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• W2025148930 endingPage "330" @default.
• W2025148930 startingPage "323" @default.
• W2025148930 abstract "Virulent strains of bacteria and viruses recognize host cells by their plasma membrane receptors and often exploit the native translocation machinery to invade the cell. A promising therapeutic concept for early interruption of pathogen infection is to subvert this pathogenic trickery using exogenously introduced decoys that present high-affinity mimics of cellular receptors. This review highlights emerging applications of molecularly engineered lipid-bilayer-based nanostructures, namely (i) functionalized liposomes, (ii) supported colloidal bilayers or protocells and (iii) reconstituted lipoproteins, which display functional cellular receptors in optimized conformational and aggregative states. These decoys outcompete host cell receptors by preferentially binding to and neutralizing virulence factors of both bacteria and viruses, thereby promising a new approach to antipathogenic therapy. Virulent strains of bacteria and viruses recognize host cells by their plasma membrane receptors and often exploit the native translocation machinery to invade the cell. A promising therapeutic concept for early interruption of pathogen infection is to subvert this pathogenic trickery using exogenously introduced decoys that present high-affinity mimics of cellular receptors. This review highlights emerging applications of molecularly engineered lipid-bilayer-based nanostructures, namely (i) functionalized liposomes, (ii) supported colloidal bilayers or protocells and (iii) reconstituted lipoproteins, which display functional cellular receptors in optimized conformational and aggregative states. These decoys outcompete host cell receptors by preferentially binding to and neutralizing virulence factors of both bacteria and viruses, thereby promising a new approach to antipathogenic therapy. any living organism in which a parasite resides and reproduces. lipid nanoparticle supported by an apolipoprotein scaffold that is capable of incorporating functional proteins and lipids. microbe that is capable of causing disease in an animal host, such as a bacterium or virus. artificial cell-like microparticle designed to mimic cellular functions. molecule expressed by a pathogen that facilitates invasion of a host or evasion of host defenses." @default.
• W2025148930 created "2016-06-24" @default.
• W2025148930 creator A5019869780 @default.
• W2025148930 creator A5082421427 @default.
• W2025148930 creator A5082957650 @default.
• W2025148930 date "2012-06-01" @default.
• W2025148930 modified "2023-09-30" @default.
• W2025148930 title "Inhibiting host–pathogen interactions using membrane-based nanostructures" @default.
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• W2025148930 doi "https://doi.org/10.1016/j.tibtech.2012.03.002" @default.
• W2025148930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22464596" @default.
• W2025148930 hasPublicationYear "2012" @default.
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