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• W2025147560 startingPage "4293" @default.
• W2025147560 abstract "The triazole analogs were obtained via. multistep synthesis sequence beginning with ethyl nicotinoate 3 which on treatment with hydrazine hydrate yields nicotinoyl hydrazide 4 . Intermolecular cyclisation of 4 with 4-methylbenzoic acid in presence of phosphorous oxy chloride affords 2-(3-pyridyl)-5-(4-methylphenyl)-1,3,4-oxadiazole 5 . Condensation of 5 with various substituted 2-hydrazino benzothiazole 2a – j results in 3-(3-pyridyl)-5-(4-methylphenyl)-4-( N -substituted-1,3-benzothiazol-2-amino)-4 H -1,2,4-triazole 6a – j analogs. All the compounds have been characterized by elemental analysis, IR, 1 H NMR, 13 C NMR and mass spectral data. In vitro antitubercular activity was carried out against Mycobacterium tuberculosis H 37 Rv strain using Lowenstein-Jensen medium and antimicrobial activity against various bacteria and fungi using broth microdilution method. Compounds 2e , 6a , 6b , 6c , 6d , 6g , 6h and 6i emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antituberculars. Compound 6j showed better antitubercular activity compared to rifampicin. 3-(3-Pyridyl)-5-(4-methylphenyl)-4-( N -substituted-1,3-benzothiazol-2-amino)-4 H -1,2,4-triazole 6a – j were synthesized and their antitubercular activity against H 37 Rv and antimicrobial activities have been tested." @default.
• W2025147560 created "2016-06-24" @default.
• W2025147560 creator A5005642993 @default.
• W2025147560 creator A5064002081 @default.
• W2025147560 creator A5059983540 @default.
• W2025147560 date "2010-09-01" @default.
• W2025147560 modified "2023-09-24" @default.
• W2025147560 title "Pharmacological evaluation and characterizations of newly synthesized 1,2,4-triazoles" @default.
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• W2025147560 doi "https://doi.org/10.1016/j.ejmech.2010.06.031" @default.
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