Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025127622> ?p ?o ?g. }
- W2025127622 endingPage "519" @default.
- W2025127622 startingPage "508" @default.
- W2025127622 abstract "Improved clinical management of prostate cancer has been impeded by an inadequate understanding of molecular genetic elements governing tumor progression. Gene signatures have provided improved prognostic indicators of human prostate cancer. The TGF-β/BMP-SMAD4 signaling pathway, which induces epithelial-mesenchymal transition (EMT), is known to constrain prostate cancer progression induced by Pten deletion. Herein, cyclin D1 inactivation reduced cellular proliferation in the murine prostate in vivo and in isogenic oncogene-transformed prostate cancer cell lines. The in vivo cyclin D1-mediated molecular signature predicted poor outcome of recurrence-free survival for patients with prostate cancer (K-means HR, 3.75, P = 0.02) and demonstrated that endogenous cyclin D1 restrains TGF-β, Snail, Twist, and Goosecoid signaling. Endogenous cyclin D1 enhanced Wnt and ES cell gene expression and expanded a prostate stem cell population. In chromatin immunoprecipitation sequencing, cyclin D1 occupied genes governing stem cell expansion and induced their transcription. The coordination of EMT restraining and stem cell expanding gene expression by cyclin D1 in the prostate may contribute to its strong prognostic value for poor outcome in biochemical-free recurrence in human prostate cancer." @default.
- W2025127622 created "2016-06-24" @default.
- W2025127622 creator A5006339979 @default.
- W2025127622 creator A5013077058 @default.
- W2025127622 creator A5015102287 @default.
- W2025127622 creator A5016235708 @default.
- W2025127622 creator A5016681558 @default.
- W2025127622 creator A5019711358 @default.
- W2025127622 creator A5027970904 @default.
- W2025127622 creator A5029197376 @default.
- W2025127622 creator A5041113795 @default.
- W2025127622 creator A5061299615 @default.
- W2025127622 creator A5071320926 @default.
- W2025127622 creator A5084188467 @default.
- W2025127622 creator A5089514530 @default.
- W2025127622 date "2014-01-15" @default.
- W2025127622 modified "2023-10-17" @default.
- W2025127622 title "Identification of a <i>Cyclin D1</i> Network in Prostate Cancer That Antagonizes Epithelial–Mesenchymal Restraint" @default.
- W2025127622 cites W1964081206 @default.
- W2025127622 cites W1964252337 @default.
- W2025127622 cites W1964636114 @default.
- W2025127622 cites W1971759686 @default.
- W2025127622 cites W1976811867 @default.
- W2025127622 cites W1982245135 @default.
- W2025127622 cites W1987647107 @default.
- W2025127622 cites W1996386813 @default.
- W2025127622 cites W2000786845 @default.
- W2025127622 cites W2003219632 @default.
- W2025127622 cites W2005722441 @default.
- W2025127622 cites W2012117840 @default.
- W2025127622 cites W2032580087 @default.
- W2025127622 cites W2040956277 @default.
- W2025127622 cites W2041643931 @default.
- W2025127622 cites W2048352529 @default.
- W2025127622 cites W2049700579 @default.
- W2025127622 cites W2066819549 @default.
- W2025127622 cites W2066957238 @default.
- W2025127622 cites W2069381736 @default.
- W2025127622 cites W2073759231 @default.
- W2025127622 cites W2080677621 @default.
- W2025127622 cites W2082297472 @default.
- W2025127622 cites W2091187698 @default.
- W2025127622 cites W2097141418 @default.
- W2025127622 cites W2100465174 @default.
- W2025127622 cites W2102870100 @default.
- W2025127622 cites W2107633226 @default.
- W2025127622 cites W2109069210 @default.
- W2025127622 cites W2109650221 @default.
- W2025127622 cites W2109998353 @default.
- W2025127622 cites W2120003927 @default.
- W2025127622 cites W2121948931 @default.
- W2025127622 cites W2123883227 @default.
- W2025127622 cites W2128360853 @default.
- W2025127622 cites W2129138172 @default.
- W2025127622 cites W2135854450 @default.
- W2025127622 cites W2139860222 @default.
- W2025127622 cites W2141091746 @default.
- W2025127622 cites W2147660153 @default.
- W2025127622 cites W2158734599 @default.
- W2025127622 cites W2163360413 @default.
- W2025127622 cites W2334338041 @default.
- W2025127622 cites W2408089991 @default.
- W2025127622 doi "https://doi.org/10.1158/0008-5472.can-13-1313" @default.
- W2025127622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3914674" @default.
- W2025127622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24282282" @default.
- W2025127622 hasPublicationYear "2014" @default.
- W2025127622 type Work @default.
- W2025127622 sameAs 2025127622 @default.
- W2025127622 citedByCount "41" @default.
- W2025127622 countsByYear W20251276222014 @default.
- W2025127622 countsByYear W20251276222015 @default.
- W2025127622 countsByYear W20251276222016 @default.
- W2025127622 countsByYear W20251276222017 @default.
- W2025127622 countsByYear W20251276222018 @default.
- W2025127622 countsByYear W20251276222019 @default.
- W2025127622 countsByYear W20251276222020 @default.
- W2025127622 countsByYear W20251276222021 @default.
- W2025127622 countsByYear W20251276222022 @default.
- W2025127622 countsByYear W20251276222023 @default.
- W2025127622 crossrefType "journal-article" @default.
- W2025127622 hasAuthorship W2025127622A5006339979 @default.
- W2025127622 hasAuthorship W2025127622A5013077058 @default.
- W2025127622 hasAuthorship W2025127622A5015102287 @default.
- W2025127622 hasAuthorship W2025127622A5016235708 @default.
- W2025127622 hasAuthorship W2025127622A5016681558 @default.
- W2025127622 hasAuthorship W2025127622A5019711358 @default.
- W2025127622 hasAuthorship W2025127622A5027970904 @default.
- W2025127622 hasAuthorship W2025127622A5029197376 @default.
- W2025127622 hasAuthorship W2025127622A5041113795 @default.
- W2025127622 hasAuthorship W2025127622A5061299615 @default.
- W2025127622 hasAuthorship W2025127622A5071320926 @default.
- W2025127622 hasAuthorship W2025127622A5084188467 @default.
- W2025127622 hasAuthorship W2025127622A5089514530 @default.
- W2025127622 hasBestOaLocation W20251276221 @default.
- W2025127622 hasConcept C11882975 @default.
- W2025127622 hasConcept C121608353 @default.
- W2025127622 hasConcept C137620995 @default.
- W2025127622 hasConcept C199835354 @default.