429 hasConcept C2778674702 @default.
• W2025115429 hasConcept C2779134260 @default.
• W2025115429 hasConcept C2779491297 @default.
• W2025115429 hasConcept C2779734285 @default.
• W2025115429 hasConcept C2780358027 @default.
• W2025115429 hasConcept C29730261 @default.
• W2025115429 hasConcept C39398028 @default.
• W2025115429 hasConcept C513476851 @default.
• W2025115429 hasConcept C55493867 @default.
• W2025115429 hasConcept C71924100 @default.
• W2025115429 hasConcept C98274493 @default.
• W2025115429 hasConceptScore W2025115429C118552586 @default.
• W2025115429 hasConceptScore W2025115429C126322002 @default.
• W2025115429 hasConceptScore W2025115429C134018914 @default.
• W2025115429 hasConceptScore W2025115429C137183658 @default.
• W2025115429 hasConceptScore W2025115429C159167319 @default.
• W2025115429 hasConceptScore W2025115429C181199279 @default.
• W2025115429 hasConceptScore W2025115429C185592680 @default.
• W2025115429 hasConceptScore W2025115429C2776024655 @default.
• W2025115429 hasConceptScore W2025115429C2776134090 @default.
• W2025115429 hasConceptScore W2025115429C2777138316 @default.
• W2025115429 hasConceptScore W2025115429C2777683783 @default.
• W2025115429 hasConceptScore W2025115429C2778186239 @default.
• W2025115429 hasConceptScore W2025115429C2778674702 @default.
• W2025115429 hasConceptScore W2025115429C2779134260 @default.
• W2025115429 hasConceptScore W2025115429C2779491297 @default.
• W2025115429 hasConceptScore W2025115429C2779734285 @default.

• next