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• W2025154625 abstract "The syntheses and antimitotic activity of several novel 18a-homo-analogs of 2-methoxyestradiol are described. Structural modifications of the parent 2-methoxy-18a-homoestradiol include introduction of unsaturation in the D-ring and methylation of the 17-OH. Of seven analogs synthesized, one has demonstrated superior biological activities compared to 2-methoxyestradiol. The relationship between biological activity and the conformational preference of the 13-ethyl group as determined by computational analysis is discussed." @default.
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• W2025154625 date "2008-02-01" @default.
• W2025154625 modified "2023-09-26" @default.
• W2025154625 title "Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs—Part II" @default.
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• W2025154625 doi "https://doi.org/10.1016/j.steroids.2007.11.003" @default.
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