Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025202177> ?p ?o ?g. }
- W2025202177 endingPage "406" @default.
- W2025202177 startingPage "403" @default.
- W2025202177 abstract "TGF-β regulates many aspects of cellular performance relevant to tissue morphogenesis and homeostasis. Postnatal perturbation of TGF-β signaling contributes to the pathogenesis of many disease states, as recently exemplified through the study of Marfan syndrome (MFS), including aortic aneurysm and skeletal muscle myopathy. Heterogeneity in the regulation and consequences of TGF-β signaling, amplified in the context of disease, has engendered confusion and controversy regarding its utility as a therapeutic target. Three studies recently published in the JCI, including one in this issue, underscore the complexity of this subject. Heydemann and colleagues implicate dimorphic variation in latent TGF-β–binding protein 4 (LTBP4), a regulator of TGF-β bioavailability and activation, as a modifier of muscular dystrophy in γ-sarcoglycan–deficient mice. In contrast to experience with ascending aortic aneurysm in MFS, Wang and colleagues show that systemic abrogation of TGF-β signaling worsens (rather than attenuates) Ang II–induced abdominal aortic aneurysm progression in mice. Tieu and colleagues define alterations in the regulation of vascular inflammation in the pathogenesis of Ang II–induced aneurysm and dissection in mice, which may help shed some light on this apparent paradox." @default.
- W2025202177 created "2016-06-24" @default.
- W2025202177 creator A5038027788 @default.
- W2025202177 date "2010-02-01" @default.
- W2025202177 modified "2023-10-05" @default.
- W2025202177 title "TGF-β in the pathogenesis and prevention of disease: a matter of aneurysmic proportions" @default.
- W2025202177 cites W1970532547 @default.
- W2025202177 cites W1976056802 @default.
- W2025202177 cites W1979990833 @default.
- W2025202177 cites W1987844503 @default.
- W2025202177 cites W1993744211 @default.
- W2025202177 cites W1995194065 @default.
- W2025202177 cites W1995592152 @default.
- W2025202177 cites W2022490412 @default.
- W2025202177 cites W2029954991 @default.
- W2025202177 cites W2035630676 @default.
- W2025202177 cites W2039177386 @default.
- W2025202177 cites W2045081428 @default.
- W2025202177 cites W2047942069 @default.
- W2025202177 cites W2054351373 @default.
- W2025202177 cites W2055447043 @default.
- W2025202177 cites W2056774147 @default.
- W2025202177 cites W2058734183 @default.
- W2025202177 cites W2059599014 @default.
- W2025202177 cites W2065699532 @default.
- W2025202177 cites W2066982595 @default.
- W2025202177 cites W2079658573 @default.
- W2025202177 cites W2081344083 @default.
- W2025202177 cites W2084311974 @default.
- W2025202177 cites W2092513068 @default.
- W2025202177 cites W2105195495 @default.
- W2025202177 cites W2109329928 @default.
- W2025202177 cites W2114232003 @default.
- W2025202177 cites W2122588714 @default.
- W2025202177 cites W2123236989 @default.
- W2025202177 cites W2130501433 @default.
- W2025202177 cites W2140858016 @default.
- W2025202177 cites W2146995890 @default.
- W2025202177 cites W2150459172 @default.
- W2025202177 cites W2152350731 @default.
- W2025202177 cites W2155210016 @default.
- W2025202177 cites W2167006869 @default.
- W2025202177 cites W2167966527 @default.
- W2025202177 cites W4239468325 @default.
- W2025202177 doi "https://doi.org/10.1172/jci42014" @default.
- W2025202177 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2810090" @default.
- W2025202177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20101091" @default.
- W2025202177 hasPublicationYear "2010" @default.
- W2025202177 type Work @default.
- W2025202177 sameAs 2025202177 @default.
- W2025202177 citedByCount "107" @default.
- W2025202177 countsByYear W20252021772012 @default.
- W2025202177 countsByYear W20252021772013 @default.
- W2025202177 countsByYear W20252021772014 @default.
- W2025202177 countsByYear W20252021772015 @default.
- W2025202177 countsByYear W20252021772016 @default.
- W2025202177 countsByYear W20252021772017 @default.
- W2025202177 countsByYear W20252021772018 @default.
- W2025202177 countsByYear W20252021772019 @default.
- W2025202177 countsByYear W20252021772020 @default.
- W2025202177 countsByYear W20252021772021 @default.
- W2025202177 countsByYear W20252021772022 @default.
- W2025202177 countsByYear W20252021772023 @default.
- W2025202177 crossrefType "journal-article" @default.
- W2025202177 hasAuthorship W2025202177A5038027788 @default.
- W2025202177 hasBestOaLocation W20252021771 @default.
- W2025202177 hasConcept C142724271 @default.
- W2025202177 hasConcept C151730666 @default.
- W2025202177 hasConcept C203014093 @default.
- W2025202177 hasConcept C2779134260 @default.
- W2025202177 hasConcept C2779343474 @default.
- W2025202177 hasConcept C2780942790 @default.
- W2025202177 hasConcept C71924100 @default.
- W2025202177 hasConcept C86803240 @default.
- W2025202177 hasConceptScore W2025202177C142724271 @default.
- W2025202177 hasConceptScore W2025202177C151730666 @default.
- W2025202177 hasConceptScore W2025202177C203014093 @default.
- W2025202177 hasConceptScore W2025202177C2779134260 @default.
- W2025202177 hasConceptScore W2025202177C2779343474 @default.
- W2025202177 hasConceptScore W2025202177C2780942790 @default.
- W2025202177 hasConceptScore W2025202177C71924100 @default.
- W2025202177 hasConceptScore W2025202177C86803240 @default.
- W2025202177 hasIssue "2" @default.
- W2025202177 hasLocation W20252021771 @default.
- W2025202177 hasLocation W20252021772 @default.
- W2025202177 hasLocation W20252021773 @default.
- W2025202177 hasLocation W20252021774 @default.
- W2025202177 hasOpenAccess W2025202177 @default.
- W2025202177 hasPrimaryLocation W20252021771 @default.
- W2025202177 hasRelatedWork W1972654344 @default.
- W2025202177 hasRelatedWork W2087289419 @default.
- W2025202177 hasRelatedWork W2374607127 @default.
- W2025202177 hasRelatedWork W2391566606 @default.
- W2025202177 hasRelatedWork W2928062689 @default.
- W2025202177 hasRelatedWork W3002609689 @default.
- W2025202177 hasRelatedWork W3029071291 @default.
- W2025202177 hasRelatedWork W3029329823 @default.
- W2025202177 hasRelatedWork W3032540778 @default.