Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025252912> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2025252912 endingPage "14" @default.
- W2025252912 startingPage "7" @default.
- W2025252912 abstract "The B-lymphocyte subset distribution was studied in 52 Graves' ophthalmopathy patients and 13 healthy controls. In a previous study an increase in total peripheral blood B cells was found in these patients when compared to controls (p < 0.001). In the present study the patients were classified according to their ocular symptoms, using the NOSPECS classification (five groups) or according to their thyroidal disease state (seven groups). The B cell subset distribution was studied for each of the subgroups. The B cell increase is polyclonal; both kappa and lambda bearing B cell numbers are increased. A significant increase of IgG-bearing B-cells is seen in seven out of ten patient subgroups. lncreased levels of IgM- and/ or IgD-bearing cells are found only in three out of ten patient subgroups and increased levels of IgA-bearing cells are found in two out of ten patient subgroups.In 42 of the 52 Graves' ophthalmopathy patients the serum immunoglobulin levels were studied and correlated with the B-cell abnormalities. Serum IgG levels were normal in all the patients. Increased levels of serum IgM were found in five subgroups and increased serum IgA levels in one subgroup.In conclusion, in Graves' ophthalmopathy patients mainly IgG kappa and IgG lambda bearing B-cells seem to proliferate in response to an as yet unknown signal. This B-cell proliferation occurs independently of the thyroidal or ocular symptoms. This polyclonal activation does not, however, appear to result in active secretion of immunoglobulins by the majority of the B-cells." @default.
- W2025252912 created "2016-06-24" @default.
- W2025252912 creator A5031690631 @default.
- W2025252912 creator A5041856608 @default.
- W2025252912 creator A5052631536 @default.
- W2025252912 creator A5066735272 @default.
- W2025252912 date "1986-01-01" @default.
- W2025252912 modified "2023-09-23" @default.
- W2025252912 title "B-lymphocyte subset distribution and serum immuno-globulin levels in Graves' ophthalmopathy patients" @default.
- W2025252912 cites W1994792951 @default.
- W2025252912 cites W1995962312 @default.
- W2025252912 cites W2006227557 @default.
- W2025252912 cites W2013806149 @default.
- W2025252912 cites W2016166868 @default.
- W2025252912 cites W2027080634 @default.
- W2025252912 cites W2032744734 @default.
- W2025252912 cites W2032949137 @default.
- W2025252912 cites W2044662797 @default.
- W2025252912 cites W2060220551 @default.
- W2025252912 cites W2063859091 @default.
- W2025252912 cites W2064581997 @default.
- W2025252912 cites W2076632506 @default.
- W2025252912 cites W2078190936 @default.
- W2025252912 cites W2118210213 @default.
- W2025252912 cites W2127890433 @default.
- W2025252912 cites W2145475153 @default.
- W2025252912 cites W2156317960 @default.
- W2025252912 doi "https://doi.org/10.3109/01676838609034229" @default.
- W2025252912 hasPublicationYear "1986" @default.
- W2025252912 type Work @default.
- W2025252912 sameAs 2025252912 @default.
- W2025252912 citedByCount "0" @default.
- W2025252912 crossrefType "journal-article" @default.
- W2025252912 hasAuthorship W2025252912A5031690631 @default.
- W2025252912 hasAuthorship W2025252912A5041856608 @default.
- W2025252912 hasAuthorship W2025252912A5052631536 @default.
- W2025252912 hasAuthorship W2025252912A5066735272 @default.
- W2025252912 hasConcept C126322002 @default.
- W2025252912 hasConcept C134018914 @default.
- W2025252912 hasConcept C159654299 @default.
- W2025252912 hasConcept C203014093 @default.
- W2025252912 hasConcept C2776090121 @default.
- W2025252912 hasConcept C2777761686 @default.
- W2025252912 hasConcept C2777785397 @default.
- W2025252912 hasConcept C2778453870 @default.
- W2025252912 hasConcept C48010095 @default.
- W2025252912 hasConcept C71924100 @default.
- W2025252912 hasConcept C8891405 @default.
- W2025252912 hasConcept C90924648 @default.
- W2025252912 hasConcept C956191 @default.
- W2025252912 hasConceptScore W2025252912C126322002 @default.
- W2025252912 hasConceptScore W2025252912C134018914 @default.
- W2025252912 hasConceptScore W2025252912C159654299 @default.
- W2025252912 hasConceptScore W2025252912C203014093 @default.
- W2025252912 hasConceptScore W2025252912C2776090121 @default.
- W2025252912 hasConceptScore W2025252912C2777761686 @default.
- W2025252912 hasConceptScore W2025252912C2777785397 @default.
- W2025252912 hasConceptScore W2025252912C2778453870 @default.
- W2025252912 hasConceptScore W2025252912C48010095 @default.
- W2025252912 hasConceptScore W2025252912C71924100 @default.
- W2025252912 hasConceptScore W2025252912C8891405 @default.
- W2025252912 hasConceptScore W2025252912C90924648 @default.
- W2025252912 hasConceptScore W2025252912C956191 @default.
- W2025252912 hasIssue "1" @default.
- W2025252912 hasLocation W20252529121 @default.
- W2025252912 hasOpenAccess W2025252912 @default.
- W2025252912 hasPrimaryLocation W20252529121 @default.
- W2025252912 hasRelatedWork W1984372436 @default.
- W2025252912 hasRelatedWork W2000239200 @default.
- W2025252912 hasRelatedWork W2015897818 @default.
- W2025252912 hasRelatedWork W2022583443 @default.
- W2025252912 hasRelatedWork W2047588347 @default.
- W2025252912 hasRelatedWork W2068999859 @default.
- W2025252912 hasRelatedWork W2077512515 @default.
- W2025252912 hasRelatedWork W2123776403 @default.
- W2025252912 hasRelatedWork W271486173 @default.
- W2025252912 hasRelatedWork W4230301897 @default.
- W2025252912 hasVolume "5" @default.
- W2025252912 isParatext "false" @default.
- W2025252912 isRetracted "false" @default.
- W2025252912 magId "2025252912" @default.
- W2025252912 workType "article" @default.