FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025208664> ?p ?o ?g. }

• W2025208664 endingPage "123" @default.
• W2025208664 startingPage "109" @default.
• W2025208664 abstract "Nine patients have been observed with homozygous β thalassaemia in each of whom one parent has a normal level of Hb A2. On the basis of clinical, haematological and globin chain synthesis studies these families have been divided into two groups. Group 1 (six families). Heterozygotes for normal Hb A2–β thalassaemia in this-group showed minimal red cell abnormalities, normal osmotic fragility but imbalanced globin chain synthesis (α/β= 1.6), and appear to correspond to previous descriptions of ‘silent’β thalassaemia. Double heterozygotes with high Hb A2-β thalassaemia have a clinical picture of mild β thalassaemia intermedia characterized by relatively low levels of Hb F (<20%) and γ chain synthesis. Group 2 (three families), β Thalassaemia heterozygotes with normal Hb A2 levels in this group showed more marked red cell abnormalities, decreased osmotic fragility and more imbalanced globin chain synthesis (α/β=2.5) than those in group 1. Double heterozygotes with high Hb A2-β thalassaemia are more severely affected and are transfusion dependent. Haemoglobin F and γ chain synthesis are high in these cases. The frequency of normal Hb A2-β thalassaemia in Greece may be as high as 10% of all β thalassaemia genes and this poses a significant problem for genetic counselling. Various molecular mechanisms are discussed which could account for the heterogeneity within these disorders." @default.
• W2025208664 created "2016-06-24" @default.
• W2025208664 creator A5014134147 @default.
• W2025208664 creator A5015216168 @default.
• W2025208664 creator A5019902976 @default.
• W2025208664 creator A5056986771 @default.
• W2025208664 creator A5082735521 @default.
• W2025208664 date "1979-05-01" @default.
• W2025208664 modified "2023-09-23" @default.
• W2025208664 title "The Heterogeneity of Normal Hb A₂-β Thalassaemia in Greece" @default.
• W2025208664 cites W1518878478 @default.
• W2025208664 cites W1528512169 @default.
• W2025208664 cites W1547680166 @default.
• W2025208664 cites W1973366976 @default.
• W2025208664 cites W1976169741 @default.
• W2025208664 cites W1980140711 @default.
• W2025208664 cites W1984192423 @default.
• W2025208664 cites W1989335639 @default.
• W2025208664 cites W1998578018 @default.
• W2025208664 cites W2000209787 @default.
• W2025208664 cites W2000302335 @default.
• W2025208664 cites W2010189003 @default.
• W2025208664 cites W2013567938 @default.
• W2025208664 cites W2038126541 @default.
• W2025208664 cites W2042759445 @default.
• W2025208664 cites W2058772523 @default.
• W2025208664 cites W2075177268 @default.
• W2025208664 cites W2078735501 @default.
• W2025208664 cites W2078924513 @default.
• W2025208664 cites W2118957392 @default.
• W2025208664 cites W2128346477 @default.
• W2025208664 cites W2158926190 @default.
• W2025208664 cites W2169003099 @default.
• W2025208664 cites W2199559446 @default.
• W2025208664 cites W2340999374 @default.
• W2025208664 cites W2404368999 @default.
• W2025208664 doi "https://doi.org/10.1111/j.1365-2141.1979.tb03703.x" @default.
• W2025208664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/465353" @default.
• W2025208664 hasPublicationYear "1979" @default.
• W2025208664 type Work @default.
• W2025208664 sameAs 2025208664 @default.
• W2025208664 citedByCount "51" @default.
• W2025208664 countsByYear W20252086642013 @default.
• W2025208664 countsByYear W20252086642017 @default.
• W2025208664 countsByYear W20252086642018 @default.
• W2025208664 countsByYear W20252086642019 @default.
• W2025208664 countsByYear W20252086642021 @default.
• W2025208664 countsByYear W20252086642022 @default.
• W2025208664 countsByYear W20252086642023 @default.
• W2025208664 crossrefType "journal-article" @default.
• W2025208664 hasAuthorship W2025208664A5014134147 @default.
• W2025208664 hasAuthorship W2025208664A5015216168 @default.
• W2025208664 hasAuthorship W2025208664A5019902976 @default.
• W2025208664 hasAuthorship W2025208664A5056986771 @default.
• W2025208664 hasAuthorship W2025208664A5082735521 @default.
• W2025208664 hasConcept C104317684 @default.
• W2025208664 hasConcept C125996951 @default.
• W2025208664 hasConcept C126322002 @default.
• W2025208664 hasConcept C134018914 @default.
• W2025208664 hasConcept C135763542 @default.
• W2025208664 hasConcept C147509754 @default.
• W2025208664 hasConcept C153471976 @default.
• W2025208664 hasConcept C2776175824 @default.
• W2025208664 hasConcept C2777208419 @default.
• W2025208664 hasConcept C2777216359 @default.
• W2025208664 hasConcept C2777799968 @default.
• W2025208664 hasConcept C2779668550 @default.
• W2025208664 hasConcept C2779902561 @default.
• W2025208664 hasConcept C2909410647 @default.
• W2025208664 hasConcept C2992013202 @default.
• W2025208664 hasConcept C54355233 @default.
• W2025208664 hasConcept C71924100 @default.
• W2025208664 hasConcept C86803240 @default.
• W2025208664 hasConceptScore W2025208664C104317684 @default.
• W2025208664 hasConceptScore W2025208664C125996951 @default.
• W2025208664 hasConceptScore W2025208664C126322002 @default.
• W2025208664 hasConceptScore W2025208664C134018914 @default.
• W2025208664 hasConceptScore W2025208664C135763542 @default.
• W2025208664 hasConceptScore W2025208664C147509754 @default.
• W2025208664 hasConceptScore W2025208664C153471976 @default.
• W2025208664 hasConceptScore W2025208664C2776175824 @default.
• W2025208664 hasConceptScore W2025208664C2777208419 @default.
• W2025208664 hasConceptScore W2025208664C2777216359 @default.
• W2025208664 hasConceptScore W2025208664C2777799968 @default.
• W2025208664 hasConceptScore W2025208664C2779668550 @default.
• W2025208664 hasConceptScore W2025208664C2779902561 @default.
• W2025208664 hasConceptScore W2025208664C2909410647 @default.
• W2025208664 hasConceptScore W2025208664C2992013202 @default.
• W2025208664 hasConceptScore W2025208664C54355233 @default.
• W2025208664 hasConceptScore W2025208664C71924100 @default.
• W2025208664 hasConceptScore W2025208664C86803240 @default.
• W2025208664 hasIssue "1" @default.
• W2025208664 hasLocation W20252086641 @default.
• W2025208664 hasLocation W20252086642 @default.
• W2025208664 hasOpenAccess W2025208664 @default.
• W2025208664 hasPrimaryLocation W20252086641 @default.
• W2025208664 hasRelatedWork W1972691251 @default.
• W2025208664 hasRelatedWork W2002956818 @default.

• next