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- W2025162012 abstract "Abstract Foetal development and infancy are life stages that are characterised by rapid growth, development and maturation of organs and systems. Variation in the quality or quantity of nutrients consumed by mothers during pregnancy, or infants during the first year of life, can exert permanent and powerful effects upon developing tissues. These effects are termed ‘programming’ and represent an important risk factor for noncommunicable diseases of adulthood, including the metabolic syndrome and coronary heart disease. This narrative review provides an overview of the evidence‐base showing that indicators of nutritional deficit in pregnancy are associated with a greater risk of type‐2 diabetes and cardiovascular mortality. There is also a limited evidence‐base that suggests some relationship between breastfeeding and the timing and type of foods used in weaning, and disease in later life. Many of the associations reported between indicators of early growth and adult disease appear to interact with specific genotypes. This supports the idea that programming is one of several cumulative influences upon health and disease acting across the lifespan. Experimental studies have provided important clues to the mechanisms that link nutritional challenges in early life to disease in adulthood. It is suggested that nutritional programming is a product of the altered expression of genes that regulate the cell cycle, resulting in effective remodelling of tissue structure and functionality. The observation that traits programmed by nutritional exposures in foetal life can be transmitted to further generations adds weight the argument that heritable epigenetic modifications play a critical role in nutritional programming." @default.
- W2025162012 created "2016-06-24" @default.
- W2025162012 creator A5076640186 @default.
- W2025162012 date "2014-01-31" @default.
- W2025162012 modified "2023-10-09" @default.
- W2025162012 title "Nutrition in early life and the programming of adult disease: a review" @default.
- W2025162012 cites W1496227568 @default.
- W2025162012 cites W1526516695 @default.
- W2025162012 cites W1904623078 @default.
- W2025162012 cites W1961748990 @default.
- W2025162012 cites W1963649010 @default.
- W2025162012 cites W1963993140 @default.
- W2025162012 cites W1964858469 @default.
- W2025162012 cites W1966165909 @default.
- W2025162012 cites W1967064280 @default.
- W2025162012 cites W1969345916 @default.
- W2025162012 cites W1970797041 @default.
- W2025162012 cites W1980045712 @default.
- W2025162012 cites W1984423810 @default.
- W2025162012 cites W1984707167 @default.
- W2025162012 cites W1986667734 @default.
- W2025162012 cites W1988429695 @default.
- W2025162012 cites W1988730579 @default.
- W2025162012 cites W1990916340 @default.
- W2025162012 cites W1991148887 @default.
- W2025162012 cites W1991187107 @default.
- W2025162012 cites W1995847153 @default.
- W2025162012 cites W1997435091 @default.
- W2025162012 cites W1998970086 @default.
- W2025162012 cites W1999084420 @default.
- W2025162012 cites W2000384791 @default.
- W2025162012 cites W2002304855 @default.
- W2025162012 cites W2004372662 @default.
- W2025162012 cites W2008332279 @default.
- W2025162012 cites W2010373585 @default.
- W2025162012 cites W2010636931 @default.
- W2025162012 cites W2015838103 @default.
- W2025162012 cites W2017507345 @default.
- W2025162012 cites W2020089910 @default.
- W2025162012 cites W2020596859 @default.
- W2025162012 cites W2022816137 @default.
- W2025162012 cites W2024672438 @default.
- W2025162012 cites W2027426804 @default.
- W2025162012 cites W2031792984 @default.
- W2025162012 cites W2032979351 @default.
- W2025162012 cites W2033167203 @default.
- W2025162012 cites W2035616843 @default.
- W2025162012 cites W2036785198 @default.
- W2025162012 cites W2038170239 @default.
- W2025162012 cites W2038438919 @default.
- W2025162012 cites W2038479789 @default.
- W2025162012 cites W2044425311 @default.
- W2025162012 cites W2047058277 @default.
- W2025162012 cites W2050423048 @default.
- W2025162012 cites W2052686784 @default.
- W2025162012 cites W2055228751 @default.
- W2025162012 cites W2058472065 @default.
- W2025162012 cites W2067403629 @default.
- W2025162012 cites W2069074157 @default.
- W2025162012 cites W2072390372 @default.
- W2025162012 cites W2073804633 @default.
- W2025162012 cites W2073974662 @default.
- W2025162012 cites W2075569196 @default.
- W2025162012 cites W2076627334 @default.
- W2025162012 cites W2079026961 @default.
- W2025162012 cites W2081974975 @default.
- W2025162012 cites W2082948887 @default.
- W2025162012 cites W2083321610 @default.
- W2025162012 cites W2084042327 @default.
- W2025162012 cites W2087753447 @default.
- W2025162012 cites W2088346988 @default.
- W2025162012 cites W2091598977 @default.
- W2025162012 cites W2093559962 @default.
- W2025162012 cites W2094340656 @default.
- W2025162012 cites W2095974470 @default.
- W2025162012 cites W2096513555 @default.
- W2025162012 cites W2098545566 @default.
- W2025162012 cites W2099162576 @default.
- W2025162012 cites W2099446502 @default.
- W2025162012 cites W2099680351 @default.
- W2025162012 cites W2100185175 @default.
- W2025162012 cites W2105686571 @default.
- W2025162012 cites W2111793219 @default.
- W2025162012 cites W2115116599 @default.
- W2025162012 cites W2118429083 @default.
- W2025162012 cites W2119320729 @default.
- W2025162012 cites W2121604444 @default.
- W2025162012 cites W2121917420 @default.
- W2025162012 cites W2121960810 @default.
- W2025162012 cites W2122540809 @default.
- W2025162012 cites W2123761577 @default.
- W2025162012 cites W2124699909 @default.
- W2025162012 cites W2125089843 @default.
- W2025162012 cites W2127407472 @default.
- W2025162012 cites W2130583716 @default.
- W2025162012 cites W2131118272 @default.
- W2025162012 cites W2132199299 @default.
- W2025162012 cites W2132853116 @default.