FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025146800> ?p ?o ?g. }

• W2025146800 endingPage "877" @default.
• W2025146800 startingPage "864" @default.
• W2025146800 abstract "Colon-specific antigen-p is a tumor-associated antigen present in approximately 60% of colorectal cancers. Preclinical studies have shown that the murine monoclonal antibody Mu-9 has excellent tumor-targeting abilities; therefore, clinical studies were initiated.The immunoglobulin G and F(ab')2 were radiolabeled with 131I and administered to 13 and 12 patients, respectively, with advanced gastrointestinal cancer (colon, rectal, and pancreatic) for radioimmunodetection or radioimmunotherapy.Even in patients with highly elevated carcinoembryonic antigen levels, only one patient showed appreciable complexation of the labeled antibody, suggesting the epitope may not be highly expressed in the blood. Fifty percent of 131I-Mu-9 immunoglobulin G was cleared from the blood within 41 +/- 13 hours, while it took only 19 +/- 8 hours for the same amount of 131I-F(ab')2 to be cleared from the blood. Lesion detection in the abdomen, liver, and pelvis was greater than 90% for either the immunoglobulin G or F(ab')2. The dose absorbed by the normal organs, except the kidneys, was two- to threefold less for the F(ab')2 than for the whole immunoglobulin G. The dose to the kidneys was similar for both forms of immunoglobulin. The average tumor dose for 131I-Mu-9 immunoglobulin G was 13.9 +/- 11.0 cGy/mCi, and for 131I-F(ab')2 was 4.9 +/- 2.9. Tumor/red marrow dose ratios for the whole immunoglobulin G were 4.3 +/- 3.0, compared to 3.3 +/- 1.9 for the F(ab')2, suggesting the therapeutic window for the two forms of immunoglobulin may be similar. Eight of nine patients given the whole immunoglobulin G developed highly elevated levels of human anti-mouse antibody, whereas lower values were observed in five of seven patients given the F(ab')2.These initial results support the need for further evaluation of Mu-9 immunoglobulin G and F(ab')2 for targeting gastrointestinal cancer for radioimmunotherapy." @default.
• W2025146800 created "2016-06-24" @default.
• W2025146800 creator A5003890903 @default.
• W2025146800 creator A5031219007 @default.
• W2025146800 creator A5043569662 @default.
• W2025146800 creator A5046174892 @default.
• W2025146800 creator A5060417829 @default.
• W2025146800 creator A5066050468 @default.
• W2025146800 creator A5066656967 @default.
• W2025146800 creator A5069578510 @default.
• W2025146800 creator A5069993250 @default.
• W2025146800 creator A5077598659 @default.
• W2025146800 creator A5084632039 @default.
• W2025146800 creator A5088077447 @default.
• W2025146800 creator A5089767317 @default.
• W2025146800 date "1994-02-01" @default.
• W2025146800 modified "2023-10-18" @default.
• W2025146800 title "Phase I clinical evaluation of a new murine monoclonal antibody (mu-9) against colon-specific antigen-p for targeting gastrointestinal carcinomas" @default.
• W2025146800 cites W1855648752 @default.
• W2025146800 cites W1973029769 @default.
• W2025146800 cites W1974778911 @default.
• W2025146800 cites W1976098267 @default.
• W2025146800 cites W1987647839 @default.
• W2025146800 cites W2003010941 @default.
• W2025146800 cites W2011150674 @default.
• W2025146800 cites W2011603321 @default.
• W2025146800 cites W2036439324 @default.
• W2025146800 cites W2048674261 @default.
• W2025146800 cites W2062758337 @default.
• W2025146800 cites W2075725027 @default.
• W2025146800 cites W2087618299 @default.
• W2025146800 cites W4302031722 @default.
• W2025146800 doi "https://doi.org/10.1002/1097-0142(19940201)73:3+<864::aid-cncr2820731318>3.0.co;2-9" @default.
• W2025146800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8306272" @default.
• W2025146800 hasPublicationYear "1994" @default.
