FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025173764> ?p ?o ?g. }

• W2025173764 endingPage "4663" @default.
• W2025173764 startingPage "4657" @default.
• W2025173764 abstract "Gram-negative bacterial proteins secreted by ABC exporters carry a secretion signal in their carboxylic extremities. This characteristic suggests that the polypeptide needs to be fully synthesized before it can be secreted and, therefore, presumably may fold at least in part before its secretion. We investigated the relationship between folding and secretion using HasA, a hemoprotein of Serratia marcescens secreted into the extracellular medium by a dedicated Has ABC exporter. We first demonstrated that when HasA is sequestered in the cytoplasm it can acquire its tertiary structure, as assessed from its capacity to bind heme. The cytoplasmic pool of HasA cannot be secreted and inhibits the secretion of newly synthesized molecules. HasA folding in the cytoplasm was independent of either its capacity to bind heme or the presence of SecB, although SecB is essential for HasA secretion. Our findings indicate a strong coupling between synthesis and secretion in the type I secretion pathway." @default.
• W2025173764 created "2016-06-24" @default.
• W2025173764 creator A5060888680 @default.
• W2025173764 creator A5070531752 @default.
• W2025173764 date "2001-09-03" @default.
• W2025173764 modified "2023-10-03" @default.
• W2025173764 title "Folded HasA inhibits its own secretion through its ABC exporter" @default.
• W2025173764 cites W1539645325 @default.
• W2025173764 cites W1565821928 @default.
• W2025173764 cites W1566515137 @default.
• W2025173764 cites W1569943050 @default.
• W2025173764 cites W1582760489 @default.
• W2025173764 cites W1892148740 @default.
• W2025173764 cites W1968685804 @default.
• W2025173764 cites W1969742839 @default.
• W2025173764 cites W1978464273 @default.
• W2025173764 cites W1986663500 @default.
• W2025173764 cites W1988284346 @default.
• W2025173764 cites W1990996770 @default.
• W2025173764 cites W1992014529 @default.
• W2025173764 cites W1993213855 @default.
• W2025173764 cites W2001586974 @default.
• W2025173764 cites W2007245883 @default.
• W2025173764 cites W2013031563 @default.
• W2025173764 cites W2017765211 @default.
• W2025173764 cites W2020961473 @default.
• W2025173764 cites W2026182346 @default.
• W2025173764 cites W2034774551 @default.
• W2025173764 cites W2043141069 @default.
• W2025173764 cites W2061126505 @default.
• W2025173764 cites W2063897171 @default.
• W2025173764 cites W2078846038 @default.
• W2025173764 cites W2084231685 @default.
• W2025173764 cites W2085173147 @default.
• W2025173764 cites W2096520812 @default.
• W2025173764 cites W2108575112 @default.
• W2025173764 cites W2110386424 @default.
• W2025173764 cites W2160084442 @default.
• W2025173764 cites W2163005034 @default.
• W2025173764 cites W2165732172 @default.
• W2025173764 cites W258549815 @default.
• W2025173764 cites W79381975 @default.
• W2025173764 doi "https://doi.org/10.1093/emboj/20.17.4657" @default.
• W2025173764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/125584" @default.
• W2025173764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11532930" @default.
• W2025173764 hasPublicationYear "2001" @default.
• W2025173764 type Work @default.
• W2025173764 sameAs 2025173764 @default.
• W2025173764 citedByCount "53" @default.
• W2025173764 countsByYear W20251737642012 @default.
• W2025173764 countsByYear W20251737642013 @default.
• W2025173764 countsByYear W20251737642014 @default.
• W2025173764 countsByYear W20251737642015 @default.
• W2025173764 countsByYear W20251737642016 @default.
• W2025173764 countsByYear W20251737642017 @default.
• W2025173764 countsByYear W20251737642018 @default.
• W2025173764 countsByYear W20251737642019 @default.
• W2025173764 countsByYear W20251737642020 @default.
• W2025173764 countsByYear W20251737642021 @default.
• W2025173764 countsByYear W20251737642023 @default.
• W2025173764 crossrefType "journal-article" @default.
• W2025173764 hasAuthorship W2025173764A5060888680 @default.
• W2025173764 hasAuthorship W2025173764A5070531752 @default.
• W2025173764 hasBestOaLocation W20251737642 @default.
• W2025173764 hasConcept C104317684 @default.
• W2025173764 hasConcept C10858879 @default.
• W2025173764 hasConcept C156399914 @default.
• W2025173764 hasConcept C167625842 @default.
• W2025173764 hasConcept C181199279 @default.
• W2025173764 hasConcept C190062978 @default.
• W2025173764 hasConcept C2776217839 @default.
• W2025173764 hasConcept C2776309202 @default.
• W2025173764 hasConcept C28406088 @default.
• W2025173764 hasConcept C49039625 @default.
• W2025173764 hasConcept C547475151 @default.
• W2025173764 hasConcept C55493867 @default.
• W2025173764 hasConcept C86803240 @default.
• W2025173764 hasConcept C95444343 @default.
• W2025173764 hasConceptScore W2025173764C104317684 @default.
• W2025173764 hasConceptScore W2025173764C10858879 @default.
• W2025173764 hasConceptScore W2025173764C156399914 @default.
• W2025173764 hasConceptScore W2025173764C167625842 @default.
• W2025173764 hasConceptScore W2025173764C181199279 @default.
• W2025173764 hasConceptScore W2025173764C190062978 @default.
• W2025173764 hasConceptScore W2025173764C2776217839 @default.
• W2025173764 hasConceptScore W2025173764C2776309202 @default.
• W2025173764 hasConceptScore W2025173764C28406088 @default.
• W2025173764 hasConceptScore W2025173764C49039625 @default.
• W2025173764 hasConceptScore W2025173764C547475151 @default.
• W2025173764 hasConceptScore W2025173764C55493867 @default.
• W2025173764 hasConceptScore W2025173764C86803240 @default.
• W2025173764 hasConceptScore W2025173764C95444343 @default.
• W2025173764 hasIssue "17" @default.
• W2025173764 hasLocation W20251737641 @default.
• W2025173764 hasLocation W20251737642 @default.
• W2025173764 hasLocation W20251737643 @default.
• W2025173764 hasLocation W20251737644 @default.
• W2025173764 hasOpenAccess W2025173764 @default.

• next