Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025271498> ?p ?o ?g. }
- W2025271498 endingPage "136" @default.
- W2025271498 startingPage "133" @default.
- W2025271498 abstract "Disruption of circadian rhythms may be involved in the pathophysiology of psychiatric disorders, including drug addiction. Recently, we detected the significant association between prokineticin 2 receptor gene (PROKR2) and Japanese methamphetamine dependence patients. Also, prokineticin 2 (PK2) gene deficient mice showed reduced physiological and behavioral parameters, including circadian locomotor activity, circulating glucocorticoid, glucose levels and the expression of peripheral clock genes compared with WT mice. These evidences indicate that PK2 gene (PROK2) is a good candidate gene for the pathogenesis of methamphetamine dependence. To evaluate the association between PROK2 and methamphetamine dependence, we conducted a case-control study of Japanese samples (215 methamphetamine dependence and 232 controls) with four tagging SNPs selected by HapMap database. The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). We did not detect an association between PROK2 and Japanese methamphetamine dependence patients in allele/genotype-wise analysis, or the haplotype analysis. Our findings suggest that PROK2 does not play a major role in the pathophysiology of methamphetamine dependence in the Japanese population." @default.
- W2025271498 created "2016-06-24" @default.
- W2025271498 creator A5000167582 @default.
- W2025271498 creator A5009599515 @default.
- W2025271498 creator A5015137967 @default.
- W2025271498 creator A5018647067 @default.
- W2025271498 creator A5025234337 @default.
- W2025271498 creator A5026728831 @default.
- W2025271498 creator A5033793584 @default.
- W2025271498 creator A5034723746 @default.
- W2025271498 creator A5045107955 @default.
- W2025271498 creator A5047193478 @default.
- W2025271498 creator A5057181114 @default.
- W2025271498 creator A5060189993 @default.
- W2025271498 creator A5063361747 @default.
- W2025271498 creator A5081800572 @default.
- W2025271498 creator A5085675155 @default.
- W2025271498 creator A5090481309 @default.
- W2025271498 date "2011-03-01" @default.
- W2025271498 modified "2023-10-18" @default.
- W2025271498 title "Lack of Association Between Prokineticin 2 Gene and Japanese Methamphetamine Dependence" @default.
- W2025271498 doi "https://doi.org/10.2174/157015911795016994" @default.
- W2025271498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3137168" @default.
- W2025271498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21886578" @default.
- W2025271498 hasPublicationYear "2011" @default.
- W2025271498 type Work @default.
- W2025271498 sameAs 2025271498 @default.
- W2025271498 citedByCount "5" @default.
- W2025271498 countsByYear W20252714982012 @default.
- W2025271498 countsByYear W20252714982015 @default.
- W2025271498 countsByYear W20252714982023 @default.
- W2025271498 crossrefType "journal-article" @default.
- W2025271498 hasAuthorship W2025271498A5000167582 @default.
- W2025271498 hasAuthorship W2025271498A5009599515 @default.
- W2025271498 hasAuthorship W2025271498A5015137967 @default.
- W2025271498 hasAuthorship W2025271498A5018647067 @default.
- W2025271498 hasAuthorship W2025271498A5025234337 @default.
- W2025271498 hasAuthorship W2025271498A5026728831 @default.
- W2025271498 hasAuthorship W2025271498A5033793584 @default.
- W2025271498 hasAuthorship W2025271498A5034723746 @default.
- W2025271498 hasAuthorship W2025271498A5045107955 @default.
- W2025271498 hasAuthorship W2025271498A5047193478 @default.
- W2025271498 hasAuthorship W2025271498A5057181114 @default.
- W2025271498 hasAuthorship W2025271498A5060189993 @default.
- W2025271498 hasAuthorship W2025271498A5063361747 @default.
- W2025271498 hasAuthorship W2025271498A5081800572 @default.
- W2025271498 hasAuthorship W2025271498A5085675155 @default.
- W2025271498 hasAuthorship W2025271498A5090481309 @default.
- W2025271498 hasBestOaLocation W20252714982 @default.
- W2025271498 hasConcept C104317684 @default.
- W2025271498 hasConcept C118552586 @default.
- W2025271498 hasConcept C126322002 @default.
- W2025271498 hasConcept C135763542 @default.
- W2025271498 hasConcept C153209595 @default.
- W2025271498 hasConcept C15744967 @default.
- W2025271498 hasConcept C177580304 @default.
- W2025271498 hasConcept C180754005 @default.
- W2025271498 hasConcept C186413461 @default.
- W2025271498 hasConcept C197754878 @default.
- W2025271498 hasConcept C2780376393 @default.
- W2025271498 hasConcept C48856860 @default.
- W2025271498 hasConcept C54355233 @default.
- W2025271498 hasConcept C71924100 @default.
- W2025271498 hasConcept C86803240 @default.
- W2025271498 hasConcept C98274493 @default.
- W2025271498 hasConceptScore W2025271498C104317684 @default.
- W2025271498 hasConceptScore W2025271498C118552586 @default.
- W2025271498 hasConceptScore W2025271498C126322002 @default.
- W2025271498 hasConceptScore W2025271498C135763542 @default.
- W2025271498 hasConceptScore W2025271498C153209595 @default.
- W2025271498 hasConceptScore W2025271498C15744967 @default.
- W2025271498 hasConceptScore W2025271498C177580304 @default.
- W2025271498 hasConceptScore W2025271498C180754005 @default.
- W2025271498 hasConceptScore W2025271498C186413461 @default.
- W2025271498 hasConceptScore W2025271498C197754878 @default.
- W2025271498 hasConceptScore W2025271498C2780376393 @default.
- W2025271498 hasConceptScore W2025271498C48856860 @default.
- W2025271498 hasConceptScore W2025271498C54355233 @default.
- W2025271498 hasConceptScore W2025271498C71924100 @default.
- W2025271498 hasConceptScore W2025271498C86803240 @default.
- W2025271498 hasConceptScore W2025271498C98274493 @default.
- W2025271498 hasIssue "1" @default.
- W2025271498 hasLocation W20252714981 @default.
- W2025271498 hasLocation W20252714982 @default.
- W2025271498 hasLocation W20252714983 @default.
- W2025271498 hasLocation W20252714984 @default.
- W2025271498 hasOpenAccess W2025271498 @default.
- W2025271498 hasPrimaryLocation W20252714981 @default.
- W2025271498 hasRelatedWork W165247578 @default.
- W2025271498 hasRelatedWork W1969997927 @default.
- W2025271498 hasRelatedWork W1989752273 @default.
- W2025271498 hasRelatedWork W2032474379 @default.
- W2025271498 hasRelatedWork W2036715394 @default.
- W2025271498 hasRelatedWork W2060181803 @default.
- W2025271498 hasRelatedWork W2078156505 @default.
- W2025271498 hasRelatedWork W2091143313 @default.
- W2025271498 hasRelatedWork W2328231353 @default.
- W2025271498 hasRelatedWork W2468405568 @default.