Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025221888> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2025221888 endingPage "269" @default.
- W2025221888 startingPage "264" @default.
- W2025221888 abstract "The potent inflammatory mediator PAF-acether (PAF = platelet-activating factor) can produce the same hemodynamic and hematological effects as protamine infusion. In 10 patients, blood PAF and precursor levels were measured in the left atrium, the pulmonary and the radial artery before and after protamine reversal of heparin during coronary artery bypass graft. Blood PAF level in the left atrium increased 6-fold (17 ± 12 pg ± ml-1 vs 98 ± 46 pg ± ml-1, P = 0.03) after protamine infusion. By contrast, a 4-fold decrease was observed in the pulmonary artery blood (130 ± 48 pg ± ml-1 vs 31 ± 23 pg ± m-1, P = 0.03) and a 9-fold decrease was noted in the radial artery blood (285 ± 104 pg ± ml-1 vs 31 ± 15 pg ± ml-1, P = 0.01). No cardiovascular impairment was observed but all patients exhibited thrombocytopenia. After protamine, PAF in the left atrium reached lower levels than those observed in the pulmonary and radial artery before protamine infusion. Moreover, no significant correlation was observed between platelet counts and PAF levels. Thus PAF seems not to mediate the platelet drop induced by heparin-protamine complexes. A positive correlation was obtained between leukocyte counts in the pulmonary artery and PAF levels in the left atrium (r = 0.78, P = 0.02). Protamine infusion may stimulate PAF biosynthesis by leukocytes in the lung, on the one hand, and accelerate the disappearance of PAF in the arterial bed, on the other hand." @default.
- W2025221888 created "2016-06-24" @default.
- W2025221888 creator A5000466150 @default.
- W2025221888 creator A5015498856 @default.
- W2025221888 creator A5063574799 @default.
- W2025221888 creator A5088110193 @default.
- W2025221888 creator A5088997063 @default.
- W2025221888 creator A5090474227 @default.
- W2025221888 date "1992-04-01" @default.
- W2025221888 modified "2023-10-17" @default.
- W2025221888 title "Variations in blood platelet-activating-factor levels after protamine reversal of heparin in humans" @default.
- W2025221888 cites W1547302919 @default.
- W2025221888 cites W1696734442 @default.
- W2025221888 cites W1893528652 @default.
- W2025221888 cites W1973226207 @default.
- W2025221888 cites W1976345463 @default.
- W2025221888 cites W1993080576 @default.
- W2025221888 cites W2009657071 @default.
- W2025221888 cites W2033899018 @default.
- W2025221888 cites W2036719864 @default.
- W2025221888 cites W2042039669 @default.
- W2025221888 cites W2043464980 @default.
- W2025221888 cites W2043934481 @default.
- W2025221888 cites W2053056534 @default.
- W2025221888 cites W2056928834 @default.
- W2025221888 cites W2059611182 @default.
- W2025221888 cites W2059687247 @default.
- W2025221888 cites W2060507826 @default.
- W2025221888 cites W2077087470 @default.
- W2025221888 cites W2107314850 @default.
- W2025221888 cites W2115227500 @default.
- W2025221888 cites W2157823999 @default.
- W2025221888 cites W2161183896 @default.
- W2025221888 cites W2187982708 @default.
- W2025221888 cites W2229309923 @default.
- W2025221888 cites W2398302851 @default.
- W2025221888 cites W4321746742 @default.
- W2025221888 cites W64761778 @default.
- W2025221888 doi "https://doi.org/10.1111/j.1399-6576.1992.tb03462.x" @default.
- W2025221888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1574976" @default.
- W2025221888 hasPublicationYear "1992" @default.
- W2025221888 type Work @default.
- W2025221888 sameAs 2025221888 @default.
- W2025221888 citedByCount "9" @default.
- W2025221888 countsByYear W20252218882021 @default.
- W2025221888 crossrefType "journal-article" @default.
- W2025221888 hasAuthorship W2025221888A5000466150 @default.
- W2025221888 hasAuthorship W2025221888A5015498856 @default.
- W2025221888 hasAuthorship W2025221888A5063574799 @default.
- W2025221888 hasAuthorship W2025221888A5088110193 @default.
- W2025221888 hasAuthorship W2025221888A5088997063 @default.
- W2025221888 hasAuthorship W2025221888A5090474227 @default.
- W2025221888 hasConcept C126322002 @default.
- W2025221888 hasConcept C134018914 @default.
- W2025221888 hasConcept C164705383 @default.
- W2025221888 hasConcept C2776820930 @default.
- W2025221888 hasConcept C2777557582 @default.
- W2025221888 hasConcept C2779020240 @default.
- W2025221888 hasConcept C2779354726 @default.
- W2025221888 hasConcept C2780835560 @default.
- W2025221888 hasConcept C2780940725 @default.
- W2025221888 hasConcept C42219234 @default.
- W2025221888 hasConcept C71924100 @default.
- W2025221888 hasConcept C89560881 @default.
- W2025221888 hasConceptScore W2025221888C126322002 @default.
- W2025221888 hasConceptScore W2025221888C134018914 @default.
- W2025221888 hasConceptScore W2025221888C164705383 @default.
- W2025221888 hasConceptScore W2025221888C2776820930 @default.
- W2025221888 hasConceptScore W2025221888C2777557582 @default.
- W2025221888 hasConceptScore W2025221888C2779020240 @default.
- W2025221888 hasConceptScore W2025221888C2779354726 @default.
- W2025221888 hasConceptScore W2025221888C2780835560 @default.
- W2025221888 hasConceptScore W2025221888C2780940725 @default.
- W2025221888 hasConceptScore W2025221888C42219234 @default.
- W2025221888 hasConceptScore W2025221888C71924100 @default.
- W2025221888 hasConceptScore W2025221888C89560881 @default.
- W2025221888 hasIssue "3" @default.
- W2025221888 hasLocation W20252218881 @default.
- W2025221888 hasLocation W20252218882 @default.
- W2025221888 hasOpenAccess W2025221888 @default.
- W2025221888 hasPrimaryLocation W20252218881 @default.
- W2025221888 hasRelatedWork W1990281441 @default.
- W2025221888 hasRelatedWork W2017066394 @default.
- W2025221888 hasRelatedWork W2020026444 @default.
- W2025221888 hasRelatedWork W2025221888 @default.
- W2025221888 hasRelatedWork W2029384334 @default.
- W2025221888 hasRelatedWork W2094249446 @default.
- W2025221888 hasRelatedWork W2289246044 @default.
- W2025221888 hasRelatedWork W2406131218 @default.
- W2025221888 hasRelatedWork W2413335030 @default.
- W2025221888 hasRelatedWork W2417842026 @default.
- W2025221888 hasVolume "36" @default.
- W2025221888 isParatext "false" @default.
- W2025221888 isRetracted "false" @default.
- W2025221888 magId "2025221888" @default.
- W2025221888 workType "article" @default.