FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025212911> ?p ?o ?g. }

• W2025212911 endingPage "55" @default.
• W2025212911 startingPage "52" @default.
• W2025212911 abstract "Sulindac suppresses the growth of colon polyps in Gardner syndrome and familial adenomatous polyposis. The mechanism of action is not known. The problems are to ascertain the significance of high prostaglandin concentrations in transformed cells, colon polyps and cancers and to explain how sulindac restores normal growth patterns. A few clinical observations and an abundance of experimental data can be integrated to produce a reasonable model based on current biochemical and physiologic concepts. A fundamental defect in the formation of colon polyps is mutation of the APC (adenomatous polyposis coli) gene that leads to inadequate suppression of proliferation. There is high PGE2 content in colon polyps and cancers, presumably the result of stimulation by protein kinase C (PKC). In small quantities it stimulates cyclic AMP production but with persistent high concentrations it desensitizes and down-regulates specific PG receptors and inactivates adenylate cyclase, cAMP synthesis, and the cAMP-dependent mechanism for control of proliferation. The PKC pathway is thereby unopposed. It is hypothesized that restriction of PG synthesis by sulindac is accompanied by resensitization of PG receptors, and reactivation of the cAMP-dependent pathway for control of cell growth. It is further postulated that restoration of cAMP synthesis and protein kinase A activity converts a functionally inadequate mutant APC suppressor gene to one sufficient to inhibit colon polyp formation. © Wiley-Liss, Inc." @default.
• W2025212911 created "2016-06-24" @default.
• W2025212911 creator A5069054159 @default.
• W2025212911 date "1994-01-01" @default.
• W2025212911 modified "2023-09-23" @default.
• W2025212911 title "The effect of sulindac on colon polyps: Circumvention of a transformed phenotype—A hypothesis" @default.
• W2025212911 cites W157353910 @default.
• W2025212911 cites W1783022590 @default.
• W2025212911 cites W1964839077 @default.
• W2025212911 cites W1973577382 @default.
• W2025212911 cites W1975993620 @default.
• W2025212911 cites W1977825470 @default.
• W2025212911 cites W1979618971 @default.
• W2025212911 cites W1980909735 @default.
• W2025212911 cites W1995161590 @default.
• W2025212911 cites W1995568029 @default.
• W2025212911 cites W2006874765 @default.
• W2025212911 cites W2013581100 @default.
• W2025212911 cites W2018348035 @default.
• W2025212911 cites W2024068070 @default.
• W2025212911 cites W2028215641 @default.
• W2025212911 cites W2029431152 @default.
• W2025212911 cites W2033255776 @default.
• W2025212911 cites W2050943200 @default.
• W2025212911 cites W2050999934 @default.
• W2025212911 cites W2054363987 @default.
• W2025212911 cites W2057252291 @default.
• W2025212911 cites W2057445144 @default.
• W2025212911 cites W2058403714 @default.
• W2025212911 cites W2059813946 @default.
• W2025212911 cites W2062250423 @default.
• W2025212911 cites W2064610337 @default.
• W2025212911 cites W2065851152 @default.
• W2025212911 cites W2082797919 @default.
• W2025212911 cites W2095018874 @default.
• W2025212911 cites W2115645802 @default.
• W2025212911 cites W2148018436 @default.
• W2025212911 cites W2168962087 @default.
• W2025212911 cites W2336215030 @default.
• W2025212911 cites W4236533725 @default.
• W2025212911 doi "https://doi.org/10.1002/jso.2930550114" @default.
• W2025212911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8289454" @default.
• W2025212911 hasPublicationYear "1994" @default.
• W2025212911 type Work @default.
• W2025212911 sameAs 2025212911 @default.
• W2025212911 citedByCount "11" @default.
• W2025212911 crossrefType "journal-article" @default.
• W2025212911 hasAuthorship W2025212911A5069054159 @default.
• W2025212911 hasConcept C121608353 @default.
• W2025212911 hasConcept C126322002 @default.
• W2025212911 hasConcept C134018914 @default.
• W2025212911 hasConcept C170493617 @default.
• W2025212911 hasConcept C180526460 @default.
• W2025212911 hasConcept C184235292 @default.
• W2025212911 hasConcept C195794163 @default.
• W2025212911 hasConcept C24998067 @default.
• W2025212911 hasConcept C2776241388 @default.
• W2025212911 hasConcept C2778237340 @default.
• W2025212911 hasConcept C2778484676 @default.
• W2025212911 hasConcept C2780069284 @default.
• W2025212911 hasConcept C2780814781 @default.
• W2025212911 hasConcept C502942594 @default.
• W2025212911 hasConcept C526805850 @default.
• W2025212911 hasConcept C54355233 @default.
• W2025212911 hasConcept C62112901 @default.
• W2025212911 hasConcept C62478195 @default.
• W2025212911 hasConcept C71924100 @default.
• W2025212911 hasConcept C86803240 @default.
• W2025212911 hasConcept C95444343 @default.
• W2025212911 hasConcept C97029542 @default.
• W2025212911 hasConceptScore W2025212911C121608353 @default.
• W2025212911 hasConceptScore W2025212911C126322002 @default.
• W2025212911 hasConceptScore W2025212911C134018914 @default.
• W2025212911 hasConceptScore W2025212911C170493617 @default.
• W2025212911 hasConceptScore W2025212911C180526460 @default.
• W2025212911 hasConceptScore W2025212911C184235292 @default.
• W2025212911 hasConceptScore W2025212911C195794163 @default.
• W2025212911 hasConceptScore W2025212911C24998067 @default.
• W2025212911 hasConceptScore W2025212911C2776241388 @default.
• W2025212911 hasConceptScore W2025212911C2778237340 @default.
• W2025212911 hasConceptScore W2025212911C2778484676 @default.
• W2025212911 hasConceptScore W2025212911C2780069284 @default.
• W2025212911 hasConceptScore W2025212911C2780814781 @default.
• W2025212911 hasConceptScore W2025212911C502942594 @default.
• W2025212911 hasConceptScore W2025212911C526805850 @default.
• W2025212911 hasConceptScore W2025212911C54355233 @default.
• W2025212911 hasConceptScore W2025212911C62112901 @default.
• W2025212911 hasConceptScore W2025212911C62478195 @default.
• W2025212911 hasConceptScore W2025212911C71924100 @default.
• W2025212911 hasConceptScore W2025212911C86803240 @default.
• W2025212911 hasConceptScore W2025212911C95444343 @default.
• W2025212911 hasConceptScore W2025212911C97029542 @default.
• W2025212911 hasIssue "1" @default.
• W2025212911 hasLocation W20252129111 @default.
• W2025212911 hasLocation W20252129112 @default.
• W2025212911 hasOpenAccess W2025212911 @default.
• W2025212911 hasPrimaryLocation W20252129111 @default.
• W2025212911 hasRelatedWork W1978419663 @default.

• next