Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025161273> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2025161273 endingPage "49" @default.
- W2025161273 startingPage "43" @default.
- W2025161273 abstract "Efficient repair of DNA double strand breaks is essential for cells to avoid increased mutation rates, genomic instability, and even cell death. Consequently, cells have evolved multiple mechanisms for rapidly repairing these DNA lesions, including error-free homologous recombination as well as error-prone pathways such as nonhomologous end-joining. What happens to DSBs that are repaired inefficiently or not at all? Recently, several studies in budding yeast have shown that these more recalcitrant DSBs are localized to the nuclear periphery through interactions between the nuclear envelope protein, Mps3, and proteins associated with DSB chromatin. Why these DSBs are tethered to the nuclear periphery is still not clear, though the current view is that alternative repair pathways may be activated at the periphery in a final attempt to repair the lesion. In this Extra-view, we discuss these recent reports, and we show that the Est1 component of the telomerase machinery plays an essential role in anchoring DSB chromatin to the nuclear envelope protein, Mps3." @default.
- W2025161273 created "2016-06-24" @default.
- W2025161273 creator A5035490948 @default.
- W2025161273 creator A5037369193 @default.
- W2025161273 date "2010-01-01" @default.
- W2025161273 modified "2023-10-04" @default.
- W2025161273 title "Opening the DNA repair toolbox: Localization of DNA double strand breaks to the nuclear periphery" @default.
- W2025161273 cites W1514461091 @default.
- W2025161273 cites W1606954381 @default.
- W2025161273 cites W1970225082 @default.
- W2025161273 cites W2017782528 @default.
- W2025161273 cites W2042499074 @default.
- W2025161273 cites W2043527294 @default.
- W2025161273 cites W2076170552 @default.
- W2025161273 cites W2096630319 @default.
- W2025161273 cites W2110819297 @default.
- W2025161273 cites W2124037827 @default.
- W2025161273 doi "https://doi.org/10.4161/cc.9.1.10317" @default.
- W2025161273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20016273" @default.
- W2025161273 hasPublicationYear "2010" @default.
- W2025161273 type Work @default.
- W2025161273 sameAs 2025161273 @default.
- W2025161273 citedByCount "29" @default.
- W2025161273 countsByYear W20251612732012 @default.
- W2025161273 countsByYear W20251612732013 @default.
- W2025161273 countsByYear W20251612732014 @default.
- W2025161273 countsByYear W20251612732015 @default.
- W2025161273 countsByYear W20251612732016 @default.
- W2025161273 countsByYear W20251612732017 @default.
- W2025161273 countsByYear W20251612732019 @default.
- W2025161273 countsByYear W20251612732021 @default.
- W2025161273 crossrefType "journal-article" @default.
- W2025161273 hasAuthorship W2025161273A5035490948 @default.
- W2025161273 hasAuthorship W2025161273A5037369193 @default.
- W2025161273 hasBestOaLocation W20251612731 @default.
- W2025161273 hasConcept C102744134 @default.
- W2025161273 hasConcept C134935766 @default.
- W2025161273 hasConcept C143425029 @default.
- W2025161273 hasConcept C178169997 @default.
- W2025161273 hasConcept C2779012473 @default.
- W2025161273 hasConcept C2992406208 @default.
- W2025161273 hasConcept C54355233 @default.
- W2025161273 hasConcept C552990157 @default.
- W2025161273 hasConcept C83640560 @default.
- W2025161273 hasConcept C86803240 @default.
- W2025161273 hasConcept C95444343 @default.
- W2025161273 hasConceptScore W2025161273C102744134 @default.
- W2025161273 hasConceptScore W2025161273C134935766 @default.
- W2025161273 hasConceptScore W2025161273C143425029 @default.
- W2025161273 hasConceptScore W2025161273C178169997 @default.
- W2025161273 hasConceptScore W2025161273C2779012473 @default.
- W2025161273 hasConceptScore W2025161273C2992406208 @default.
- W2025161273 hasConceptScore W2025161273C54355233 @default.
- W2025161273 hasConceptScore W2025161273C552990157 @default.
- W2025161273 hasConceptScore W2025161273C83640560 @default.
- W2025161273 hasConceptScore W2025161273C86803240 @default.
- W2025161273 hasConceptScore W2025161273C95444343 @default.
- W2025161273 hasIssue "1" @default.
- W2025161273 hasLocation W20251612731 @default.
- W2025161273 hasLocation W20251612732 @default.
- W2025161273 hasOpenAccess W2025161273 @default.
- W2025161273 hasPrimaryLocation W20251612731 @default.
- W2025161273 hasRelatedWork W1886260756 @default.
- W2025161273 hasRelatedWork W1975859337 @default.
- W2025161273 hasRelatedWork W2017423489 @default.
- W2025161273 hasRelatedWork W2026518361 @default.
- W2025161273 hasRelatedWork W2549803564 @default.
- W2025161273 hasRelatedWork W2588238986 @default.
- W2025161273 hasRelatedWork W2735460642 @default.
- W2025161273 hasRelatedWork W2765869464 @default.
- W2025161273 hasRelatedWork W2785715185 @default.
- W2025161273 hasRelatedWork W2982185309 @default.
- W2025161273 hasVolume "9" @default.
- W2025161273 isParatext "false" @default.
- W2025161273 isRetracted "false" @default.
- W2025161273 magId "2025161273" @default.
- W2025161273 workType "article" @default.