FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025122502> ?p ?o ?g. }

• W2025122502 endingPage "257" @default.
• W2025122502 startingPage "251" @default.
• W2025122502 abstract "BACKGROUND The p53-dependent G2/M checkpoint plays a key role in the maintenance of genomic integrity, thereby protecting cells from neoplastic progression. Reprimo, a gene involved in the p53-induced G2 cell cycle arrest, has been recently identified as a novel target for aberrant methylation in pancreatic and other cancers. The biological and clinical relevance of Reprimo methylation in pancreatic cancer was investigated. METHODS The methylation status of Reprimo CpG island was analyzed by methylation-specific polymerase chain reaction in a large series of pancreatic cancers and was correlated with p53 mutation status, genetic instability (as measured by the fractional allelic loss), and clinicopathologic features. RESULTS Aberrant methylation of Reprimo was identified in 60% (75 of 125) of pancreatic cancer xenografts and primary pancreatic adenocarcinomas. Reprimo methylation was also detectable in 30% (19 of 63) of pancreatic intraepithelial neoplasias (PanIN), known precursors to infiltrating carcinoma. Reprimo methylation was unrelated to the p53 mutation status and associated with the increased degree of genetic instability (P = .04). Furthermore, we found that patients with Reprimo methylation in their primary pancreatic cancers have significantly worse prognosis than those without Reprimo methylation (P = .007). In contrast, other methylation targets in pancreatic cancers (SPARC and CXCR4) did not correlate with prognosis. CONCLUSIONS These results suggest that aberrant methylation of Reprimo is a common event in pancreatic carcinogenesis and is associated with genetic instability and unfavorable outcome after surgical resection. Cancer 2006. © 2006 American Cancer Society." @default.
• W2025122502 created "2016-06-24" @default.
• W2025122502 creator A5005202372 @default.
• W2025122502 creator A5025415933 @default.
• W2025122502 creator A5036877791 @default.
• W2025122502 creator A5043757838 @default.
• W2025122502 creator A5078000437 @default.
• W2025122502 creator A5090286753 @default.
• W2025122502 date "2006-01-01" @default.
• W2025122502 modified "2023-10-14" @default.
• W2025122502 title "Aberrant methylation ofReprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma" @default.
• W2025122502 cites W1520203303 @default.
• W2025122502 cites W1596182601 @default.
• W2025122502 cites W1963557326 @default.
• W2025122502 cites W1967880683 @default.
• W2025122502 cites W1977467011 @default.
• W2025122502 cites W1980520251 @default.
• W2025122502 cites W1981496928 @default.
• W2025122502 cites W1981667569 @default.
• W2025122502 cites W1991680007 @default.
• W2025122502 cites W2000392923 @default.
• W2025122502 cites W2014340954 @default.
• W2025122502 cites W2020630430 @default.
• W2025122502 cites W2024464498 @default.
• W2025122502 cites W2042316019 @default.
• W2025122502 cites W2056685208 @default.
• W2025122502 cites W2083122376 @default.
• W2025122502 cites W2119615097 @default.
• W2025122502 cites W2122058106 @default.
• W2025122502 cites W2125751525 @default.
• W2025122502 cites W2130500105 @default.
• W2025122502 cites W2133643647 @default.
• W2025122502 cites W2138414621 @default.
• W2025122502 cites W2144488343 @default.
• W2025122502 cites W2149902033 @default.
• W2025122502 cites W2152353081 @default.
• W2025122502 cites W2161005330 @default.
• W2025122502 cites W2169453999 @default.
• W2025122502 doi "https://doi.org/10.1002/cncr.21977" @default.
• W2025122502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16752411" @default.
• W2025122502 hasPublicationYear "2006" @default.
• W2025122502 type Work @default.
• W2025122502 sameAs 2025122502 @default.
• W2025122502 citedByCount "40" @default.
• W2025122502 countsByYear W20251225022012 @default.
• W2025122502 countsByYear W20251225022013 @default.
• W2025122502 countsByYear W20251225022014 @default.
• W2025122502 countsByYear W20251225022015 @default.
• W2025122502 countsByYear W20251225022016 @default.
• W2025122502 countsByYear W20251225022017 @default.
• W2025122502 countsByYear W20251225022018 @default.
• W2025122502 countsByYear W20251225022019 @default.
• W2025122502 countsByYear W20251225022020 @default.
• W2025122502 countsByYear W20251225022021 @default.
• W2025122502 countsByYear W20251225022022 @default.
• W2025122502 crossrefType "journal-article" @default.
• W2025122502 hasAuthorship W2025122502A5005202372 @default.
• W2025122502 hasAuthorship W2025122502A5025415933 @default.
• W2025122502 hasAuthorship W2025122502A5036877791 @default.
• W2025122502 hasAuthorship W2025122502A5043757838 @default.
• W2025122502 hasAuthorship W2025122502A5078000437 @default.
• W2025122502 hasAuthorship W2025122502A5090286753 @default.
• W2025122502 hasConcept C104317684 @default.
• W2025122502 hasConcept C121608353 @default.
• W2025122502 hasConcept C126322002 @default.
• W2025122502 hasConcept C140752955 @default.
• W2025122502 hasConcept C143425029 @default.
• W2025122502 hasConcept C143998085 @default.
• W2025122502 hasConcept C150194340 @default.
• W2025122502 hasConcept C178169997 @default.
• W2025122502 hasConcept C190727270 @default.
• W2025122502 hasConcept C2780210213 @default.
• W2025122502 hasConcept C2781182431 @default.
• W2025122502 hasConcept C2909925829 @default.
• W2025122502 hasConcept C2992026798 @default.
• W2025122502 hasConcept C30481170 @default.
• W2025122502 hasConcept C33288867 @default.
• W2025122502 hasConcept C502942594 @default.
• W2025122502 hasConcept C54355233 @default.
• W2025122502 hasConcept C552990157 @default.
• W2025122502 hasConcept C555283112 @default.
• W2025122502 hasConcept C71924100 @default.
• W2025122502 hasConcept C86803240 @default.
• W2025122502 hasConceptScore W2025122502C104317684 @default.
• W2025122502 hasConceptScore W2025122502C121608353 @default.
• W2025122502 hasConceptScore W2025122502C126322002 @default.
• W2025122502 hasConceptScore W2025122502C140752955 @default.
• W2025122502 hasConceptScore W2025122502C143425029 @default.
• W2025122502 hasConceptScore W2025122502C143998085 @default.
• W2025122502 hasConceptScore W2025122502C150194340 @default.
• W2025122502 hasConceptScore W2025122502C178169997 @default.
• W2025122502 hasConceptScore W2025122502C190727270 @default.
• W2025122502 hasConceptScore W2025122502C2780210213 @default.
• W2025122502 hasConceptScore W2025122502C2781182431 @default.
• W2025122502 hasConceptScore W2025122502C2909925829 @default.
• W2025122502 hasConceptScore W2025122502C2992026798 @default.
• W2025122502 hasConceptScore W2025122502C30481170 @default.
• W2025122502 hasConceptScore W2025122502C33288867 @default.

• next