FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025235514> ?p ?o ?g. }

• W2025235514 endingPage "e49730" @default.
• W2025235514 startingPage "e49730" @default.
• W2025235514 abstract "Optic nerve atrophy caused by abnormal intraocular pressure (IOP) remains the most common cause of irreversible loss of vision worldwide. The aim of this study was to determine whether topically applied IOP-lowering eye drugs affect retinal ganglion cells (RGCs) and retinal metabolism in a rat model of optic neuropathy. IOP was elevated through cauterization of episcleral veins, and then lowered either by the daily topical application of timolol, timolol/travoprost, timolol/dorzolamide, or timolol/brimonidine, or surgically with sectorial iridectomy. RGCs were retrogradely labeled 4 days prior to enucleation, and counted. Two-dimensional polyacrylamide gel electrophoresis (2D-PAGE), matrix-assisted laser desorption ionization mass spectrometry, Western blotting, and immunohistochemistry allowed the identification of IOP-dependent proteomic changes. Genomic changes were scrutinized using microarrays and qRT-PCR. The significant increase in IOP induced by episcleral vein cauterization that persisted until 8 weeks of follow-up in control animals (p<0.05) was effectively lowered by the eye drops (p<0.05). As anticipated, the number of RGCs decreased significantly following 8 weeks of elevated IOP (p<0.05), while treatment with combination compounds markedly improved RGC survival (p<0.05). 2D-PAGE and Western blot analyses revealed an IOP-dependent expression of crystallin cry-βb2. Microarray and qRT-PCR analyses verified the results at the mRNA level. IHC demonstrated that crystallins were expressed mainly in the ganglion cell layer. The data suggest that IOP and either topically applied antiglaucomatous drugs influence crystallin expression within the retina. Neuronal crystallins are thus suitable biomarkers for monitoring the progression of neuropathy and evaluating any neuroprotective effects." @default.
• W2025235514 created "2016-06-24" @default.
• W2025235514 creator A5003030738 @default.
• W2025235514 creator A5010453022 @default.
• W2025235514 creator A5077352261 @default.
• W2025235514 date "2013-02-26" @default.
• W2025235514 modified "2023-10-18" @default.
• W2025235514 title "Crystallins Are Regulated Biomarkers for Monitoring Topical Therapy of Glaucomatous Optic Neuropathy" @default.
• W2025235514 cites W1606423922 @default.
• W2025235514 cites W1964241219 @default.
• W2025235514 cites W1965181383 @default.
• W2025235514 cites W1971884595 @default.
• W2025235514 cites W1976659696 @default.
• W2025235514 cites W1987558683 @default.
• W2025235514 cites W1989399186 @default.
• W2025235514 cites W1995971435 @default.
• W2025235514 cites W1997664154 @default.
• W2025235514 cites W2000549923 @default.
• W2025235514 cites W2004135735 @default.
• W2025235514 cites W2016192215 @default.
• W2025235514 cites W2016444344 @default.
• W2025235514 cites W2022263796 @default.
• W2025235514 cites W2025752516 @default.
• W2025235514 cites W2031002260 @default.
• W2025235514 cites W2031607196 @default.
• W2025235514 cites W2033123702 @default.
• W2025235514 cites W2036839837 @default.
• W2025235514 cites W2040768342 @default.
• W2025235514 cites W2050709270 @default.
• W2025235514 cites W2060401858 @default.
• W2025235514 cites W2065335617 @default.
• W2025235514 cites W2077441886 @default.
• W2025235514 cites W2083533391 @default.
• W2025235514 cites W2084352924 @default.
• W2025235514 cites W2086791741 @default.
• W2025235514 cites W2087711396 @default.
• W2025235514 cites W2088463918 @default.
• W2025235514 cites W2100159037 @default.
• W2025235514 cites W2100837269 @default.
• W2025235514 cites W2122573572 @default.
• W2025235514 cites W2127203825 @default.
• W2025235514 cites W2138123612 @default.
• W2025235514 cites W2149062776 @default.
• W2025235514 cites W2155694082 @default.
• W2025235514 cites W2330993383 @default.
• W2025235514 cites W2094609113 @default.
• W2025235514 doi "https://doi.org/10.1371/journal.pone.0049730" @default.
• W2025235514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3582637" @default.
• W2025235514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23468831" @default.
• W2025235514 hasPublicationYear "2013" @default.
• W2025235514 type Work @default.
• W2025235514 sameAs 2025235514 @default.
• W2025235514 citedByCount "16" @default.
• W2025235514 countsByYear W20252355142014 @default.
• W2025235514 countsByYear W20252355142017 @default.
• W2025235514 countsByYear W20252355142018 @default.
• W2025235514 countsByYear W20252355142019 @default.
• W2025235514 countsByYear W20252355142020 @default.
• W2025235514 countsByYear W20252355142022 @default.
• W2025235514 countsByYear W20252355142023 @default.
• W2025235514 crossrefType "journal-article" @default.
• W2025235514 hasAuthorship W2025235514A5003030738 @default.
• W2025235514 hasAuthorship W2025235514A5010453022 @default.
• W2025235514 hasAuthorship W2025235514A5077352261 @default.
• W2025235514 hasBestOaLocation W20252355141 @default.
• W2025235514 hasConcept C118487528 @default.
• W2025235514 hasConcept C142724271 @default.
• W2025235514 hasConcept C2776521421 @default.
• W2025235514 hasConcept C2776727336 @default.
• W2025235514 hasConcept C2777624874 @default.
• W2025235514 hasConcept C2778073030 @default.
• W2025235514 hasConcept C2778190193 @default.
• W2025235514 hasConcept C2778233873 @default.
• W2025235514 hasConcept C2778527774 @default.
• W2025235514 hasConcept C2780837183 @default.
• W2025235514 hasConcept C2781092963 @default.
• W2025235514 hasConcept C71924100 @default.
• W2025235514 hasConceptScore W2025235514C118487528 @default.
• W2025235514 hasConceptScore W2025235514C142724271 @default.
• W2025235514 hasConceptScore W2025235514C2776521421 @default.
• W2025235514 hasConceptScore W2025235514C2776727336 @default.
• W2025235514 hasConceptScore W2025235514C2777624874 @default.
• W2025235514 hasConceptScore W2025235514C2778073030 @default.
• W2025235514 hasConceptScore W2025235514C2778190193 @default.
• W2025235514 hasConceptScore W2025235514C2778233873 @default.
• W2025235514 hasConceptScore W2025235514C2778527774 @default.
• W2025235514 hasConceptScore W2025235514C2780837183 @default.
• W2025235514 hasConceptScore W2025235514C2781092963 @default.
• W2025235514 hasConceptScore W2025235514C71924100 @default.
• W2025235514 hasIssue "2" @default.
• W2025235514 hasLocation W20252355141 @default.
• W2025235514 hasLocation W20252355142 @default.
• W2025235514 hasLocation W20252355143 @default.
• W2025235514 hasLocation W20252355144 @default.
• W2025235514 hasOpenAccess W2025235514 @default.
• W2025235514 hasPrimaryLocation W20252355141 @default.
• W2025235514 hasRelatedWork W1970476186 @default.
• W2025235514 hasRelatedWork W1979215550 @default.

• next