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• W2025201013 abstract "The effects of intraduodenal and dietary lipid on alertness, mood and performance in a task requiring sustained attention were investigated in two studies. The first experiment compared the effect of duodenal infusion of either 100 g/l Intralipid (8·36 kJ/min) or isotonic saline (9 g NaCl/l) in paired studies carried out on two non-consecutive days on five male volunteers. Two consecutive 3 h infusions, one of lipid, the other saline, were given blind on each day using a crossover design. Analysis of variance indicated that lipid significantly reduced alertness ( P < 0·05) and affected the speed and accuracy of performance in a sustained attention task ( P < 0·05). A second experiment compared the effects on eight male volunteers of two isoenergetic lunches of similar appearance, taste and protein content but differing fat and carbohydrate (CHO) contents (fat energy:CHO, 64:18 v . 7:76). Alertness was lower ( P < 0·05) and responses to stimuli in a sustained attention task were slower after the high-fat meal than after the low-fat meal ( P < 0·05). In conclusion, infusion of lipid into the small intestine, and the substitution of fat for carbohydrate while keeping energy and protein constant in a lunch, both cause an enhanced postprandial decline in alertness and concentration. This may be related to the presence of lipid in the small intestine." @default.
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• W2025201013 date "1995-07-01" @default.
• W2025201013 modified "2023-09-28" @default.
• W2025201013 title "Influences of dietary and intraduodenal lipid on alertness, mood, and sustained concentration" @default.
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• W2025201013 doi "https://doi.org/10.1079/bjn19950111" @default.
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