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- W2025231699 abstract "Bacterial epiphytes isolated from marine eukaryotes were screened for the production of quorum sensing inhibitory compounds (QSIs). Marine isolate KS8, identified as a Pseudoalteromonas sp., was found to display strong quorum sensing inhibitory (QSI) activity against acyl homoserine lactone (AHL)-based reporter strains Chromobacterium violaceum ATCC 12472 and CV026. KS8 supernatant significantly reduced biofilm biomass during biofilm formation (−63%) and in pre-established, mature P. aeruginosa PAO1 biofilms (−33%). KS8 supernatant also caused a 0.97-log reduction (−89%) and a 2-log reduction (−99%) in PAO1 biofilm viable counts in the biofilm formation assay and the biofilm eradication assay respectively. The crude organic extract of KS8 had a minimum inhibitory concentration (MIC) of 2 mg/mL against PAO1 but no minimum bactericidal concentration (MBC) was observed over the concentration range tested (MBC > 16 mg/mL). Sub-MIC concentrations (1 mg/mL) of KS8 crude organic extract significantly reduced the quorum sensing (QS)-dependent production of both pyoverdin and pyocyanin in P. aeruginosa PAO1 without affecting growth. A combinatorial approach using tobramycin and the crude organic extract at 1 mg/mL against planktonic P. aeruginosa PAO1 was found to increase the efficacy of tobramycin ten-fold, decreasing the MIC from 0.75 to 0.075 µg/mL. These data support the validity of approaches combining conventional antibiotic therapy with non-antibiotic compounds to improve the efficacy of current treatments." @default.
- W2025231699 created "2016-06-24" @default.
- W2025231699 creator A5003246006 @default.
- W2025231699 creator A5009018290 @default.
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- W2025231699 creator A5043272864 @default.
- W2025231699 creator A5053533247 @default.
- W2025231699 creator A5069976505 @default.
- W2025231699 date "2014-12-24" @default.
- W2025231699 modified "2023-09-27" @default.
- W2025231699 title "Marine-Derived Quorum-Sensing Inhibitory Activities Enhance the Antibacterial Efficacy of Tobramycin against Pseudomonas aeruginosa" @default.
- W2025231699 cites W1536782587 @default.
- W2025231699 cites W1703657909 @default.
- W2025231699 cites W1927570869 @default.
- W2025231699 cites W1943112463 @default.
- W2025231699 cites W1967658858 @default.
- W2025231699 cites W1981740703 @default.
- W2025231699 cites W1981804299 @default.
- W2025231699 cites W1987142741 @default.
- W2025231699 cites W1987784997 @default.
- W2025231699 cites W2002810519 @default.
- W2025231699 cites W2005361874 @default.
- W2025231699 cites W2007176538 @default.
- W2025231699 cites W2015576468 @default.
- W2025231699 cites W2017821807 @default.
- W2025231699 cites W2018337214 @default.
- W2025231699 cites W2018917527 @default.
- W2025231699 cites W2019176012 @default.
- W2025231699 cites W2034719937 @default.
- W2025231699 cites W2036543661 @default.
- W2025231699 cites W2043535514 @default.
- W2025231699 cites W2057153376 @default.
- W2025231699 cites W2057910559 @default.
- W2025231699 cites W2062374558 @default.
- W2025231699 cites W2064292111 @default.
- W2025231699 cites W2064612941 @default.
- W2025231699 cites W2073233593 @default.
- W2025231699 cites W2074457663 @default.
- W2025231699 cites W2075815893 @default.
- W2025231699 cites W2085360512 @default.
- W2025231699 cites W2087548640 @default.
- W2025231699 cites W2092643722 @default.
- W2025231699 cites W2093763294 @default.
- W2025231699 cites W2095783952 @default.
- W2025231699 cites W2096861885 @default.
- W2025231699 cites W2097396161 @default.
- W2025231699 cites W2097478029 @default.
- W2025231699 cites W2098894017 @default.
- W2025231699 cites W2100723520 @default.
- W2025231699 cites W2101273146 @default.
- W2025231699 cites W2101380390 @default.
- W2025231699 cites W2101773986 @default.
- W2025231699 cites W2102320488 @default.
- W2025231699 cites W2102672963 @default.
- W2025231699 cites W2103807926 @default.
- W2025231699 cites W2104462602 @default.
- W2025231699 cites W2106351298 @default.
- W2025231699 cites W2106758768 @default.
- W2025231699 cites W2107757630 @default.
- W2025231699 cites W2111119966 @default.
- W2025231699 cites W2111209798 @default.
- W2025231699 cites W2111315625 @default.
- W2025231699 cites W2112467720 @default.
- W2025231699 cites W2112715754 @default.
- W2025231699 cites W2115486016 @default.
- W2025231699 cites W2116464526 @default.
- W2025231699 cites W2117756034 @default.
- W2025231699 cites W2119365294 @default.
- W2025231699 cites W2119410664 @default.
- W2025231699 cites W2123273873 @default.
- W2025231699 cites W2125040423 @default.
- W2025231699 cites W2125268958 @default.
- W2025231699 cites W2126922170 @default.
- W2025231699 cites W2127993713 @default.
- W2025231699 cites W2130490459 @default.
- W2025231699 cites W2131036374 @default.
- W2025231699 cites W2131203626 @default.
- W2025231699 cites W2132658610 @default.
- W2025231699 cites W2133188372 @default.
- W2025231699 cites W2136294927 @default.
- W2025231699 cites W2136931384 @default.
- W2025231699 cites W2137215017 @default.
- W2025231699 cites W2137659876 @default.
- W2025231699 cites W2141016491 @default.
- W2025231699 cites W2141425531 @default.
- W2025231699 cites W2144420520 @default.
- W2025231699 cites W2146157756 @default.
- W2025231699 cites W2146292204 @default.
- W2025231699 cites W2149908911 @default.
- W2025231699 cites W2155439177 @default.
- W2025231699 cites W2155448001 @default.
- W2025231699 cites W2161072592 @default.
- W2025231699 cites W2163139680 @default.
- W2025231699 cites W2165991316 @default.
- W2025231699 cites W2166740816 @default.
- W2025231699 cites W2473090706 @default.
- W2025231699 cites W4254375966 @default.
- W2025231699 cites W4255703481 @default.