FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025237647> ?p ?o ?g. }

• W2025237647 endingPage "187" @default.
• W2025237647 startingPage "173" @default.
• W2025237647 abstract "EGF is believed to play an important role in the regulation of placental function. We have examined in detail, the effect of 50–200 ng/ml EGF on first trimester (7–13 gestational weeks) placental human chorionic gonadotropin (hCG) secretion using both static (explants and isolated cells) and kinetic (superfusion of explants) culture methods. In 7–9 week explants, short (1–4 minutes) pulses of EGF increased both the rate and amplitude of spontaneous hCG pulses. This effect was dose dependent and the concentration of 50 ng/ml was the most effective. Addition of 50 ng/ml EGF for 90 minutes in superfusion caused an initial increase followed by a significant decrease in spontaneous pulsatile hCG secretion. hCG secretion was not affected by a subsequent addition of a one minute pulse of 50 ng/ml EGF, reflecting desensitization. A gestational age dependent delayed effect of EGF wsas documented. At 7–9 weeks, following overnight preincubation with 50 ng/ml EGF, there was a significant increase in hCG pulse parameters as calculated by PULSAR. In contrast, at >10 weeks, the growth factor effect was inhibitory. In explants cultured for 24 hours, the same trend was noted at 7–9 weeks. EGF caused a two-fold increase while >11 week, the effect was markedly inhibitory. In isolated trophoblastic cell cultures, EGF added daily for the first week increase in hCG secretion until the fifth day. However, apparently no morphological changes were associated with this increase. In conclusion, EGF has a gestational dependent rapid, long term, and delayed effect on hCG secretion in the first trimester. The involvement of EGF in control of hCG secretion is strongly suggested." @default.
• W2025237647 created "2016-06-24" @default.
• W2025237647 creator A5014286548 @default.
• W2025237647 creator A5062023248 @default.
• W2025237647 creator A5062683181 @default.
• W2025237647 creator A5063644333 @default.
• W2025237647 date "1992-01-01" @default.
• W2025237647 modified "2023-09-24" @default.
• W2025237647 title "Gestational age dependent, rapid and delayed effect of epidermal growth factor upon human chorionic gonadotropin secretion by the first trimester explants" @default.
• W2025237647 cites W1775749144 @default.
• W2025237647 cites W1964259693 @default.
• W2025237647 cites W1967003411 @default.
• W2025237647 cites W1987636666 @default.
• W2025237647 cites W1987847340 @default.
• W2025237647 cites W2001074679 @default.
• W2025237647 cites W2002464919 @default.
• W2025237647 cites W2003793042 @default.
• W2025237647 cites W2004665876 @default.
• W2025237647 cites W2008404089 @default.
• W2025237647 cites W2009770777 @default.
• W2025237647 cites W2010229509 @default.
• W2025237647 cites W2029106536 @default.
• W2025237647 cites W2030700663 @default.
• W2025237647 cites W2041791001 @default.
• W2025237647 cites W2042084319 @default.
• W2025237647 cites W2059741629 @default.
• W2025237647 cites W2111768027 @default.
• W2025237647 cites W2144860277 @default.
• W2025237647 cites W2162481811 @default.
• W2025237647 cites W2272253461 @default.
• W2025237647 cites W2415554524 @default.
• W2025237647 doi "https://doi.org/10.1016/s0143-4004(05)80314-5" @default.
• W2025237647 hasPublicationYear "1992" @default.
• W2025237647 type Work @default.
• W2025237647 sameAs 2025237647 @default.
• W2025237647 citedByCount "0" @default.
• W2025237647 crossrefType "journal-article" @default.
• W2025237647 hasAuthorship W2025237647A5014286548 @default.
• W2025237647 hasAuthorship W2025237647A5062023248 @default.
• W2025237647 hasAuthorship W2025237647A5062683181 @default.
• W2025237647 hasAuthorship W2025237647A5063644333 @default.
• W2025237647 hasConcept C126322002 @default.
• W2025237647 hasConcept C134018914 @default.
• W2025237647 hasConcept C16685009 @default.
• W2025237647 hasConcept C170493617 @default.
• W2025237647 hasConcept C172680121 @default.
• W2025237647 hasConcept C2775948956 @default.
• W2025237647 hasConcept C2776362946 @default.
• W2025237647 hasConcept C2776953305 @default.
• W2025237647 hasConcept C2777495146 @default.
• W2025237647 hasConcept C2778376644 @default.
• W2025237647 hasConcept C2778782382 @default.
• W2025237647 hasConcept C2779234561 @default.
• W2025237647 hasConcept C49039625 @default.
• W2025237647 hasConcept C54355233 @default.
• W2025237647 hasConcept C71315377 @default.
• W2025237647 hasConcept C71924100 @default.
• W2025237647 hasConcept C79191276 @default.
• W2025237647 hasConcept C86803240 @default.
• W2025237647 hasConceptScore W2025237647C126322002 @default.
• W2025237647 hasConceptScore W2025237647C134018914 @default.
• W2025237647 hasConceptScore W2025237647C16685009 @default.
• W2025237647 hasConceptScore W2025237647C170493617 @default.
• W2025237647 hasConceptScore W2025237647C172680121 @default.
• W2025237647 hasConceptScore W2025237647C2775948956 @default.
• W2025237647 hasConceptScore W2025237647C2776362946 @default.
• W2025237647 hasConceptScore W2025237647C2776953305 @default.
• W2025237647 hasConceptScore W2025237647C2777495146 @default.
• W2025237647 hasConceptScore W2025237647C2778376644 @default.
• W2025237647 hasConceptScore W2025237647C2778782382 @default.
• W2025237647 hasConceptScore W2025237647C2779234561 @default.
• W2025237647 hasConceptScore W2025237647C49039625 @default.
• W2025237647 hasConceptScore W2025237647C54355233 @default.
• W2025237647 hasConceptScore W2025237647C71315377 @default.
• W2025237647 hasConceptScore W2025237647C71924100 @default.
• W2025237647 hasConceptScore W2025237647C79191276 @default.
• W2025237647 hasConceptScore W2025237647C86803240 @default.
• W2025237647 hasLocation W20252376471 @default.
• W2025237647 hasOpenAccess W2025237647 @default.
• W2025237647 hasPrimaryLocation W20252376471 @default.
• W2025237647 hasRelatedWork W186706167 @default.
• W2025237647 hasRelatedWork W2003454617 @default.
• W2025237647 hasRelatedWork W2004192393 @default.
• W2025237647 hasRelatedWork W2015720613 @default.
• W2025237647 hasRelatedWork W2015973191 @default.
• W2025237647 hasRelatedWork W2033600716 @default.
• W2025237647 hasRelatedWork W2078892098 @default.
• W2025237647 hasRelatedWork W2092941850 @default.
• W2025237647 hasRelatedWork W2100496553 @default.
• W2025237647 hasRelatedWork W2122096016 @default.
• W2025237647 hasRelatedWork W2127592877 @default.
• W2025237647 hasRelatedWork W2151772354 @default.
• W2025237647 hasRelatedWork W2315796377 @default.
• W2025237647 hasRelatedWork W2325762845 @default.
• W2025237647 hasRelatedWork W2361888663 @default.
• W2025237647 hasRelatedWork W2406306599 @default.
• W2025237647 hasRelatedWork W2417713570 @default.
• W2025237647 hasRelatedWork W2419434853 @default.

• next