Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025183648> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2025183648 endingPage "529" @default.
- W2025183648 startingPage "524" @default.
- W2025183648 abstract "This study was designed to assess the pharmacokinetics (PK) and safety of fimasartan, an angiotensin II type 1 receptor blocker, in hepatic impairment patients as compared with healthy subjects. An open-label, single-dose, parallel study was conducted in 6 healthy male volunteers and 12 subjects with hepatic impairment. Healthy subjects were matched with hepatic dysfunction patients on the basis of age, gender, and body weight. After a single 120-mg oral administration of fimasartan, PK parameters and safety were analyzed between the hepatic dysfunction groups and healthy group. Compared with the healthy subjects, the geometric mean ratio and 90% confidence intervals for the maximum plasma concentration and the mean area under the plasma concentration–time curve from 0 to infinity (AUC)inf were 0.77 (0.24–2.47) and 1.11 (0.50–2.46), respectively, for the mild hepatic impairment and 6.55 (3.56–12.03) and 5.17 (4.19–6.37), respectively, for moderate hepatic impairment. However, there was no significant difference in time to peak plasma concentration (tmax) and elimination half-life, and there were no serious or severe adverse events in all subjects. Subjects with mild hepatic impairment exhibited similar bioavailability compared with healthy subjects, whereas subjects with moderate hepatic impairment seemed to exhibit a higher level of systemic exposure to fimasartan than healthy subjects. In addition, all subjects were tolerable with fimasartan." @default.
- W2025183648 created "2016-06-24" @default.
- W2025183648 creator A5006412769 @default.
- W2025183648 creator A5022690482 @default.
- W2025183648 creator A5048686703 @default.
- W2025183648 creator A5054417741 @default.
- W2025183648 creator A5072521978 @default.
- W2025183648 creator A5075482380 @default.
- W2025183648 creator A5082949208 @default.
- W2025183648 creator A5085332322 @default.
- W2025183648 creator A5090411311 @default.
- W2025183648 creator A5091575980 @default.
- W2025183648 date "2013-12-01" @default.
- W2025183648 modified "2023-10-06" @default.
- W2025183648 title "Influence of Hepatic Dysfunction on the Pharmacokinetics and Safety of Fimasartan" @default.
- W2025183648 cites W1682825855 @default.
- W2025183648 cites W1973605558 @default.
- W2025183648 cites W1978977357 @default.
- W2025183648 cites W1982002364 @default.
- W2025183648 cites W1994912901 @default.
- W2025183648 cites W2002121467 @default.
- W2025183648 cites W2018059421 @default.
- W2025183648 cites W2019532583 @default.
- W2025183648 cites W2020371789 @default.
- W2025183648 cites W2028821776 @default.
- W2025183648 cites W2047908520 @default.
- W2025183648 cites W2068647218 @default.
- W2025183648 cites W2075320053 @default.
- W2025183648 cites W2076385318 @default.
- W2025183648 cites W2077796674 @default.
- W2025183648 cites W2091720550 @default.
- W2025183648 cites W2125457175 @default.
- W2025183648 cites W2148760504 @default.
- W2025183648 cites W2156121263 @default.
- W2025183648 cites W4211124708 @default.
- W2025183648 cites W1985258248 @default.
- W2025183648 doi "https://doi.org/10.1097/fjc.0000000000000010" @default.
- W2025183648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24084213" @default.
- W2025183648 hasPublicationYear "2013" @default.
- W2025183648 type Work @default.
- W2025183648 sameAs 2025183648 @default.
- W2025183648 citedByCount "8" @default.
- W2025183648 countsByYear W20251836482015 @default.
- W2025183648 countsByYear W20251836482016 @default.
- W2025183648 countsByYear W20251836482017 @default.
- W2025183648 countsByYear W20251836482018 @default.
- W2025183648 countsByYear W20251836482022 @default.
- W2025183648 crossrefType "journal-article" @default.
- W2025183648 hasAuthorship W2025183648A5006412769 @default.
- W2025183648 hasAuthorship W2025183648A5022690482 @default.
- W2025183648 hasAuthorship W2025183648A5048686703 @default.
- W2025183648 hasAuthorship W2025183648A5054417741 @default.
- W2025183648 hasAuthorship W2025183648A5072521978 @default.
- W2025183648 hasAuthorship W2025183648A5075482380 @default.
- W2025183648 hasAuthorship W2025183648A5082949208 @default.
- W2025183648 hasAuthorship W2025183648A5085332322 @default.
- W2025183648 hasAuthorship W2025183648A5090411311 @default.
- W2025183648 hasAuthorship W2025183648A5091575980 @default.
- W2025183648 hasConcept C112705442 @default.
- W2025183648 hasConcept C126322002 @default.
- W2025183648 hasConcept C181389837 @default.
- W2025183648 hasConcept C197934379 @default.
- W2025183648 hasConcept C2908939727 @default.
- W2025183648 hasConcept C44249647 @default.
- W2025183648 hasConcept C71924100 @default.
- W2025183648 hasConcept C90924648 @default.
- W2025183648 hasConcept C98274493 @default.
- W2025183648 hasConceptScore W2025183648C112705442 @default.
- W2025183648 hasConceptScore W2025183648C126322002 @default.
- W2025183648 hasConceptScore W2025183648C181389837 @default.
- W2025183648 hasConceptScore W2025183648C197934379 @default.
- W2025183648 hasConceptScore W2025183648C2908939727 @default.
- W2025183648 hasConceptScore W2025183648C44249647 @default.
- W2025183648 hasConceptScore W2025183648C71924100 @default.
- W2025183648 hasConceptScore W2025183648C90924648 @default.
- W2025183648 hasConceptScore W2025183648C98274493 @default.
- W2025183648 hasIssue "6" @default.
- W2025183648 hasLocation W20251836481 @default.
- W2025183648 hasLocation W20251836482 @default.
- W2025183648 hasOpenAccess W2025183648 @default.
- W2025183648 hasPrimaryLocation W20251836481 @default.
- W2025183648 hasRelatedWork W1505739641 @default.
- W2025183648 hasRelatedWork W16113689 @default.
- W2025183648 hasRelatedWork W2027491976 @default.
- W2025183648 hasRelatedWork W2044251933 @default.
- W2025183648 hasRelatedWork W2046280088 @default.
- W2025183648 hasRelatedWork W2073177056 @default.
- W2025183648 hasRelatedWork W2099575842 @default.
- W2025183648 hasRelatedWork W2110192055 @default.
- W2025183648 hasRelatedWork W2386136856 @default.
- W2025183648 hasRelatedWork W2567358723 @default.
- W2025183648 hasVolume "62" @default.
- W2025183648 isParatext "false" @default.
- W2025183648 isRetracted "false" @default.
- W2025183648 magId "2025183648" @default.
- W2025183648 workType "article" @default.