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• W2025256411 abstract "Purpose: To evaluate the effects of listening to favorite music on the endothelial function, assess through changes of circulating blood markers of endothelial function: the stable end product of Nitric Oxide (NOx), Dimethylarginine (ADMA), Symmetric Dimethylarginine (SDMA) and Xanthine Oxidase (XO), in patients (pts) with Coronary Artery Disease (CAD).Methods: 74pts with stable CAD were studied. At baseline and 3 weeks later, in all pts values of NOx, ADMA, SDMA and XO were evaluated and exercise test was performed. After the initial study, pts were randomized to trained (T,n=33), music and trained (MT, n=31) and music (M,n=10) group. Patients in T and MT group underwent a supervised 3 weeks aerobic exercise training at residential center. Additional to exercise training, patients in MT group were listening to their favorite music, for half an hour, every day. Patients in M group received usual community care and were listening to their favorite music for half an hour every day.Results: After 3 weeks NOx increased in T group (from 33.0±13.0 to 42.8±11.0 μmol/l, P< 0.005), MT group (from 34.5±7.1 to 49.6±12.6 μmol/l, P<0.0005) and M group (from 32.8±6.5 to 36.5±7.0 μmol/l, ns). However increase in NOx was higher in MT than in T and M group (P=0.0246 and P<0.005), and in T than in M group (P<0.05). Value of ADMA as well of SDMA decreased in all three groups (ns) after 3 weeks, and this reduction was the most pronounced in MT group. Compared to the baseline, value of XO at the end of the study was significantly lower in T, MT and M group (P<0.0005 for all of them). However at the end of the study value of XO was significantly lower in MT than in T and M group (P<0.005 and P<0.0005) and in T than in M group (P<0.001). After 3 weeks exercise capacity significantly increased in T, MT and M group (P<0.001, P<0.001 and P<0.025), and increase in exercise capacity was higher in MT than in T and M group (39% vs 29% and 19%).Conclusion: In pts with CAD listening to favorite music alone as well as in addition to regular exercise training, improves endothelial function. Combination of music and exercise training leads to more favorable improvement in endothelial function, expressed through higher increased of NOx, decreased of ADMA, SDMA and XO than exercise training alone. This improvement in endothelial function is associated with significant improvement in exercise capacity." @default.
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• W2025256411 date "2013-08-02" @default.
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• W2025256411 title "Effects of music therapy on endothelial function in patients with coronary artery disease participating in rehabilitation" @default.
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