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- W2025236008 abstract "To the Editor. —The report by Weiss et al 1 as well as the accompanying editorial 2 engender vast medical, economic, and social considerations. Pronouncements such as these should be founded on extensive and scientifically sound data and conclusions, which we found lacking in this study. The conclusions of the study are based on a combination of clinical and histopathologic findings in 30 patients (only 15 patients were treated on their faces) after only four months of treatment with topical tretinoin cream. All clinical findings are based on the subjective observations of a single observer. Clearly, any conclusions suggesting reversal of 35 to 70 years (range of patient ages) of photoaging are tenuous and premature. The main difficulty, however, is that the study is not, as stated in the subtitle, double-blind. Fully 92% of patients treated with tretinoin experienced an irritant dermatitis. This required administration of potent topical steroids to" @default.
- W2025236008 created "2016-06-24" @default.
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- W2025236008 date "1988-06-10" @default.
- W2025236008 modified "2023-09-27" @default.
- W2025236008 title "Topical Tretinoin for Photoaged Skin" @default.
- W2025236008 cites W2009833095 @default.
- W2025236008 cites W2072152713 @default.
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- W2025236008 doi "https://doi.org/10.1001/jama.1988.03720220019016" @default.
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