FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025254130> ?p ?o ?g. }

• W2025254130 endingPage "191" @default.
• W2025254130 startingPage "182" @default.
• W2025254130 abstract "The aim of this study is to determine if the mannose-induced protein (MIP-133) from Acanthamoeba castellanii trophozoites induces apoptosis of corneal epithelial cells through a cytosolic phospholipase A2α (cPLA2α)-mediated pathway. The efficacy of cPLA2α inhibitors to provide protection against Acanthamoeba keratitis was examined in vivo. Chinese hamster corneal epithelial (HCORN) cells were incubated with or without MIP-133. MIP-133 induces significant increase in cPLA2α and macrophage inflammatory protein-2 (MIP-2/CXCL2) levels from corneal cells. Moreover, cPLA2α inhibitors, MAFP (Methyl-arachidonyl fluorophosphonate) and AACOCF3 (Arachidonyl trifluoromethyl ketone), significantly reduce cPLA2α and CXCL2 from these cells (P < 0.05). Additionally, cPLA2α inhibitors significantly inhibit MIP-133-induced apoptosis in HCORN cells (P < 0.05). Subconjunctival injection of purified MIP-133 in Chinese hamster eyes induced cytopathic effects resulting in corneal ulceration. Animals infected with A. castellanii-laden contact lenses and treated with AACOCF3 and CAY10650, showed significantly less severe keratitis as compared with control animals. Collectively, the results indicate that cPLA2α is involved in MIP-133 induced apoptosis of corneal epithelial cells, polymorphonuclear neutrophil infiltration, and production of CXCL2. Moreover, cPLA2α inhibitors can be used as a therapeutic target in Acanthamoeba keratitis." @default.
• W2025254130 created "2016-06-24" @default.
• W2025254130 creator A5006095146 @default.
• W2025254130 creator A5020937290 @default.
• W2025254130 creator A5057382604 @default.
• W2025254130 date "2013-08-01" @default.
• W2025254130 modified "2023-10-16" @default.
• W2025254130 title "Role of phospholipase A2 (PLA2) inhibitors in attenuating apoptosis of the corneal epithelial cells and mitigation of Acanthamoeba keratitis" @default.
• W2025254130 cites W1594774706 @default.
• W2025254130 cites W1948142863 @default.
• W2025254130 cites W1971335269 @default.
• W2025254130 cites W1996082771 @default.
• W2025254130 cites W2016645421 @default.
• W2025254130 cites W2026597958 @default.
• W2025254130 cites W2032120870 @default.
• W2025254130 cites W2057761678 @default.
• W2025254130 cites W2060807189 @default.
• W2025254130 cites W2062137012 @default.
• W2025254130 cites W2062735984 @default.
• W2025254130 cites W2067683426 @default.
• W2025254130 cites W2081360580 @default.
• W2025254130 cites W2083681924 @default.
• W2025254130 cites W2085607766 @default.
• W2025254130 cites W2086998169 @default.
• W2025254130 cites W2096296061 @default.
• W2025254130 cites W2103258039 @default.
• W2025254130 cites W2126057936 @default.
• W2025254130 cites W2129093677 @default.
• W2025254130 cites W2131769377 @default.
• W2025254130 cites W2143326683 @default.
• W2025254130 cites W2148790418 @default.
• W2025254130 cites W2149357600 @default.
• W2025254130 cites W2158919286 @default.
• W2025254130 cites W2160944345 @default.
• W2025254130 cites W2165014087 @default.
• W2025254130 cites W2166614340 @default.
• W2025254130 cites W4232534952 @default.
• W2025254130 doi "https://doi.org/10.1016/j.exer.2013.05.021" @default.
• W2025254130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3742089" @default.
• W2025254130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23792108" @default.
• W2025254130 hasPublicationYear "2013" @default.
• W2025254130 type Work @default.
• W2025254130 sameAs 2025254130 @default.
• W2025254130 citedByCount "22" @default.
• W2025254130 countsByYear W20252541302014 @default.
• W2025254130 countsByYear W20252541302015 @default.
• W2025254130 countsByYear W20252541302016 @default.
• W2025254130 countsByYear W20252541302017 @default.
• W2025254130 countsByYear W20252541302019 @default.
• W2025254130 countsByYear W20252541302020 @default.
• W2025254130 countsByYear W20252541302021 @default.
• W2025254130 countsByYear W20252541302023 @default.
• W2025254130 crossrefType "journal-article" @default.
• W2025254130 hasAuthorship W2025254130A5006095146 @default.
• W2025254130 hasAuthorship W2025254130A5020937290 @default.
• W2025254130 hasAuthorship W2025254130A5057382604 @default.
• W2025254130 hasBestOaLocation W20252541302 @default.
• W2025254130 hasConcept C12823836 @default.
• W2025254130 hasConcept C13373296 @default.
• W2025254130 hasConcept C142724271 @default.
• W2025254130 hasConcept C179661763 @default.
• W2025254130 hasConcept C181199279 @default.
• W2025254130 hasConcept C190283241 @default.
• W2025254130 hasConcept C203014093 @default.
• W2025254130 hasConcept C2776079991 @default.
• W2025254130 hasConcept C2776551241 @default.
• W2025254130 hasConcept C2776914184 @default.
• W2025254130 hasConcept C2778560704 @default.
• W2025254130 hasConcept C2778868110 @default.
• W2025254130 hasConcept C2779257441 @default.
• W2025254130 hasConcept C2780576314 @default.
• W2025254130 hasConcept C529295009 @default.
• W2025254130 hasConcept C54355233 @default.
• W2025254130 hasConcept C55493867 @default.
• W2025254130 hasConcept C71924100 @default.
• W2025254130 hasConcept C86803240 @default.
• W2025254130 hasConcept C89423630 @default.
• W2025254130 hasConcept C96525457 @default.
• W2025254130 hasConceptScore W2025254130C12823836 @default.
• W2025254130 hasConceptScore W2025254130C13373296 @default.
• W2025254130 hasConceptScore W2025254130C142724271 @default.
• W2025254130 hasConceptScore W2025254130C179661763 @default.
• W2025254130 hasConceptScore W2025254130C181199279 @default.
• W2025254130 hasConceptScore W2025254130C190283241 @default.
• W2025254130 hasConceptScore W2025254130C203014093 @default.
• W2025254130 hasConceptScore W2025254130C2776079991 @default.
• W2025254130 hasConceptScore W2025254130C2776551241 @default.
• W2025254130 hasConceptScore W2025254130C2776914184 @default.
• W2025254130 hasConceptScore W2025254130C2778560704 @default.
• W2025254130 hasConceptScore W2025254130C2778868110 @default.
• W2025254130 hasConceptScore W2025254130C2779257441 @default.
• W2025254130 hasConceptScore W2025254130C2780576314 @default.
• W2025254130 hasConceptScore W2025254130C529295009 @default.
• W2025254130 hasConceptScore W2025254130C54355233 @default.
• W2025254130 hasConceptScore W2025254130C55493867 @default.
• W2025254130 hasConceptScore W2025254130C71924100 @default.
• W2025254130 hasConceptScore W2025254130C86803240 @default.
• W2025254130 hasConceptScore W2025254130C89423630 @default.

• next