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• W2025272839 abstract "<h3>Context</h3> Neural substrates for low cognitive performance and depression, common long-term central nervous system–related changes in patients with type 1 diabetes mellitus, have not yet been studied. <h3>Objective</h3> To investigate whether prefrontal glutamate levels are higher in patients with type 1 diabetes and whether an elevation is related to lower cognitive performance and depression. <h3>Design</h3> Cross-sectional study. <h3>Setting</h3> General clinical research center. <h3>Participants</h3> One hundred twenty-three patients with adult type 1 diabetes with varying degrees of lifetime glycemic control and 38 healthy participants. <h3>Main Outcome Measures</h3> With the use of proton magnetic resonance spectroscopy, prefrontal glutamate–glutamine–γ-aminobutyric acid (Glx) levels were compared between patients and control subjects. Relationships between prefrontal Glx levels and cognitive function and between Glx levels and mild depressive symptoms were assessed in patients with type 1 diabetes. <h3>Results</h3> Prefrontal Glx concentrations were 9.0% (0.742 mmol/L;<i>P</i> = .005) higher in adult patients with type 1 diabetes than in healthy control subjects. There were positive linear trends for the effects of lifetime glycemic control on prefrontal Glx levels (<i>P</i>for trend = .002). Cognitive performances in memory, executive function, and psychomotor speed were lower in patients (<i>P</i> = .003, .01, and <.001, respectively) than in control subjects. Higher prefrontal Glx concentrations in patients were associated with lower performance in assessment of global cognitive function (0.11 change in<i>z</i>score per 1-mmol/L increase in Glx) as well as with mild depression. <h3>Conclusions</h3> The high prefrontal glutamate levels documented in this study may play an important role in the genesis of the low cognitive performance and mild depression frequently observed in patients with type 1 diabetes. Therapeutic options that alter glutamatergic neurotransmission may be of benefit in treating central nervous system–related changes in patients with adult type 1 diabetes." @default.
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• W2025272839 date "2009-08-01" @default.
• W2025272839 modified "2023-10-16" @default.
• W2025272839 title "Altered Prefrontal Glutamate–Glutamine–γ-Aminobutyric Acid Levels and Relation to Low Cognitive Performance and Depressive Symptoms in Type 1 Diabetes Mellitus" @default.
• W2025272839 cites W1514838725 @default.
• W2025272839 cites W1542202136 @default.
• W2025272839 cites W1730237872 @default.
• W2025272839 cites W1914703486 @default.
• W2025272839 cites W1964634661 @default.
• W2025272839 cites W1971082120 @default.
• W2025272839 cites W1972153696 @default.
• W2025272839 cites W1976313368 @default.
• W2025272839 cites W1983922793 @default.
• W2025272839 cites W1984688870 @default.
• W2025272839 cites W1986577113 @default.
• W2025272839 cites W1990672257 @default.
• W2025272839 cites W1996653842 @default.
• W2025272839 cites W2003432290 @default.
• W2025272839 cites W2006641643 @default.
• W2025272839 cites W2008351358 @default.
• W2025272839 cites W2011592290 @default.
• W2025272839 cites W2015536104 @default.
• W2025272839 cites W2023630108 @default.
• W2025272839 cites W2023798788 @default.
• W2025272839 cites W2023866167 @default.
• W2025272839 cites W2024016510 @default.
• W2025272839 cites W2026283383 @default.
• W2025272839 cites W2033352712 @default.
• W2025272839 cites W2037963550 @default.
• W2025272839 cites W2039072127 @default.
• W2025272839 cites W2045614704 @default.
• W2025272839 cites W2049560728 @default.
• W2025272839 cites W2055740037 @default.
• W2025272839 cites W2063578228 @default.
• W2025272839 cites W2064330815 @default.
• W2025272839 cites W2071811706 @default.
• W2025272839 cites W2072652145 @default.
• W2025272839 cites W2072972701 @default.
• W2025272839 cites W2074289124 @default.
• W2025272839 cites W2074907255 @default.
• W2025272839 cites W2074925149 @default.
• W2025272839 cites W2076681561 @default.
• W2025272839 cites W2079598505 @default.
• W2025272839 cites W2083144456 @default.
• W2025272839 cites W2084722875 @default.
• W2025272839 cites W2087916050 @default.
• W2025272839 cites W2088577867 @default.
• W2025272839 cites W2092356280 @default.
• W2025272839 cites W2096638086 @default.
• W2025272839 cites W2098735230 @default.
• W2025272839 cites W2109334244 @default.
• W2025272839 cites W2112256576 @default.
• W2025272839 cites W2114163624 @default.
• W2025272839 cites W2114613490 @default.
• W2025272839 cites W2117217305 @default.
• W2025272839 cites W2119615091 @default.
• W2025272839 cites W2123808061 @default.
• W2025272839 cites W2127077664 @default.
• W2025272839 cites W2136022845 @default.
• W2025272839 cites W2138321181 @default.
• W2025272839 cites W2146172555 @default.
• W2025272839 cites W2151688741 @default.
• W2025272839 cites W2158388157 @default.
• W2025272839 cites W2158402798 @default.
• W2025272839 cites W2163813283 @default.
• W2025272839 cites W2164398286 @default.
• W2025272839 cites W2165563030 @default.
• W2025272839 cites W2167415409 @default.
• W2025272839 cites W2171242179 @default.
• W2025272839 cites W2315115348 @default.
• W2025272839 cites W2735928575 @default.
• W2025272839 cites W2705014566 @default.
• W2025272839 doi "https://doi.org/10.1001/archgenpsychiatry.2009.86" @default.
• W2025272839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19652127" @default.
• W2025272839 hasPublicationYear "2009" @default.
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