• W2025146800 type Work @default.
• W2025146800 sameAs 2025146800 @default.
• W2025146800 citedByCount "18" @default.
• W2025146800 countsByYear W20251468002012 @default.
• W2025146800 countsByYear W20251468002016 @default.
• W2025146800 crossrefType "journal-article" @default.
• W2025146800 hasAuthorship W2025146800A5003890903 @default.
• W2025146800 hasAuthorship W2025146800A5031219007 @default.
• W2025146800 hasAuthorship W2025146800A5043569662 @default.
• W2025146800 hasAuthorship W2025146800A5046174892 @default.
• W2025146800 hasAuthorship W2025146800A5060417829 @default.
• W2025146800 hasAuthorship W2025146800A5066050468 @default.
• W2025146800 hasAuthorship W2025146800A5066656967 @default.
• W2025146800 hasAuthorship W2025146800A5069578510 @default.
• W2025146800 hasAuthorship W2025146800A5069993250 @default.
• W2025146800 hasAuthorship W2025146800A5077598659 @default.
• W2025146800 hasAuthorship W2025146800A5084632039 @default.
• W2025146800 hasAuthorship W2025146800A5088077447 @default.
• W2025146800 hasAuthorship W2025146800A5089767317 @default.
• W2025146800 hasConcept C121608353 @default.
• W2025146800 hasConcept C126322002 @default.
• W2025146800 hasConcept C142724271 @default.
• W2025146800 hasConcept C147483822 @default.
• W2025146800 hasConcept C159654299 @default.
• W2025146800 hasConcept C203014093 @default.
• W2025146800 hasConcept C2776146153 @default.
• W2025146800 hasConcept C2777064799 @default.
• W2025146800 hasConcept C2777387746 @default.
• W2025146800 hasConcept C2780898057 @default.
• W2025146800 hasConcept C526805850 @default.
• W2025146800 hasConcept C542804219 @default.
• W2025146800 hasConcept C542903549 @default.
• W2025146800 hasConcept C71924100 @default.
• W2025146800 hasConcept C90924648 @default.
• W2025146800 hasConceptScore W2025146800C121608353 @default.
• W2025146800 hasConceptScore W2025146800C126322002 @default.
• W2025146800 hasConceptScore W2025146800C142724271 @default.
• W2025146800 hasConceptScore W2025146800C147483822 @default.
• W2025146800 hasConceptScore W2025146800C159654299 @default.
• W2025146800 hasConceptScore W2025146800C203014093 @default.
• W2025146800 hasConceptScore W2025146800C2776146153 @default.
• W2025146800 hasConceptScore W2025146800C2777064799 @default.
• W2025146800 hasConceptScore W2025146800C2777387746 @default.
• W2025146800 hasConceptScore W2025146800C2780898057 @default.
• W2025146800 hasConceptScore W2025146800C526805850 @default.
• W2025146800 hasConceptScore W2025146800C542804219 @default.
• W2025146800 hasConceptScore W2025146800C542903549 @default.
• W2025146800 hasConceptScore W2025146800C71924100 @default.
• W2025146800 hasConceptScore W2025146800C90924648 @default.
• W2025146800 hasIssue "S3" @default.
• W2025146800 hasLocation W20251468001 @default.
• W2025146800 hasLocation W20251468002 @default.
• W2025146800 hasOpenAccess W2025146800 @default.
• W2025146800 hasPrimaryLocation W20251468001 @default.
• W2025146800 hasRelatedWork W119500569 @default.
• W2025146800 hasRelatedWork W1587862264 @default.
• W2025146800 hasRelatedWork W1599748558 @default.
• W2025146800 hasRelatedWork W1985628011 @default.
• W2025146800 hasRelatedWork W1997716688 @default.
• W2025146800 hasRelatedWork W2025146800 @default.
• W2025146800 hasRelatedWork W2027565419 @default.
• W2025146800 hasRelatedWork W2156516324 @default.
• W2025146800 hasRelatedWork W2262061163 @default.

• next