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• W2025128051 abstract "Background: EUS-FNA has been proven to be an accurate and safe technique to biopsy mediastinal lymphadenopathy/masses. However, the role of EUS-FNA to biopsy masses located in the lung parenchyma has not been assessed in prospective controlled studies. Aim: To prospectively assess the diagnostic yield and safety of EUS-FNA in lung parenchyma masses. Methods: Design: IRB approved. Prospective. Time of inclusion: 11/04-11/06. Inclusion Criteria: 1.) Patients (PT) with a lung mass in the parenchyma visible from the esophagus, that was not accesible for other type of biopsy, or with a prior negative biopsy by other means, in which a tissue diagnosis was required. Exclusion Criteria: 1.) PT refuses to participate in the study, 2.) Coagulopathy. EUS exam (conscious sedation with midazolam and petidine): GF-UCT160-OL5 Olympus® 5-7.5 MHz (processor EU-C60), 22 Gauge Cook needle. Statistical analysis: Descriptive analysis of results. Discrete variables (%). Continuous variables (mean + S.D.; median). Results: During the aforementioned period of time 21 consecutive PT meeting the inclusion and exclusion criteria were evaluated: M/F (76%/24%), age (64.0 + 12.5; 68). EUS-FNA (22 Gauge needle) was performed by using the standard technique; PT were under conscious sedation during biopsy, and were asked to hold the breath during EUS-FNA in an attempt to minimize the risks of pleural tear and pneumothorax due to FNA. Five cc of negative pressure was applied while 10 to and fro movements were performed within the lesion. Median number of passes: 1 (range 1-3). One of the 21 PT (5%) presented a benign mass in the lung (hamartoma) and 20 of 21 PT presented a malignant mass in the lung (20/21 = 95%; 95% CI: 79-100%); 14 of 20 malignant masses were a primary lung mass (14/20 = 70%; 95% CI: 46-88%) and 6 were metastatic to the lung (6/20 = 30%; 95% CI: 12-54%). EUS-FNA of lung masses (mass visible by EUS and amenable for FNA via transesophageal-transpleural route) obtained cells in all but one PT (20/21 = 95%; 95% CI: 79-100%). Sensitivity (18/20 = 90%; 95% CI: 68-99%), specificity (1/1 = 100%; 95% CI: 50-100%), accuracy (19/21 = 90%; 95% CI: 70-99%). Complications: one single PT developed a large pneumothorax in the first 24 hours after EUS-FNA, requiring chest tube placement (1/21 = 5%; 95% CI: 1-23%). No other complications were recorded. Conclusions: 1.) EUS-FNA appears to be an accurate and safe technique to achieve a tissue diagnosis in PT with a primary lung mass accessible for transesophageal-transpleural FNA. 2.) Superficial conscious sedation may be required to perform lung biopsies, as cooperation from the PT is required to minimize the risk for complications." @default.
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• W2025128051 date "2007-04-01" @default.
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• W2025128051 title "Endoscopic Ultrasound Guided Fine Needle Aspiration (EUS-FNA) of Masses Located in the Lung Parenchyma: Diagnostic Yield and Safety" @default.
• W2025128051 doi "https://doi.org/10.1016/j.gie.2007.03.073" @default.
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