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- W2025183556 abstract "Background In Saccharomyces cerevisiae and other organisms, the UBC9 (ubiquitin-conjugating 9) protein modifies the function of many different target proteins through covalent attachment of the ubiquitin-like protein SMT-3/SUMO. Results Using a second-site suppression screen of a mutation in the nod locus with a variable meiotic phenotype, we have identified mutations in the Drosophila melanogaster UBC9 homologue, encoded by the gene lesswright (lwr). lwr mutations dominantly suppress the nondisjunction and cytological defects of female meiotic mutations that affect spindle formation. The lwr lethal phenotype is rescued by a Drosophila UBC9/lwr transgene. Conclusions We suggest that LWR mediates the dissociation of heterochromatic regions of homologues at the end of meiotic prophase I. Our model proposes that when there is less LWR protein, homologues remain together longer, allowing for more normal spindle formation in mutant backgrounds and therefore more accurate meiotic chromosome segregation." @default.
- W2025183556 created "2016-06-24" @default.
- W2025183556 creator A5035025086 @default.
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- W2025183556 creator A5070769944 @default.
- W2025183556 creator A5082018071 @default.
- W2025183556 date "2001-03-01" @default.
- W2025183556 modified "2023-10-07" @default.
- W2025183556 title "The<i>Drosophila</i>UBC9 homologue<i>lesswright</i>mediates the disjunction of homologues in meiosis I" @default.
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- W2025183556 doi "https://doi.org/10.1046/j.1365-2443.2001.00413.x" @default.
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