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- W2025155936 abstract "The difficulty of establishing structure-activity relationships in the β-lactam family of antibiotics stems from the fact that: (1) The targets in various bacteria exhibit widely different sensitivities. (2) Some bacteria produce β-lactamases, enzymes capable of destroying the antibiotics. The rates of the reactions with the β-lactamases and the target enzymes are not necessarily related. (3) In Gram- negative bacteria, the diffusion rate through the outer membrane varies independently from the two other factors." @default.
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- W2025155936 date "1988-01-01" @default.
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- W2025155936 title "Structure-activity relationships in the β- lactam family: an impossible dream" @default.
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- W2025155936 doi "https://doi.org/10.1016/0006-2952(88)90764-2" @default.
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