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• W2025202868 abstract "objective To assess whether there is a relationship between the effectiveness of alendronate treatment in postmenopausal women with osteoporosis and BsmI vitamin D receptor (VDR) genotypes. design Prospective baseline-controlled clinical trial. patients Sixty-eight Italian osteoporotic women were enrolled and treated with alendronate at a dose of 10 mg/day for 12 months. measurements At entry and after treatment, lumbar bone mineral density (BMD) and serum osteocalcin (OC) and urinary deoxypyridinoline/creatinine ratio (DPD-Cr) levels were evaluated. DNA was extracted from blood and analysed for the BsmI polymorphism of the VDR gene. results The mean percentage (% ± SD) change from baseline in lumbar BMD was significantly higher (P < 0·01) in bb than in BB BsmI VDR genotypes (7·92 ± 4·31 vs. 3·40 ± 1·81). No significant difference in lumbar BMD was observed in Bb VDR patients (6·01 ± 3·89) in comparison with other groups. The mean percentage of change in serum OC and urinary DPD-Cr levels was significantly (P < 0·01) lower in individuals with bb than in those with BB BsmI VDR genotypes (−14·34 ± 2·87 vs.−10·39 ± 1·43 and −9·61 ± 5·56 vs.−4·61 ± 2·31). No significant difference in serum OC and urinary DPD-Cr levels was observed in Bb VDR patients (−12·31 ± 2·11 and −6·52 ± 2·65) in comparison with other groups. conclusion The different BsmI vitamin D receptor genotypes modify the pharmacological response to alendronate treatment in postmenopausal women with osteoporosis." @default.
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• W2025202868 date "2003-02-28" @default.
• W2025202868 modified "2023-09-23" @default.
• W2025202868 title "Effectiveness of alendronate treatment in postmenopausal women with osteoporosis: relationship with BsmI vitamin D receptor genotypes" @default.
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• W2025202868 doi "https://doi.org/10.1046/j.1365-2265.2003.01724.x" @default.
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