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• W2025142014 abstract "The effects of a P 2 purinoceptor agonist, adenosine 5′‐O‐(2‐thiodiphosphate) (ADP‐β‐S) have been studied on insulin secretion and flow rate of the isolated perfused pancreas of the rat. In the presence of a moderately stimulating glucose concentration (8.3 m m ), ADP‐/7‐S (4.95–495 n m ) evoked a biphasic insulin response in a concentration‐dependent manner. A comparison of relative potency between ADP‐β‐S and adenosine 5′‐triphosphate (ATP) showed that ADP‐β‐S was 100 times more potent than ATP. On the other hand, in the presence of a non stimulatory glucose concentration (4.2 m m ), ADP‐β‐S (165 n m ) did not modify the basal insulin secretion. ADP‐β‐S, at concentrations effective on insulin secretion and also at higher concentrations (1.65 and 16.5 μ m ), provoked an increase of the pancreatic flow rate in a concentration‐dependent manner. Our results show that ADP‐β‐S is a potent insulin secretory P 2 purinoceptor agonist. As it is resistant to hydrolysis it might be useful in studying the effect of activation of the P 2 purinoceptor of β cells on insulin secretion in vivo ." @default.
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• W2025142014 date "1991-03-01" @default.
• W2025142014 modified "2023-10-18" @default.
• W2025142014 title "Adenosine-5′-O-(2-thiodiphosphate) is a potent agonist at P2 purinoceptors mediating insulin secretion from perfused rat pancreas" @default.
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• W2025142014 doi "https://doi.org/10.1111/j.1476-5381.1991.tb12223.x" @default.
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