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• W2025118912 abstract "HARMS, C, A., S. R. McCLARAN, G. A. NICKELE, D. F. PEGELOW, W. B. NELSON, and J. A. DEMPSEY. Effect of exercise-induced arterial O2 desaturation on V̇O2max in women. Med. Sci. Sports Exerc., Vol. 32, No. 6, pp. 1101–1108, 2000. Purpose We have recently reported that many healthy habitually active women experience exercise induced arterial hypoxemia (EIAH). We questioned whether EIAH affected V̇O2max in this population and whether the effect was similar to that reported in men. Methods Twenty-five healthy young women with widely varying fitness levels (V̇O2max, 56.7 ± 1.5 mL·kg−1·min−1; range: 41–70 mL·kg−1·min−1) and normal resting lung function performed two randomized incremental treadmill tests to V̇O2max (FIO2: 0.21 or 0.26) during the follicular phase of their menstrual cycle. Arterial blood samples were taken at rest and near the end of each workload during the normoxic test. Results During room air breathing at V̇O2max, SaO2 decreased to 91.8 ± 0.4% (range 87–95%). With 0.26 FIO2, SaO2 at V̇O2max remained near resting levels and averaged 96.8 ± 0.1% (range 96–98%). When arterial O2 desaturation was prevented via increased FIO2, V̇O2max increased in 22 of the 25 subjects and in proportion to the degree of arterial O2 desaturation experienced in normoxia (r = 0.88). The improvement in V̇O2max when systemic normoxia was maintained averaged 6.3 ± 0.3% (range 0 to +15%) and the slope of the relationship was ∼ 2% increase in V̇O2max for every 1% decrement in the arterial oxygen saturation below resting values. About 75% of the increase in V̇O2max resulted from an increase in V̇O2 at a fixed maximal work rate and exercise duration, and the remainder resulted from an increase in maximal work rate. Conclusions These data demonstrate that even small amounts of EIAH (i.e., >3% ΔSaO2 below rest) have a significant detrimental effect on V̇O2max in habitually active women with a wide range of V̇O2max. In combination with our previous findings documenting EIAH in females, we propose that inadequate pulmonary structure/function in many habitually active women serves as a primary limiting factor in maximal O2 transport and utilization during maximal exercise." @default.
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• W2025118912 title "Effect of exercise-induced arterial O2 desaturation on &OV0312;O2max in women" @default.
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• W2025118912 doi "https://doi.org/10.1097/00005768-200006000-00010" @default.
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